Immunologie Générale Et Appliquée Test

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1 / 60

Which of the following best explains the reaction that takes in the latex agglutination slide test for CRP?

a. Latex particles are coated with anti-CRP.

b. CRP is acting as an antibody

c. Latex particles are coated with CRP.

d. Latex particles are nonspecifically bound.

2 / 60

Peptides antigens generated in the cytosolic compartment (intracellular infection, e.g. virus) bind to ____ MHC molecules for presentation to ____ T cells. Peptide antigens generated in vesicles (extracellular infection, e.g. bacteria) bind to ____ MHC molecules for presentation to ____ T cells.

a. Class II; CD4+; Class I; CD8+

b. Class I; CD4+; Class II; CD8+

c. Class I; CD8+; Class II; CD4+

d. Class II; CD8+; Class I; CD4+

3 / 60

A serological reaction is set up in which the antigen is coated to larger carrier (particle), the antibody is soluble , and they bind and form an insoluble complex that is detected macroscopically. What type of assay is described?

a. Precipitation

b. Immunofluorescent

c. ELISA

d. Agglutination

4 / 60

All of the following are functions of IgG EXCEPT

a. Cross the placenta

b. Opsonize bacteria.

c. Facilitate ADCC

d. Be secreted into mucus

5 / 60

Which of the following can activate the alternative complement pathway ?

a. C3b

b. IgD

c. IgG

d. Ciq

6 / 60

Which of the following molecules is necessary (not accessory) for antigen recognition and T cell activation?

a. CD2

b. CD3

c. CD28

d. CD45R

7 / 60

When IgM on the surface of an immature B cell binds to a self-antigen , which of the following processes can occur ?

a. Differentiation

b. Apoptosis

c. Class switch

d. Affinity maturation

8 / 60

Which of the following components of the i nnate immune system involves cytokines produced by macrophages , which are produced during infection ?

a. Interferons

b. Oxygen dependent and independent killing

c. Complement system

d. Acute phase proteins

9 / 60

What types of professional APC cell that MHC-II present antigen to T H n a ïve ?

a. Essentially cells

b. Dendritic cells

c. B cells

d. Macrophages

10 / 60

Which transplant method would prevent the rejection of tissue after and organ transplant?

a. Using organs only from pigs or monkeys

b. Using organs cloned from the cells of the patient

c. Using organs produced by genetic engineering to get rid of all proteins in the donated organs

d. Using an organ donated by a close relative because the proteins will always be identical to those of the patient

11 / 60

Which of the following is NOT true of neutrophils compared with macrophages ?

a. Rapid increase in production during acute response

b. Found in healthy tissues.

c. Is short-lived (dies after phagocytosis)

d. Has a single mature form

12 / 60

Monoclonal antibodies (mAb) are antibodies with a wide range of clinically important applications, such as pregnancy tests, cancer diagnosis, and cancer treatment. These antibodies are ____ and come from ____ parent cell(s).

a. Dissimilar; Multiple

b. Identical; multiple

c. Dissimilar; a single

d. Identical; a single

13 / 60

On a serial dilution with the following tube set u p, 1:2, 1:4, 2:8, 1:16, 1:32, and 1:64 , there is no visible agglutination in the 1:64. What is the titer of the antibody?

a. 32

b. 64

c. Cannot determine

d. 16

14 / 60

A plasma cell secretes:

a. Antibody of a single specificity to antigen

b. Many different types of antibodies

c. Lysozyme

d. Antibody of two antigen specificities

15 / 60

Which of the immunoglobulin that make activates the complement system ?

a. IgG & IgE

b. IgG & IgM

c. IgM & IgD

d. IgG & IgA

16 / 60

Precipitation reactions involve combination of soluble antibody with:

a. Red blood cells

b. Soluble antigen

c. Radioactive antigen

d. Cellular antigens

17 / 60

Which of the following is NOT true when comparing innate to adaptive immunity?

a. Innate response is non-specific and adaptive is very specific

b. Innate does not show response improvements over time and adaptive does

c. Innate has immunologic memory and adaptive does not

d. Innate responds quickly and Adaptive responds slowly

18 / 60

Which of the following is a large genomic region of gene family found in most vertebrates, playing an important role in immunity ?

a. Major histocompatibility complexes (MHC)

b. Human leukocyte antigens (HLA)

c. Immunoglobulin

d. Epitopes

19 / 60

The ______ immune system uses ____ as well as molecules (e.g. complement components). The ____ immune system uses ____ as well as antigen recognition molecules .

a. Adaptive; Phagocytes; Innate; Lymphocytes

b. Innate; Phagocytes; Adaptive; Lymphocytes

c. Innate; Lymphocytes; Adaptive; Phagocytes

d. Adaptive; Lymphocytes; Innate; Phagocytes

20 / 60

Subunit vaccines contains components from pathogens, which are inactivated and referred to as ____. These vaccines are generally of low immunogenicity and may need ____ to work effectively.

