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Immunologie GΓ©nΓ©rale Et AppliquΓ©e Preparation (Dr. Ly Nary)

 

1 / 50

1)

Most naïve T cell activation occurs where and in response to what?

2 / 50

2)

Which one of the following is a primary lymphoid organ?

3 / 50

3)

At the peak of a CD8+ T cell response to a new microbe, what is the fold increase in the number of microbe-specific T cells in an individual compared to the number of naïve CD8+ T cells specific for the microbe before infection?

4 / 50

4)

The germinal center is an important site of?

5 / 50

5)

Which type of T cell lyses cells that have been infected with viruses?

6 / 50

6)

A standard treatment of animal bite victims, when there is a possibility that the animal was infected with the rabies virus, is administration of human immunoglobulin preparations containing anti–rabies virus antibodies. Which type of immunity would be stablished by this treatment?

7 / 50

7)

In both B and T cell development, there is stage when a pre-antigen receptor (pre B cell receptor or pre T cell receptor) is expressed. Which of the following accurately describes an important function of these pre-antigen receptors?

8 / 50

8)

Which of the following cell types is NOT known to act as an antigen-presenting cell for CD4+ T cells?

9 / 50

9)

Which of the following statements regarding the functional properties of cytokines is false?

10 / 50

10) previously healthy 8-year-old boy is infected with an upper respiratory tract virus for the first time. During the first few hours of infection, which one of the following events occurs?

11 / 50

11)

Neutrophils?

12 / 50

12)

Which of the following mechanisms contributes most to both Ig and TCR diversity?

13 / 50

13)

The paracortical area of a lymph node comprises mainly?

14 / 50

14)

Which enzyme contributes to antigen receptor junctional diversity by adding random nucleotides at the junctions between V, D, and J segments and is also useful as a marker of neoplasia of pro-B and pro- T cells?

15 / 50

15)

In DiGeorge syndrome, the thymus fails to develop. Which of the following characterizes the immunodeficiency state in this syndrome?

16 / 50

16)

The germinal center reaction generates long lived plasma cells which secrete protective high affinity B cells for many years. Where do these cells reside?

17 / 50

17)

A vaccine administered in the autumn of one year may protect against the prevalent strain of influenza virus that originated in Hong Kong that same year, but it will not protect against another strain of influenza virus that originated in Russia. This phenomenon illustrates which property of the adaptive immune system?

18 / 50

18)

All secondary lymphoid tissues?

19 / 50

19)

Which of the following molecules or molecular complexes functions to display foreign antigens on the surface of cells?

20 / 50

20)

The spleen is largely involved with the response to antigens which are in the?

21 / 50

21)

Tissue macrophages are derived from which type of circulating blood cell?

22 / 50

22)

Langerhans’ cells are found in?

23 / 50

23)

Cytokines attract which of the following to the affected tissue?

24 / 50

24)

A drug that blocks the function of the chemokine receptor CCR7 would result in which of the following abnormalities?

25 / 50

25)

Plasma cells?

26 / 50

26)

Lymphocytes?

27 / 50

27)

T-lymphocytes recognize antigen?

28 / 50

28)

The secondary, but not the primary, immune response is based on?

29 / 50

29)

At 15 months of age, a child received a measles-mumps-rubella vaccine (MMR). At age 22, she is living with a family in Mexico that has not been vaccinated and she is exposed to measles. Despite the exposure, she does not become infected. Which of the following properties of the adaptive immune system is best illustrated by this scenario?

30 / 50

30)

IL-1, IL-6, and TNF- are proinflammatory cytokines that are known to?

31 / 50

31)

The proteins secreted by plasma cells are called?

32 / 50

32)

What kind of cell is most numerous in the periarterial lymphatic sheath (PALS) of the spleen?

33 / 50

33)

Which of the following cell types is a phagocyte?

34 / 50

34)

Precursors of macrophages are called?

35 / 50

35)

Where B lymphocytes mature?

36 / 50

36)

According to the clonal selection hypothesis, which of the following is correct?

37 / 50

37)

The most important costimulators for naïve T cell activation are which of the following?

38 / 50

38)

Which of the following is not a function of the innate immune system?

39 / 50

39)

Antigen-presenting cells?

40 / 50

40)

Which of the following can be accurately called a cytokine?

41 / 50

41)

Clonal selection occurs when a B-lymphocyte encounters?

42 / 50

42)

When antigens enter through the skin, in what organs are they concentrated?

43 / 50

43)

Which subsets of T cells recognize antigens presented by class II MHC molecules?

44 / 50

44)

During the negative selection of T-cells in the thymus?

45 / 50

45)

The secretion of antibodies by lymphocyte B cells provides?

46 / 50

46)

When a B-lymphocyte encounters a foreign antigen with the appropriate specificity?

47 / 50

47)

A one year old boy with a history of severe infections is found to have very few circulating mature T cells or NK cells, but normal numbers of B cells. Genetic studies reveal he has X-linked severe combined immunodeficiency syndrome. Defective signaling by the receptor for which cytokine is the underlying cause of this disease?

48 / 50

48)

The site of T-cell maturation is the?

49 / 50

49)

A 5-year-old boy with recurrent infections is discovered to have a genetic defect that impairs B cell maturation. Which of the following abnormalities is most likely to be found in this patient?

50 / 50

50)

A 52-year-old man who receives radiation therapy and cytotoxic drugs for treatment of cancer sustains significant damage to his bone marrow. Which of the following changes will most likely occur?

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