Pharmacologie Preparation (Pr. BC Youttiroung)

/65

1 / 65

1) What is the most common adverse reactions of PZA ?

a. . Hyperuricemia may provoke acute gouty arthritis.

b. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. . Ototoxic and Nephrotoxic.

d. . Harmless orange color to urine, sweats, tears, and contact lenses.

e. . Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

2 / 65

2) Dose of rifampicin recommended in multibacillary leprosy in adult is 600 mg

a. Once in a week

b. Twice monthly

c. Once in a month

d. Twice weekly

e. Once daily

3 / 65

3) What is the Mechanism of action EMB against TB?

a. . Inhibits RNA synthesis.

b. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

d. . Inhibits synthesis of mycolic acids.

e. . Inhibits mycobacterial arabinosyltransferases.

4 / 65

4) What is the Mechanism of Action of Isoniazid against M tuberculosis? Choose one best answer.

a. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

b. Inhibits mycobacterial arabinosyltransferases.

c. Inhibits RNA synthesis.

d. Inhibits synthesis of mycolic acids.

e. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

5 / 65

5) A patient taking Anti-leprosy treatment, then he come back with his lawyer because his skin is dusty, his tongue and lips are blue…and he threatens to sue….He has headache and also tired because of you. His SaO 2 is low. Which one of the following drugs can cause this adverse reaction?

a. Clofazimine

b. Dapsone

c. Steroid

d. Rifampcin

e. Thalidomide

6 / 65

6) Which statement is the adverse reaction of Clofazimine? Choose one best answer.

a. Hemolysis, particularly if they have G6PD deficiency.

b. Methemoglobinemia is common, but usually is not a problem clinically.

c. Erythema nodosumleprosum often develops.

d. Gastrointestinal intolerance, fever, pruritus.

e. Skin discoloration ranging from pink to brownish-black.

7 / 65

7) Which statement is true about pharmacokinetic of Dapsone?

a. . Major portion of the drug is excreted in feces.

b. . It is slowly released from the deposits.

c. . Skin heavily infected with M leprae may contain more drug

d. . Absorption from the gut is variable.

e. . Half-life may be 2 months.

8 / 65

8) Isoniazid may cause peripheral neuropathy and anaemia as its side effects because

a. . It interferes with pyridoxine metabolism and induces its deficiency.

b. . It prevents absorption of iron and ascorbic acid.

c. . It is a type of hypersensitivity reaction.

d. . It is toxic to nerves and to red blood cells.

9 / 65

9) What is the Mechanism of action of Dapsone against Mycobacterium leprae?

a. . Inhibits RNA synthesis.

b. . Inhibits mycobacterial arabinosyltransferases.

c. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

d. . Inhibition of neutrophil and eosinophil myeloperoxidase

e. . Inhibition of dihydropteroate synthase

10 / 65

10) What is the most common adverse reactions of INH?

a. . Flu-like syndrome and thrombocytopenia

b. . Ototoxic and Nephrotoxic.

c. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. . The risk of peripheral neuropathy

e. . Harmless orange color to urine, sweats, tears, and contact lenses.

11 / 65

11) Which of the following drugs may cause “risk of postnatal haemorrhage”?

a. . Dapsone

b. . Minocycline

c. . Clarithromycin

d. . Clofazimine

e. . Rifampicin

12 / 65

12) What is the recommended standard treatment duration for leprosy?

a. . 6 or 8 months depending on the operational or clinical classification of the disease

b. . 6 or 12 months depending on the operational or clinical classification of the disease

c. . 6 months for children and 12 months for adults

d. . 12 or 18 months depending on the operational or clinical classification of the disease

e. . 1 or 2 months depending on the operational or clinical classification of the disease

13 / 65

13) WHO regime for paucibacillary leprosy (PB) in adult is:

a. . 100mg Dapsone daily + 600mg Rifampicn daily

b. . 100mg Dapsone daily + 600mg Rifampicin monthly

c. . 50mg Dapsone daily + 450mg Rifampicn monthly

d. . 100mg Dapsone + 600mg Rifampcin + 300mg Clofazimine daily

e. . 300mg Clofazimine daily + 300mg Rifampcin daily

14 / 65

14) What is the most common toxicity of streptomycin?

a. . Ototoxic and Nephrotoxic.

b. . Immunologic Reactions, Hepatitis and Peripheral neuropathy.

c. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. . Hyperuricemia may provoke acute gouty arthritis.

e. . Rashes, thrombocytopenia, and nephritis.