a. LPS; Live vaccination

b. Capsules; Homeostasis

c. Toxoids; Adjuvants

d. Cytokines; IgE

21 / 60

Which of the following differentiates an antigen from an immunogen ?

a. An antigen can cause the production of antibodies

b. An antigen does not always elicit an immune response

c. Antigens are usually proteins or polysaccharides

d. An antigen is a foreign molecule

22 / 60

Which of the following is used extensively to detect antigens in cells or tissue sections , as well as to screen for auto-antibodies to cell or tissue antigens?

a. ELISA (Enzyme-linked immunosorbent assay)

b. Western blotting (immunoblotting)

c. Fluorescent antibody (fluorochromes)

d. FACS (fluorescence-activated cell sorting)

23 / 60

A serological test that uses red blood cells coated with exogenous antigens such as bacterial polysaccharides as a method to detect patient antibodies against that exogenous antigen is called:

a. Hemagglutination

b. Complement fixation

c. Latex agglutination

d. Neutralization

24 / 60

Cytotoxic T cells induced by infection with virus A will kill target cells

a. Infected by virus A and identical at class II MHC loci of the cytotoxic T cells.

b. From the same host infected with any virus

c. Infected by virus A and identical at class I MHC loci of the cytotoxic T cells.

d. Infected with virus B and identical at class I MHC loci of the cytotoxic cells.

25 / 60

The Westerm Blot test used to confirm HIV is an example of which of the following?

a. Immunoelectrophoresis

b. Passive agglutination

c. Double diffusion

d. Immunofixation

26 / 60

The expression of cell surface markers is determined in t he flow cytometer by which of the following?

a. Optical density

b. Radioactivity

c. Fluorescence

d. Chemiluminescence

27 / 60

How many genes does MHC-II have ?

a. 2 (HLA-DP alpha/beta)

b. 2 (HLA-DQ alpha/beta)

c. 6 (HLA-DP alpha/beta, HIA-DQ alpha/beta, HLA-DR alpha/beta)

d. 4 (HLA-DQ alpha/beta, HLA-DR alpha/beta)

28 / 60

Which category of hypersensitivity best describes hemolytic disease of the newborn caused by Rh incompatibility?

a. Immune complex

b. Atopic or anaphylactic

c. Cytotoxic

d. Delayed

29 / 60

An immunoglobulin is a:

a. Glycolipid

b. Polysaccharide

c. Glycoprotein

d. Protein

30 / 60

The inability of very young children to respond to the measles vaccine due to the persistence of maternal antibody is similar in principle to and exploited in which of the following?

a. Low dose tolerance regimens

b. Tolerance to self antigens

c. Neonatal inability to respond to T-independent antigens

d. Passive immunization as a means of preventing active sensitization (e.g., Rhogam injections)

31 / 60

For vaccination against mycobacterial diseases such as tuberculosis, the most important facet of the immune response to be stimulated is:

a. Macrophage-activating cell-mediated immunity

b. Cytotoxic T-cells

c. A high titer of antibody

d. Antibody in the gut lumen

32 / 60

What is a live attenuated vaccine?

a. HBV Vaccine

b. DTPa Vaccine

c. MMR Vaccine

d. HPV vaccine

33 / 60

Which of the following is a polysaccharide vaccine:

a. Anthrax vaccine

b. Hib vaccine

c. Rabies vaccine

d. Hepatitis A

34 / 60

The class of immunoglobulin present in highest concentration in blood of a human newborn is

a. Ig M

b. Ig A

c. Ig D

d. Ig G

35 / 60

The immune cells that is linked between innate and adaptive immunity are:

a. B-cells

b. NK T-cells

c. Macrophages

d. T-cells

36 / 60

In the application Antigen- Antibody reaction, which one is correct?

a. Immunofluorescence is used to detect antigen or antibodies

b. Precipitation test is measuring of concentration of antigen and antibody

c. Agglutination reaction is identifying blood grouping and cross matching

d. Radioimmunoassay is to locate and identify antigen in tissues and clinical materials

37 / 60

The first recombinant antigen vaccine approved for human use is:

a. DPT vaccine

b. Hepatitis B vaccine

c. Hib vaccine

d. Var vaccine

38 / 60

The process of weakening a pathogen is called:

a. Virulence reduction

b. Vaccination

c. Immunization

d. Attenuation

39 / 60

The characteristic of antigen-antibody interactions occur in second stage:

a. Lysis of cells and irreversible reaction

b. Rapid and reversible reaction

c. Occurring in vivo and humoral immunity

d. Precipitation reaction The characteristic o

40 / 60

A primary immune response in an adult human requires approximately how much time to produce detectable antibody levels in the blood?

a. 3 days

b. 12 hours

c. 1 week

d. 3 weeks

41 / 60

The complement system consists of about:

a. Twenty immunoglobulins

b. Twenty lymphocytes

c. Twenty plasma proteins

d. Twenty antigens

42 / 60

Newborns get their antibodies from mother’s milk. This is an example of?

