1) Theophylline acts trough what mechanism?

2) What is the property of a drug with partial agonist but high potency?

3) Define polymorphism

4) Aspirin is a weak acid with pK3. What pH in the stomach Aspirin would be absorbed 50%?

5) What cytochrome involved in metabolism of imipramine?

6) What is the meaning of EC50?

7) Furosemide acts on what of the following transporters?

8) What polymorphism gene that relate to affinity of warfarin?

9) Relate elimination constant (Ke) to clearance (CL) and distribution volume (Vd) of drug?

10) Owing to Kd = dissociation constant; Ro = Total receptor. Formulate law mass action indicating the interaction between Drug – Receptor (D – R)

11) Poor metabolism to convert codeine to morphine require how dose of codeine?

12) Exemestane act on what enzyme?

13) Amphetamine is weak base with pK3. What pH in the intestine, it would be absorbed 50%?

14) Interaction of Tetracycline with Aluminum is done through what process?

15) Amlodipine (CCB) achieves its effect through binding what type of the following transporters?

16) What is the distribution volume of a drug given 500mg iv with its plasma concentration 25mg/L at steady state?

17) What Enzyme deficiency due to gene mutation → interaction thiopurine with allopurinol?

18) What is the property of a drug with large volume distribution?

19) What is the result of polymorphism for an individual to response to a drug?

20) What HLA gene that related to Stevens Johnson syndrome with carbamazepine?

21) What Enzyme detoxify 5FU?

22) What cause the adverse effect of fat-soluble drug in elderly person?

23) Interaction of Digoxin combined with Quinidine is done through what process?

24) Which of the following metabolisms is used in biotransformation (phase 1) in the liver?

25) Digoxin achieves its effect through binding what type of the following transporters?

26) What polymorphism gene that relate to tamoxifen metabolism?

27) What is the property of a drug with full agonist but low potency?

28) What is the property of a drug with full agonist and high potency?

29) What HLA gene that related to susceptibility of abacavir?

30) When partial agonist drug is given with full agonist drug, what is the dynamic interaction as a result?

31) What is single nucleotide polymorphism?

32) What is the haft life of a drug with constant elimination Ke 1/10?

33) Which of the following formula is correct concerning affinity of drug (Kd = dissociation constant)?

34) Sildenafil acts trough what mechanism?

35) What cause the adverse effect of water-soluble drug in elderly person?

36) What is the management to interaction of interaction cimetidine – warfarin?

37) What is the signification of dissociation constant Kd?

38) What HLA gene that related to agranulocytosis with carbamazepine?

39) Define Gene

40) Calcium channel blocker acts through what mechanism?

41) How many haft lives of drug the kidney should clear it totally from the body?

42) Effect of aspirin acts through what mechanism?

43) Amiloride acts on what of the following transporters?

44) Amlodipine acts on what of the following transporters?

45) THIAZIDES acts on what of the following transporters?

46) What is the effect of AVP on V1 receptor?

47) Omeprazole acts on what of the following transporters?

48) Which drug is excreted with zero order kinetic?

49) What combination should be avoided in a patient with ischemic heart disease?

50) Define mutation

51) What is the property of a drug with small volume distribution?

52) Which of the following metabolisms is used to conjugate (phase 2) a metabolite in the liver?

53) What Enzyme deficiency related to gene mutation → hemolysis?

54) Aspirin is a weak acid with pK3. What pH in the stomach Aspirin would be highly absorbed?

55) What properties of a drug is to be said antagonist?

56) What is the mechanism of action of morphine?

57) What polymorphism gene that relate to warfarin metabolism?

58) Which drug is excreted with zero order kinetic?

59) Digoxin acts on what of the following transporters?

60) What is the formula for bioavailability of drug? AUC area under curve

61) Formulate half-life T1/2 related to rate of elimination Ke?

62) Finasteride act on what enzyme?

63) Define inverse agonist

64) What is the management to avoid interaction of rifampicin with warfarin?

65) Aldosterone achieves its effect through what mechanism?

66) Omeprazole achieves its effect through binding what type of the following transporters?

67) Amphetamine is weak base with pK3. What pH in the intestine, it would be highly absorbed?

68) What properties of a drug is to be said full agonist?

69) What Enzyme deficiency related to gene mutation → bone toxicity by thiopurines?

70) What cytochrome involved in interaction of warfarin and phenobarbital?

71) What cytochrome involved in interaction of verapamil and rifampicin?

72) Interaction of Warfarin combined with cimetidine is done through what process?

73) What properties of a drug is to be said inverse agonist?

74) What cytochrome involved in interaction of erythromycin and phenobarbital?

75) Physostigmine act on what enzyme?

76) What is the formula of plasma centration of drug at any time (CT) during elimination? C0: initial concentration; Ke constant of elimination; T: time

77) What is the loading dose of a drug with volume distribution 20L and its plasma concentration required at steady state is 25 mg/L?

78) Poor acetylation may alter metabolism of what drugs?

79) Poor acetylation may alter metabolism of what drugs?

80) What is the property of a drug with full agonist and low potency?

81) Triamterene acts on what of the following transporters?

82) Poor acetylation may alter metabolism of what drugs?

83) What is the effect of AVP on V2 receptor?

84) What is the common substitution of nucleotide in polymorphism?

85) What second messenger involved in mechanism of action of morphine?

86) Loop diuretics achieves its effect through binding what type of the following transporters?

87) What is the effect of NSAID + Warfarin?

88) What is the constant of dissociation of a drug Kd from its target?

89) What are the components of base sequence?

90) Aspirin acts on what of the following enzymes?

91) Explain what mitochondria DNA mutation give rise to gentamycin ototoxicity?

92) Interaction of probenecid administrated with cephalosporin is done through what process?

93) What pathway of administration of drug result in bioavailability 100%?

94) What metabolic pathway of drug is preferred to the elderly person?

95) How many haft lives of drug we administrate to get its plasma concentration at steady state?

96) What quality of drug is to be said high affinity to its target?

97) Give the equation for maintenance dose?