1) Aspirin acts on what of the following enzymes?

2) Interaction of Tetracycline with Aluminum is done through what process?

3) What is the effect of NSAID + Warfarin?

4) Interaction of Digoxin combined with Quinidine is done through what process?

5) What properties of a drug is to be said inverse agonist?

6) What cause the adverse effect of water-soluble drug in elderly person?

7) Define Gene

8) When partial agonist drug is given with full agonist drug, what is the dynamic interaction as a result?

9) Aldosterone achieves its effect through what mechanism?

10) How many haft lives of drug we administrate to get its plasma concentration at steady state?

11) What is the formula for bioavailability of drug? AUC area under curve

12) What polymorphism gene that relate to affinity of warfarin?

13) What properties of a drug is to be said full agonist?

14) Define inverse agonist

15) What is the haft life of a drug with constant elimination Ke 1/10?

16) Loop diuretics achieves its effect through binding what type of the following transporters?

17) Effect of aspirin acts through what mechanism?

18) Which drug is excreted with zero order kinetic?

19) What is the effect of AVP on V2 receptor?

20) What Enzyme deficiency due to gene mutation → interaction thiopurine with allopurinol?

21) What pathway of administration of drug result in bioavailability 100%?

22) Poor acetylation may alter metabolism of what drugs?

23) What is the result of polymorphism for an individual to response to a drug?

24) What metabolic pathway of drug is preferred to the elderly person?

25) What Enzyme detoxify 5FU?

26) Exemestane act on what enzyme?

27) What HLA gene that related to susceptibility of abacavir?

28) What is the property of a drug with small volume distribution?

29) Explain what mitochondria DNA mutation give rise to gentamycin ototoxicity?

30) What Enzyme deficiency related to gene mutation → hemolysis?

31) What is the common substitution of nucleotide in polymorphism?

32) What is the mechanism of action of morphine?

33) Formulate half-life T1/2 related to rate of elimination Ke?

34) Poor acetylation may alter metabolism of what drugs?

35) Poor metabolism to convert codeine to morphine require how dose of codeine?

36) Finasteride act on what enzyme?

37) What Enzyme deficiency related to gene mutation → bone toxicity by thiopurines?

38) What is the meaning of EC50?

39) What polymorphism gene that relate to warfarin metabolism?

40) How many haft lives of drug the kidney should clear it totally from the body?

41) What is the formula of plasma centration of drug at any time (CT) during elimination? C0: initial concentration; Ke constant of elimination; T: time

42) Which drug is excreted with zero order kinetic?

43) Define mutation

44) What is the management to interaction of interaction cimetidine – warfarin?

45) Theophylline acts trough what mechanism?

46) Triamterene acts on what of the following transporters?

47) Owing to Kd = dissociation constant; Ro = Total receptor. Formulate law mass action indicating the interaction between Drug – Receptor (D – R)

48) Relate elimination constant (Ke) to clearance (CL) and distribution volume (Vd) of drug?

49) Aspirin is a weak acid with pK3. What pH in the stomach Aspirin would be highly absorbed?

50) Omeprazole achieves its effect through binding what type of the following transporters?

51) Define polymorphism

52) What is single nucleotide polymorphism?

53) Calcium channel blocker acts through what mechanism?

54) What cause the adverse effect of fat-soluble drug in elderly person?

55) Sildenafil acts trough what mechanism?

56) What is the distribution volume of a drug given 500mg iv with its plasma concentration 25mg/L at steady state?

57) What HLA gene that related to agranulocytosis with carbamazepine?

58) Amlodipine acts on what of the following transporters?

59) Amphetamine is weak base with pK3. What pH in the intestine, it would be highly absorbed?

60) THIAZIDES acts on what of the following transporters?

61) What second messenger involved in mechanism of action of morphine?

62) What cytochrome involved in interaction of verapamil and rifampicin?

63) What is the effect of AVP on V1 receptor?

64) What is the signification of dissociation constant Kd?

65) What is the loading dose of a drug with volume distribution 20L and its plasma concentration required at steady state is 25 mg/L?

66) Which of the following metabolisms is used in biotransformation (phase 1) in the liver?

67) Digoxin acts on what of the following transporters?

68) Furosemide acts on what of the following transporters?

69) What combination should be avoided in a patient with ischemic heart disease?

70) What quality of drug is to be said high affinity to its target?

71) What is the property of a drug with full agonist but low potency?

72) What HLA gene that related to Stevens Johnson syndrome with carbamazepine?

73) What is the property of a drug with full agonist and high potency?

74) What cytochrome involved in interaction of warfarin and phenobarbital?

75) What cytochrome involved in metabolism of imipramine?

76) Interaction of probenecid administrated with cephalosporin is done through what process?

77) Poor acetylation may alter metabolism of what drugs?

78) What polymorphism gene that relate to tamoxifen metabolism?

79) What is the management to avoid interaction of rifampicin with warfarin?

80) What cytochrome involved in interaction of erythromycin and phenobarbital?

81) What are the components of base sequence?

82) Amiloride acts on what of the following transporters?

83) Amphetamine is weak base with pK3. What pH in the intestine, it would be absorbed 50%?

84) Omeprazole acts on what of the following transporters?

85) Aspirin is a weak acid with pK3. What pH in the stomach Aspirin would be absorbed 50%?

86) Amlodipine (CCB) achieves its effect through binding what type of the following transporters?

87) Which of the following formula is correct concerning affinity of drug (Kd = dissociation constant)?

88) Which of the following metabolisms is used to conjugate (phase 2) a metabolite in the liver?

89) What is the constant of dissociation of a drug Kd from its target?

90) Interaction of Warfarin combined with cimetidine is done through what process?

91) Physostigmine act on what enzyme?

92) What is the property of a drug with partial agonist but high potency?

93) What is the property of a drug with large volume distribution?

94) What is the property of a drug with full agonist and low potency?

95) What properties of a drug is to be said antagonist?

96) Give the equation for maintenance dose?

97) Digoxin achieves its effect through binding what type of the following transporters?