Immunologie Générale Et Appliquée Test

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1 / 60

IL-1, IL-6, and TNF- are proinflammatory cytokines that are known to?

a. Initiate acute-phase responses.

b. Act in concert with chemokines to promote migration of inflammatory cells to sites of infection.

c. Cause increased vascular permeability.

d. All of the above

2 / 60

T-lymphocytes recognize antigen?

a. Presented by MHC molecules on other cells

b. By endocytosing and partially digesting it

c. Only if it has been present in the thymus during maturation of the T-cell

d. If it occurs in a free molecular state

3 / 60

In DiGeorge syndrome, the thymus fails to develop. Which of the following characterizes the immunodeficiency state in this syndrome?

a. Defect in naive B cell activation and antibody production in response to bacterial polysaccharides

b. Deficiency in T lymphocytes and associated defects in cell-mediated immunity

c. Deficiency in B cell maturation

d. Deficiency in monocytes and tissue macrophages

4 / 60

Where B lymphocytes mature?

a. Lymph nodes

b. Bone marrow

c. Spleen

d. Thymus

5 / 60

When antigens enter through the skin, in what organs are they concentrated?

a. Bone marrow

b. Thymus

c. Skin-draining lymph nodes

d. Spleen

6 / 60

Which subsets of T cells recognize antigens presented by class II MHC molecules?

a. Natural killer T cells

b. CD8+ cytotoxic T cells

c. Memory T cells

d. CD4+ helper T cells

7 / 60

Clonal selection occurs when a B-lymphocyte encounters?

a. Cytokines

b. T-lymphocytes

c. Complement

d. Antigen

8 / 60

Which of the following is not a function of the innate immune system?

a. Respond to microbial infections by inducing expression of T cell costimulators on antigen presenting cells

b. Rapidly respond to microbial infections by promoting acute inflammation

c. Respond to microbial infections by inducing a state of long lived memory that prevents repeat infections by the same microbe

d. Respond to damaged and dying host cells by inducing acute inflammation

9 / 60

Precursors of macrophages are called?

a. killer cells

b. Monocytes

c. T cells

d. Plasma cells

10 / 60

During the negative selection of T-cells in the thymus?

a. T-cells that recognize "self" antigens undergo apoptosis

b. T-cells with CD-8 receptors on their surface undergo apoptosis

c. A majority of the cells survive to enter the circulation

d. The surviving T-cells migrate to the bone marrow

11 / 60

A 52-year-old man who receives radiation therapy and cytotoxic drugs for treatment of cancer sustains significant damage to his bone marrow. Which of the following changes will most likely occur?

a. Decreased production of monocytes but not B lymphocytes

b. Decreased production of B and T lymphocytes, monocytes, neutrophils and red blood cells

c. Decreased production of neutrophils and monocytes but not B lymphocytes

d. Decreased production of B lymphocytes but not T lymphocytes

12 / 60

A one year old boy with a history of severe infections is found to have very few circulating mature T cells or NK cells, but normal numbers of B cells. Genetic studies reveal he has X-linked severe combined immunodeficiency syndrome. Defective signaling by the receptor for which cytokine is the underlying cause of this disease?

a. IL-2

b. IL-4

c. IL-1

d. IL-7

13 / 60

marqueur របស់ lymphocyte B

a. CD19

b. CMH classe II

c. CD56

d. CD16

14 / 60

Interleukine 2 (IL-2) សំយោគដោយៈ

a. lymphocyte T

b. macrophage

c. Éosinophile

d. lymphocyte B

15 / 60

តើប្រយោគណាមួយខាងក្រោមដែលមិនត្រឹមត្រូវ ទាក់ទងនឹង IgG?

a. ឆ្លងកាត់ placenta

b. មាន affinité élevé dans la réponse immunitaire primaire

c. អាចភ្ជាប់ នឹង complément

d. neutralise សារធាតុពុល របស់បាក់តេរី

16 / 60

Cytokine ដែលមានតួនាទីសំរាប់ la survie de lymphocytes T:

a. IL-10

b. IL-2

c. IL-18

d. IL-12

17 / 60

វ៉ាក់សាំង virus vivant atténué est indiqué សំរាប់

a. អ្នកជំងឺដែលស្ថិតក្រោមការព្យាបាល ដោយ corticoïde ឬ radiothérapie

b. អ្នកជំងឺ leucémie

c. ស្ដ្រីមានផ្ទៃពោះ

d. ក្មេង អាយុក្រោម ៨ ឆ្នាំ

18 / 60

Au cours de la réaction immunitaire ។ ពពួក macrophages :