15 / 65

15) What is the most common adverse reactions of Rifampicin?

a. . Loss of visual acuity and red-green color blindness

b. . Hemolysis, particularly if they have G6PD deficiency

c. . Harmless orange color to urine, sweats, tears, and contact lenses

d. . Gastrointestinal intolerance occurs occasionally

e. . Methemoglobinemia is common

16 / 65

16) What is the common adverse reactions of Rifampicin?

a. . Hemolysis, particularly if they have G6PD deficiency

b. . Skin discoloration ranging from red-brown to nearly black

c. . Erythema nodosumleprosum

d. . Hyperuricemia may provoke acute gouty arthritis

e. . Flu-like syndrome and thrombocytopenia

17 / 65

17) What is the recommended standard treatment duration for leprosy?

a. 6 or 12 months depending on the operational or clinical classification of the disease

b. 6 months for children and 12 months for adults

c. 1 or 2 months depending on the operational or clinical classification of the disease

d. 6 or 8 months depending on the operational or clinical classification of the disease

e. 12 or 18 months depending on the operational or clinical classification of the disease

18 / 65

18) A patient taking Anti-leprosy treatment, then he has “hemolytic anemia”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Clofazimine

c. . Dapsone

d. . Minocycline

e. . Clarithromycin

19 / 65

19) Which statement is true about pharmacokinetic of Dapsone?

a. . Cross the placenta, and is found in human breast milk

b. . Half-life may be 2 months.

c. . Excretion into bile and urine

d. . Major portion of the drug is excreted in feces.

e. . It is slowly released from the deposits.

20 / 65

20) 4. What is the Mechanism of action Rifampicin against TB?

a. . Inhibits RNA synthesis.

b. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

c. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

d. . Inhibits synthesis of mycolic acids.

e. . Inhibits mycobacterial arabinosyltransferases.

21 / 65

21) Isoniazid may cause peripheral neuropathy and anaemia as its side effects because

a. It is toxic to nerves and to red blood cells.

b. It interferes with pyridoxine metabolism and induces its deficiency.

c. It prevents absorption of iron and ascorbic acid.

d. It is a type of hypersensitivity reaction.

22 / 65

22) Which statement is the mechanism of actionof Clofazimine?

a. . Inhibition of neutrophil and eosinophil myeloperoxidase

b. . Inhibition of mycobacterial growth and binds preferentially to mycobacterial DNA

c. . Inhibition of RNA synthesis.

d. . Inhibition of dihydropteroate synthase

e. . Inhibition of mycobacterial arabinosyltransferases

23 / 65

23) Which of the following drugs, inhibits mycobacterial arabinosyl transferases?

a. . Ethambutol

b. . Isoniazid

c. . Streptomycin

d. . Rifampin

e. . Pyrizinamide

24 / 65

24) Which statement is true about pharmacokinetic of Dapsone? Choose one best answer.

a. It is slowly released from the deposits.

b. Absorption from the gut is variable.

c. Major portion of the drug is excreted in feces.

d. Skin heavily infected with M leprae may contain more drug

e. Half-life may be 2 months.

25 / 65

25) Which statement is true about Pharmacokinetics of Pyrazinamide? Choose one best answer.

a. Half-life: 3-4 h, metabolized by the liver, about 20% is excreted unchanged in the feces.

b. Half-life: 8-11h, not metabolized in the body and eliminate with active form.

c. Half-life: 3-5 h, metabolized by the liver, about 20% is excreted unchanged in the feces.

d. Half-life: 8-11h, metabolized by the liver, excreted in the urine.

