A 40 years old lady, house wife, lives in Phnom Penh, comes to Psychiatric OPD with her complaint of difficulty in breathing, cold extremities, difficulty falling asleep and look a bit pale. Her symptoms happened for more than 2 years. Her BP: 125/80mnhg, Pulse: 98/mn, T: 36.5 oC. If the patient answer with the therapist question with palpitation, sweating, trembling, psychological distress most of every day and could not stay home alone. Which is the main following diagnosis could be made?