a. ផលិត IL-2

b. ផលិត IL-1

c. បំផ្លាញ cellule infectée via activité cytotoxique directe

d. ផលិត protéine C réactif

19 / 60

protéine C réactif ត្រូវបានផលិតដោយសារ

a. TGF beta

b. IL-10

c. IL-12

d. IL-6

20 / 60

តើម៉ូលេគុលណាមួយជាម៉ូលេគុលរបស់ HLA classe II:

a. HLA-C

b. HLA-DR

c. HLA-B

d. HLA-A

21 / 60

marqueur របស់ Lymphocyte T helper

a. CD4

b. CD28

c. CD25

d. CD8

22 / 60

lymphocyte T ចូលមកក្នុង ganglion lymphatique via:

a. Zone de lymphocyte T de région para cortical du ganglion lymphatique

b. vaisseaux lymphatique afférente

c. capillaire lymphatique

d. HEV

23 / 60

កោសិកាដែលមានសកម្មភាព cytotoxique គឺ:

a. Plasmocyte

b. Composants C5-C9 de complément

c. Cellule Natural Killer

d. Les granulocytes

24 / 60

Récepteur de lymphocyte B គឺ:

a. Immunoglobuline M membranaire

b. récepteur de C3a

c. récepteur de វីរុស Epstein-Barr

d. អង្កត់ Fc របស់ IgM

25 / 60

TLR-4 (Toll Like Receptor-4) ជា pattern recognition receptor) ដែលស្គាល់ៈ

a. motif CpG

b. lipopolysaccharide

c. Peptidoglycan

d. ARN double brin

26 / 60

ម៉ូលេគុលដែលបង្ហាញនៅលើផ្ទៃភ្នាសរបស់ lymphocyte T CD4 ដែលភ្ជាប់ទៅនឹងម៉ូលេគុល B7 គឺ :

a. ICAM-1

b. CD56

c. CD38

d. CD28

27 / 60

The Adverse events following immunization (AEFI) are divided into:

a. 6 categories

b. 3 categories

c. 4 categories

d. 5 categories

28 / 60

The immunoglobulins participated in complement system formation are:

a. Ig G and Ig M

b. Ig G and Ig E

c. Ig G and Ig A

d. Ig D and Ig M

29 / 60

The class of immunoglobulin present in highest concentration in blood of a human newborn is:

a. Ig D

b. Ig G

c. Ig A

d. Ig M

30 / 60

For vaccination against mycobacterial diseases such as tuberculosis, the most important facet of the immune response to be stimulated is:

a. Macrophage-activating cell-mediated immunity

b. Cytotoxic T-cells

c. Antibody in the gut lumen

d. A high titer of antibody

31 / 60

The immunoglobulins transport across epithelium:

a. Ig A and Ig G

b. All immunoglobulins

c. Ig A, Ig M

d. Ig A, Ig M and Ig G

32 / 60

All are mechanism of action of complement but except:

a. Opsonin

b. Decrease in vascular permeability

c. Recruitment and activation of phagocytic cells

d. Lysis of bacteria and some viruses

33 / 60

Which of the following immune cells/ molecules are most effective at destroying intracellular pathogens?

a. B cells

b. Complement

c. Cytotoxic T cells

d. Helper T cells

34 / 60

The immune cells that is linked between innate and adaptive immunity are:

a. Macrophages

b. T cytotoxic cells

c. NK T-cells

d. T helper cells

35 / 60

Which of the following is not an ideal property of a vaccine?

a. Safety

b. Reusability

c. Stability

d. Affordability

36 / 60

An epitope is:

a. antigen determinant site

b. a hapten

c. a B-cell

d. an antibody

37 / 60

To which one of the following groups would it be acceptable to give a live attenuated viral vaccine?

a. Patients treated with radiotherapy

b. Pregnant mothers

c. Patients treated with steroids

d. Children under 8 years of age

38 / 60

The ideal storage conditions of adjuvanted vaccines in a refrigerator are between:

a. 2 degree to 8 degree

b. 0 degree to 3 degree

c. 1 degree to 3 degree

d. 5 degree to 10 degree

39 / 60

The complement system involved in chemotaxis are:

a. C3 and C4

b. C3a and C5a

c. C3a, C4a and C5a

d. C3b and C5b

40 / 60

Which of the following immune mechanism is responsible for protecting us from diseases of other species?