26 / 65

26) What is the most common adverse reactions of Rifampicin? Choose one best answer.

a. Ototoxic and Nephrotoxic.

b. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

c. Lupus-like syndrome, pellagra, arthralgia

d. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

e. Harmless orange color to urine, sweats, tears, and contact lenses.

27 / 65

27) Pyridoxine is given to a patient of tuberculosis prevents

a. . Streptomycin induced nephrotoxicity

b. . Ethambutol induced visual defects

c. . Rifampicin induced hepatotoxicity

d. . Pyrazinamide induced neurotoxicity

e. . INH induced peripheral neuritis

28 / 65

28) A young female patient using an oral contraceptive is to be treated for leprosy. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes:

a. . Ofloxacin

b. . Rifampicin

c. . Clofazimine

d. . Minocycline

e. . Dapsone

29 / 65

29) A young female patient using an oral contraceptive is to be treated for pulmonary tuberculosis. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes:

a. . Rifampicin

b. . Streptomycin

c. . Isoniazid

d. . Ethambutol

e. . Pyrazinamide

30 / 65

30) Which statement is the adverse reaction of Clofazimine?

a. . Ichthyosis and dryness

b. . Erythema nodosumleprosum

c. . Hemolysis, particularly if they have G6PD deficiency

d. . Gastrointestinal intolerance, fever, pruritus.

e. . Methemoglobinemia is common, but usually is not a problem clinically

31 / 65

31) Which statement is true about pharmacokinetic of Clofazimine?

a. . Skin heavily infected with M leprae may contain several times more drug than normal skin

b. . Cross the placenta, and is found in human breast milk

c. . Cross the blood-brain barrier

d. . Metabolism: not known

e. . Half-life may be 2 months

32 / 65

32) Which statement is the adverse reaction of Clofazimine?

a. . Skin discoloration ranging from pink to brownish-black

b. . Gastrointestinal intolerance, fever, pruritus.

c. . Methemoglobinemia is common, but usually is not a problem clinically

d. . Erythema nodosumleprosum

e. . Hemolysis, particularly if they have G6PD deficiency

33 / 65

33) A patient taking Anti-leprosy treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Dapsone

c. . Minocycline

d. . Ofloxacin

e. . Clofazimine

34 / 65

34) Which statement is true about pharmacokinetic of Rifampicin?

a. . It is slowly released from the deposits.

b. . Excreted in the feces, small amount in the urine

c. . Skin heavily infected with M leprae may contain more drug

d. . Half-life may be 2 months.

e. . Major portion of the drug is excreted in feces.

35 / 65

35) What is the most common adverse reactions of Pyrazinamide? Choose one best answer.

a. Ototoxic and Nephrotoxic.

b. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

c. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. Harmless orange color to urine, sweats, tears, and contact lenses.

e. Hyperuricemia may provoke acute gouty arthritis.

36 / 65

36) What is the most common adverse reactions of EMB ?

a. . Ototoxic and Nephrotoxic.

b. . Harmless orange color to urine, sweats, tears, and contact lenses.

c. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. . Acute gouty arthritis.

e. . Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

37 / 65

37) What is the common adverse reactions of Dapsone?

a. . Methemoglobinemia

b. . Ototoxic and Nephrotoxic

c. . Harmless orange color to urine, sweats, tears, and contact lenses

d. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness

e. . Hyperuricemia may provoke acute gouty arthritis

38 / 65

38) A patient taking Anti-leprosy treatment, then he come back because his skin is dusty, his tongue and lips are blue. He has headache and also tired because of you. His SaO2 is low. Which is the following drugs my cause this side effects?

a. . Dapsone

b. . Clofazimine

c. . Minocycline

d. . Rifampicin

e. . Clarithromycin

39 / 65

39) Which of the following drugs, inhibits mycobacterial arabinosyl transferases? Choose one best answer.

