1) What cytochrome involved in interaction of erythromycin and phenobarbital?

2) What is the management to interaction of interaction cimetidine – warfarin?

3) Digoxin acts on what of the following transporters?

4) What is the mechanism of action of morphine?

5) Which drug is excreted with zero order kinetic?

6) Aspirin is a weak acid with pK3. What pH in the stomach Aspirin would be highly absorbed?

7) Calcium channel blocker acts through what mechanism?

8) Which of the following formula is correct concerning affinity of drug (Kd = dissociation constant)?

9) What is the loading dose of a drug with volume distribution 20L and its plasma concentration required at steady state is 25 mg/L?

10) Define inverse agonist

11) Furosemide acts on what of the following transporters?

12) What HLA gene that related to agranulocytosis with carbamazepine?

13) What is the result of polymorphism for an individual to response to a drug?

14) What second messenger involved in mechanism of action of morphine?

15) What cytochrome involved in interaction of verapamil and rifampicin?

16) What HLA gene that related to Stevens Johnson syndrome with carbamazepine?

17) What is the property of a drug with full agonist and high potency?

18) Give the equation for maintenance dose?

19) Exemestane act on what enzyme?

20) What is the effect of AVP on V2 receptor?

21) Finasteride act on what enzyme?

22) Interaction of Warfarin combined with cimetidine is done through what process?

23) What properties of a drug is to be said full agonist?

24) What is the signification of dissociation constant Kd?

25) What is the management to avoid interaction of rifampicin with warfarin?

26) What is the property of a drug with small volume distribution?

27) Digoxin achieves its effect through binding what type of the following transporters?

28) When partial agonist drug is given with full agonist drug, what is the dynamic interaction as a result?

29) What is the property of a drug with full agonist but low potency?

30) Poor acetylation may alter metabolism of what drugs?

31) Triamterene acts on what of the following transporters?

32) What properties of a drug is to be said antagonist?

33) Interaction of Digoxin combined with Quinidine is done through what process?

34) What is the formula of plasma centration of drug at any time (CT) during elimination? C0: initial concentration; Ke constant of elimination; T: time

35) How many haft lives of drug the kidney should clear it totally from the body?

36) What is the common substitution of nucleotide in polymorphism?

37) What is the haft life of a drug with constant elimination Ke 1/10?

38) Interaction of probenecid administrated with cephalosporin is done through what process?

39) What cytochrome involved in interaction of warfarin and phenobarbital?

40) Effect of aspirin acts through what mechanism?

41) What is the effect of NSAID + Warfarin?

42) What quality of drug is to be said high affinity to its target?

43) Aspirin is a weak acid with pK3. What pH in the stomach Aspirin would be absorbed 50%?

44) What cause the adverse effect of water-soluble drug in elderly person?

45) Amphetamine is weak base with pK3. What pH in the intestine, it would be highly absorbed?

46) Theophylline acts trough what mechanism?

47) Amiloride acts on what of the following transporters?

48) Physostigmine act on what enzyme?

49) Aspirin acts on what of the following enzymes?

50) What Enzyme deficiency due to gene mutation → interaction thiopurine with allopurinol?

51) What HLA gene that related to susceptibility of abacavir?

52) What properties of a drug is to be said inverse agonist?

53) What is the property of a drug with partial agonist but high potency?

54) What Enzyme detoxify 5FU?

55) Interaction of Tetracycline with Aluminum is done through what process?

56) Which of the following metabolisms is used in biotransformation (phase 1) in the liver?

57) Define polymorphism

58) What pathway of administration of drug result in bioavailability 100%?

59) What combination should be avoided in a patient with ischemic heart disease?

60) Define mutation

61) What is the formula for bioavailability of drug? AUC area under curve

62) Amlodipine (CCB) achieves its effect through binding what type of the following transporters?

63) Omeprazole achieves its effect through binding what type of the following transporters?

64) Which of the following metabolisms is used to conjugate (phase 2) a metabolite in the liver?

65) Loop diuretics achieves its effect through binding what type of the following transporters?

66) Explain what mitochondria DNA mutation give rise to gentamycin ototoxicity?

67) How many haft lives of drug we administrate to get its plasma concentration at steady state?

68) What is the meaning of EC50?

69) What Enzyme deficiency related to gene mutation → hemolysis?

70) Aldosterone achieves its effect through what mechanism?

71) What cause the adverse effect of fat-soluble drug in elderly person?

72) Which drug is excreted with zero order kinetic?

73) What is the distribution volume of a drug given 500mg iv with its plasma concentration 25mg/L at steady state?

74) What metabolic pathway of drug is preferred to the elderly person?

75) What is the property of a drug with large volume distribution?

76) What cytochrome involved in metabolism of imipramine?

77) What polymorphism gene that relate to tamoxifen metabolism?

78) What is single nucleotide polymorphism?

79) Amlodipine acts on what of the following transporters?

80) What polymorphism gene that relate to affinity of warfarin?

81) THIAZIDES acts on what of the following transporters?

82) Sildenafil acts trough what mechanism?

83) Poor acetylation may alter metabolism of what drugs?

84) Relate elimination constant (Ke) to clearance (CL) and distribution volume (Vd) of drug?

85) Owing to Kd = dissociation constant; Ro = Total receptor. Formulate law mass action indicating the interaction between Drug – Receptor (D – R)

86) Poor acetylation may alter metabolism of what drugs?

87) Define Gene

88) What is the property of a drug with full agonist and low potency?

89) Formulate half-life T1/2 related to rate of elimination Ke?

90) What is the effect of AVP on V1 receptor?

91) What polymorphism gene that relate to warfarin metabolism?

92) What Enzyme deficiency related to gene mutation → bone toxicity by thiopurines?

93) Omeprazole acts on what of the following transporters?

94) What are the components of base sequence?

95) Amphetamine is weak base with pK3. What pH in the intestine, it would be absorbed 50%?

96) Poor metabolism to convert codeine to morphine require how dose of codeine?

97) What is the constant of dissociation of a drug Kd from its target?