a. Passive immunity

b. Innate immunity

c. Adaptive immunity

d. Active immunity

41 / 60

The naive T cells are:

a. Immature recirculating T cells that have not yet encountered their antigens

b. Mature suppressor T cells that have not yet encountered their antigens

c. Mature T cells that located in germinal centre of lymph node

d. Mature recirculating T cells that have not yet encountered their antigens

42 / 60

Which of the following antibody types forms a pentamer?

a. Ig G

b. Ig D

c. Ig A

d. Ig M

43 / 60

The role of the macrophage during an antibody response is to:

a. Lyse virus-infected target cells

b. Process antigen and present it

c. Make antibody

d. Activate cytotoxic T cells

44 / 60

The classical pathway of complement activation is:

a. Ig G pathway

b. Ig E pathway

c. Lectin pathway

d. Toxins pathway

45 / 60

A patient presents with an increased number of lymphocytes in his peripheral blood. Which of the following is an appropriate technique to find out which type of lymphocytes these are?

a. Enzyme-linked immunosorbent assay (ELISA)

b. Radioimmunoassay (RIA)

c. Flow cytometric analysis

d. Western blotting

46 / 60

HBV vaccine and HBIG are given at same time at two different injection sites within:

a. 24-48 h of delivery

b. 1 week of delivery

c. 12-24 h of delivery

d. 48-72 h of delivery

47 / 60

During the maturation of a B lymphocyte, the first immunoglobulin heavy chain synthesized is:

a. Gamma chain

b. Alpha chain

c. Mu chain

d. Epsilon chain

48 / 60

What is the immune cell in adaptive immunity?

a. Mast Cell

b. Plasma cell

c. Antigen presenting cells

d. Macrophage

49 / 60

Graft and tumor rejection are mediated primarily by:

a. Non–complement-fixing antibodies

b. Cytotoxic T cells

c. Helper T cells

d. Phagocytic cells

50 / 60

What vaccine should not be frozen:

a. Adjuvanted Vaccine

b. Chickenpox vaccine

c. Live attenuated vaccine

d. MMR vaccine

51 / 60

Which of the following statement is true

a. All immunogens are not antigens but all antigens are immunogens

b. All immunogens are antigens and all antigens are immunogens

c. All immunogens are antigens but all antigens are not immunogens

d. All immunogens are proteins and all proteins are immunogens

52 / 60

The following statements are related to hepatitis B and pregnancy which statement is incorrect?

a. Both active and passive immunizations are used for HBsAg-positive mothers

b. HBV vaccine and HBIG are given at same time to 2 sites in 12-24 h of delivery

c. Three possible routes for transmission of HBV: Transplacental, Natal and Horizontal

d. The infants then receive two additional doses of HBV vaccine at ages 1-2 M & 6-8 M

53 / 60

Which of the following is a polysaccharide vaccine:

a. Hepatitis A

b. Hib vaccine

c. Rabies vaccine

d. Anthrax vaccine

54 / 60

Natural humoral immune response against a pathogen leads to the production of:

a. Monoclonal antibodies

b. Antigen presenting cells

c. Polyclonal antibodies

d. Macrophages

55 / 60

Small chemical groups on the antigen molecule that can react with antibody

a. Epitope

b. Paratope

c. Isotope

d. Allotope

56 / 60

Which of the following is the site of T cell maturation?

a. Thymus

b. Appendix

c. Bone marrow

d. Spleen

57 / 60

Which of the following statement is true regarding vaccination:

a. Vaccination is a method of natural passive

b. Vaccination is a method of active immunization

c. Vaccination is a method of passive immunization

d. Vaccination is a method of artificial passive immunization

58 / 60

Hemolytic disease of the newborn caused by Rh blood group incompatibility requires maternal antibody to enter the fetal bloodstream. Therefore, the mediator of this disease is:

a. Ig E antibody

b. Ig G antibody

c. Ig A antibody

d. Ig M antibody

59 / 60

Adjuvant used in HBV vaccine is:

a. Monophosphoryl lipide A (MPL)

b. Calcium phosphate

c. Aluminium phosphate (AlPO4)

d. Liposome

60 / 60

An immunoglobulin is a:

a. Protein

b. Glycoprotein

c. Polysaccharide

d. Glycolipid

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Immunologie Générale Et Appliquée Test

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និស្សិតអាចប្រាប់មកកាន់ពួកយើងបានដើម្បីកែកំហុស ឬអំពីបញ្ហាដោយអចេតនាណាមួយដែលកើតមានកំឡុងពេលធ្វើតេស្ត