a. Naturally acquired passive immunity

b. Artificially acquired active immunity

c. Artificially acquired passive immunity

d. Naturally acquired active immunity

43 / 60

What is the immune cell in adaptive immunity?

a. Plasma cell

b. Macrophage

c. Antigen presenting cells

d. Mast Cell

44 / 60

The immunoglobulins transport across placenta mostly:

a. Ig G1

b. Ig G3

c. Ig G2

d. Ig G4

45 / 60

Natural humoral immune response against a pathogen leads to the production of:

a. Antigen presenting cells

b. Monoclonal antibodies

c. Polyclonal antibodies

d. Macrophages

46 / 60

Injection of immunoglobulin is:

a. Artificial type of active immunity

b. Natural type of passive immunity

c. Natural type of active immunity

d. Artificial type of passive immunity

47 / 60

In the application Antigen- Antibody reaction, which one is not correct?

a. Precipitation test is used to detect antigen or antibodies

b. Radioimmunoassay is measuring of concentration of antigen and antibody

c. Agglutination reaction is used to detect antigen or antibodies

d. Immunofluorescence is to locate and identify antigen in tissues and clinical materials

48 / 60

The general principle of vaccination was established by:

a. Louis Pasteur

b. Joseph Miester

c. Carl Landsteiner

d. dward Jenner

49 / 60

A vaccine that activates both cell- mediated and humoral immunity would most likely be :

a. A virion

b. Live attenuated

c. A toxoid

d. Heat killed

50 / 60

All are important characteristics of innate immunity but except:

a. Activated by cell death

b. Immediate response

c. Specific immunity

d. Exposure does not result in memory

51 / 60

The following statements are related to Rhesus D alloimmunization in pregnancy which statement is incorrect?

a. All Rh(-) pregnant women should do an antibody screen at last semester of prenatal visit

b. Rh(D) positive neonates of these mothers are at risk of developing hemolytic disease

c. Routine administration of anti-D Ig at 28 weeks of gestation or within 72 h of delivery

d. It develops as a result of maternal immune system exposure to Rh(+) RBCs

52 / 60

The immunoglobulins participated in complement system formation are:

a. Ig G and Ig M

b. Ig D and Ig M

c. Ig G and Ig E

d. Ig G and Ig A

53 / 60

ម៉ូលេគុលដែលបង្ហាញនៅលើផ្ទៃភ្នាសរបស់ lymphocyte T CD4 ដែលភ្ជាប់ទៅនឹងម៉ូលេគុល B7 គឺ :

a. CD28

b. CD38

c. ICAM-1

d. CD56

54 / 60

តើម៉ូលេគុលណាមួយជាម៉ូលេគុលរបស់ HLA classe II:

a. HLA-DR

b. HLA-B

c. HLA-C

d. HLA-A

55 / 60

ការឆ្លើយតបរបស់ប្រព័ន្ធភាពសុំា adaptative régulé par:

a. concentration de l’antigène

b. Lymphocyte T régulateur

c. Lymphocyte T régulateur និង concentration de l’antigène.

d. neutrophile

56 / 60

កោសិកា Natural killer

a. មិនធ្វើសកម្មភាព cytolytique

b. មិនមានម៉ូលេគុល CD3 នៅលើផ្ទៃភ្នាសខាងក្រៅ

c. មិនមានម៉ូលេគុល CD56 នៅលើផ្ទៃភ្នាសខាងក្រៅ

d. មាន ម៉ូលេគុល CD3 នៅលើផ្ទៃភ្នាសខាងក្រៅ

57 / 60

réaction immunitaire primaire មានភាពខុសគ្នា នឹង ប្រតិកម្ម secondaire ដោយ :

a. មាន ការផលិត យ៉ាងខ្លាំង នូវបរិមាណ អង្គបដិបក្ខ ប្រភេទ IgM

b. អង្គបដិបក្ខ មាន សកម្មភាព ក្នុងរយៈពេលវែង

c. កដំណាក់កាល latence មានរយៈពេលខ្លី

d. មាន ការផលិត យ៉ាងខ្លាំង នូវបរិមាណ អង្គបដិបក្ខ ប្រភេទ IgG

58 / 60

marqueur របស់ Lymphocyte T helper

a. CD28

b. CD4

c. CD8

d. CD25

59 / 60

កោសិកាដែលមានសកម្មភាព cytotoxique គឺ:

a. Cellule Natural Killer

b. Les granulocytes

c. Plasmocyte

d. Composants C5-C9 de complément

60 / 60

Au cours de la réaction immunitaire ។ ពពួក macrophages :

a. ផលិត IL-2

b. ផលិត protéine C réactif

c. ផលិត IL-1

d. បំផ្លាញ cellule infectée via activité cytotoxique directe

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Immunologie Générale Et Appliquée Test

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