a. Rifampin

b. Isoniazid

c. Pyrizinamide

d. Streptomycin

e. Ethambutol

40 / 65

40) WHO regime for paucibacillary leprosy (PB) in adult is:

a. 100mg Dapsone + 600mg Rifampcin + 300mg Clofazimine daily

b. 300mg Clofazimine daily + 300mg Rifampcin daily

c. 50mg Dapsone daily + 450mg Rifampicn monthly

d. 100mg Dapsone daily + 600mg Rifampicn daily

e. 100mg Dapsone daily + 600mg Rifampicin monthly

41 / 65

41) A patient taking Anti-leprosy treatment, then he has symptoms as “Blurred vision, paraesthesia”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Dapsone

c. . Clofazimine

d. . Minocycline

e. . Clarithromycin

42 / 65

42) A patient taking Anti-tuberculosis treatment, then he has an symptoms as “peripheral neuropathy. Which one of the following medicines can cause this adverse reaction?

a. . Isoniazid

b. . Streptomycin

c. . Ethambutol

d. . Rifampicin

e. . Pyrizinamide

43 / 65

43) What is the Mechanism of action Ethambutol against TB? Choose one best answer.

a. Inhibits synthesis of mycolic acids.

b. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. Inhibits RNA synthesis.

d. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

e. Inhibits mycobacterial arabinosyltransferases.

44 / 65

44) Dose of Rifampicin recommended in multibacillary leprosy in adult is 600 mg

a. . Once in a week

b. . Twice monthly

c. . Once daily

d. . Once in a month

e. . Twice weekly

45 / 65

45) A patient taking Anti-tuberculosis treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction?

a. . Isoniazid

b. . Pyrizinamide

c. . Streptomycin

d. . Ethambutol

e. . Rifampicin

46 / 65

46) What is the most common toxicity of Streptomycin? Choose one best answer.

a. Hyperuricemia may provoke acute gouty arthritis.

b. Ototoxic and Nephrotoxic.

c. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. Immunologic Reactions, Hepatitis and Peripheral neuropathy.

e. Rashes, thrombocytopenia, and nephritis.

47 / 65

47) The primary reason for the use of drug combinations in the treatment of tuberculosis is to

a. Enhance activity against metabolically inactive mycobacteria.

b. Reduce the incidence of adverse effects.

c. Delay or prevent the emergence of resistance.

d. Ensure patient compliance with the drug regimen.

e. Provide prophylaxis against other bacterial infections.

48 / 65

48) What is the Mechanism of action Rifampicin against TB? Choose one best answer.

a. Inhibits synthesis of mycolic acids.

b. Inhibits mycobacterial arabinosyltransferases.

c. Inhibits RNA synthesis.

d. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

e. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

49 / 65

49) A patient taking Anti-tuberculosis treatment, then he has a symptom as “peripheral neuropathy. Which one of the following medicines can cause this adverse reaction? Choose one best answer.

a. Rifampicin

b. Streptomycin

c. Ethambutol

d. Pyrizinamide

e. Isoniazid

50 / 65

50) Pyridoxine is given to a patient of tuberculosis prevents

a. INH induced peripheral neuritis

b. Rifampicin induced hepatotoxicity

c. Streptomycin induced nephrotoxicity

d. Ethambutol induced visual defects

e. Pyrazinamide induced neurotoxicity

51 / 65

51) A patient taking Anti-leprosy treatment, then he has “Erythema nodosum leprosum”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Dapsone

c. . Clofazimine

d. . Minocycline

e. . Clarithromycin

52 / 65

52) A patient taking Anti-leprosy treatment, then he has symptoms as “Ichthyosis and dryness”. Which one of the following medicine can cause this adverse reaction?

a. . Clofazimine

b. . Dapsone

c. . Rifampicin

d. . Minocycline

e. . Clarithromycin

53 / 65

53) What is the Mechanism of action of Rifampicin against Mycobacterium leprae?

a. . Inhibits bacterial DNA-dependent RNA synthesis

b. . Inhibition of dihydropteroate synthase

c. . Inhibits mycobacterial arabinosyltransferases

d. . Inhibition of neutrophil and eosinophil myeloperoxidase

e. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

54 / 65

54) A patient taking Anti-tuberculosis treatment, then he has symptoms as “arthralgia with biological sign of Hyperuricemia”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Ethambutol

c. . Pyrizinamide

d. . Isoniazid

e. . Streptomycin

55 / 65

55) A patient taking Anti-leprosy treatment, then he has symptoms as “Flu-like syndrome and thrombocytopenia”. Which one of the following medicine can cause this adverse reaction?

a. . Minocycline

b. . Dapsone

c. . Clofazimine

d. . Rifampicin

e. . Clarithromycin

56 / 65

56) Skin pigmentation and icthyosis like side effects are seen in patient who received:

a. . Clofazimine

b. . Thalidomide

c. . Steroid

d. . Rifampcin

e. . Dapsone

57 / 65

57) The primary reason for the use of drug combinations in the treatment of tuberculosis is to:

a. . Reduce the incidence of adverse effects.

b. . Enhance activity against metabolically inactive mycobacteria.

c. . Delay or prevent the emergence of resistance.

d. . Ensure patient compliance with the drug regimen.

e. . Provide prophylaxis against other bacterial infections.

58 / 65

58) What is the most common adverse reactions of Isoniazid? Choose one best answer.

a. Ototoxic and Nephrotoxic.

b. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. The risk of peripheral neuropathy

d. Harmless orange color to urine, sweats, tears, and contact lenses.

e. Flu-like syndrome and thrombocytopenia

59 / 65

59) A patient taking Anti-tuberculosis treatment, then he has symptoms as “arthralgia with biological sign of Hyperuricemia”. Which one of the following medicine can cause this adverse reaction? Choose one best answer.

a. Pyrizinamide

b. Ethambutol

c. Isoniazid

d. Streptomycin

e. Rifampicin

60 / 65

60) Which statement is true about pharmacokinetic of Clofazimine?

a. . Cross the blood-brain barrier

b. . Skin heavily infected with M leprae may contain more drug

c. . Excreted in the feces, small amount in the urine

d. . Excreted in urine

e. . Half-life is variable, with values as long as 70 days.

61 / 65

61) A patient taking Anti-tuberculosis treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction? Choose one best answer.

a. Ethambutol

b. Pyrizinamide

c. Isoniazid

d. Rifampicin

e. Streptomycin

62 / 65

62) A young female patient using an oral contraceptive is to be treated for pulmonary tuberculosis. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes

a. Pyrazinamide

b. Streptomycin

c. Rifampicin

d. Ethambutol

e. Isoniazid

63 / 65

63) Which statement is “correct” about adverse reactions of Dapsone? Choose one best answer.

a. Skin discoloration ranging from red-brown to nearly black.

b. Gastrointestinal intolerance occurs occasionally.

c. It may cause cholestatic jaundiceand occasionally hepatitis

d. Loss of visual acuity and red-green color blindness.

e. Methemoglobinemia is common.

64 / 65

64) What is the most common adverse reactions of Ethambutol? Choose one best answer.

a. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

b. Harmless orange color to urine, sweats, tears, and contact lenses.

c. Acute gouty arthritis.

d. Ototoxic and Nephrotoxic.

e. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

65 / 65

65) What is the Mechanism of Action of INH against M tuberculosis?

a. . Inhibits synthesis of mycolic acids.

b. . Inhibits RNA synthesis.

c. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

d. . Inhibits mycobacterial arabinosyltransferases.

e. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

Your score is

The average score is 69%

Any comments?

Any problems/errors or mistakes found while testing, please let us know for modification!

និស្សិតអាចប្រាប់មកកាន់ពួកយើងបានដើម្បីកែកំហុស ឬអំពីបញ្ហាដោយអចេតនាណាមួយដែលកើតមានកំឡុងពេលធ្វើតេស្ត