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ContrΓ΄le QualitΓ© Pharmaceutique Preparation (Pr. Tout Sokhom)

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1) The range of concentration for analytical method validation is normally set between?

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2) Test Dissolution αž‚αžΊαž’αŸ’αžœαžΎαžŠαžΎαž˜αŸ’αž”αžΈ?

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3) La monographie est ?

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4) The ability of an analytical method is how well replicate measurements agree with one another,
usually expressed as a standard deviation is the definition of?

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5) For identification of the unknown sample by spectrophotometry, what is the information we
need from the measurement?

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6) Which one of these is a microbiological property of Drug product (finished product)?

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7) Which statement best describes a standard operating procedure (SOP)?

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8) αžαžΎαž™αžΎαž„αž€αŸ†αžŽαžαŸ‹ αž…αŸ†αž“αž½αž“αž“αžΆαž‘αžΈαž“αž·αž„αž‡αž»αŸ† αž‘αŸ…αž›αžΎαž§αž”αž€αžšαžŽαŸβ€‹ Friability tester αžŠαžΌαž…αž˜αŸ’αžαŸαž…αž˜αž»αž“αž–αŸαž›αž…αžΆαž”αŸ‹αž•αŸ’αžαžΎαž˜αžŠαŸ†αžŽαžΎαžšαž€αžΆαžš?

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9) Which one of these physicochemical tests, is not test of Drug substance (Raw materials)?

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10) In the validation method for assay of paracetamol tablet by spectrophotometer at wavelength
257nm, the solution to be prepared are? Except

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11) Les paramΓ¨tres doivent Γͺtre Γ©crit dans la monographie sont suivent, excepte ?

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12) αž€αŸ’αž“αž»αž„αž€αžšαžŽαžΈαž’αŸ’αž“αž€αž”αžΆαž“αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Disintegration αž…αŸ†αž“αž½αž“ 6 αž‚αŸ’αžšαžΆαž”αŸ‹ αž˜αžΆαž“αŸ‘αž‚αŸ’αžšαžΆαž”αŸ‹αž’αŸ’αž›αžΆαž€αŸ‹αž…αŸαž‰αž–αžΈ Limit acceptable αŸ” αžαžΎαž’αŸ’αž“αž€αžŸαž“αŸ’αž“αž·αžŠαŸ’αž‹αžΆαž“αžŠαžΌαž…αž˜αŸ’αžαŸαž…?

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13) Which one of these is a physicochemical property of Drug product (finished product)?

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14) αž€αŸ’αž“αž»αž„αž€αžšαžŽαžΈαž’αŸ’αž“αž€αž”αžΆαž“αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Uniformity of weight αž…αŸ†αž“αž½αž“αŸ’αŸ αž‚αŸ’αžšαžΆαž”αŸ‹αž˜αžΆαž“αŸ£αž‚αŸ’αžšαžΆαž”αŸ‹αž’αŸ’αž›αžΆαž€αŸ‹αž…αŸαž‰αž–αžΈ Limit αž‘αžΈαŸ‘αŸ” αžαžΎαž’αŸ’αž“αž€αžŸαž“αŸ’αž“αž·αžŠαŸ’αž‹αžΆαž“αžŠαžΌαž…αž˜αŸ’αžαŸαž…?

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15) Which one of these is a physicochemical test of Drug product (finished product)?

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16) Which one of these physicochemical tests, is not test of Drug product (finished product)?

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17) La référentiels de la qualité des matières premières peut trouver dans ?

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18) We prepare the indicator solution of potassium chromate (K2CrO4, MM = 194.19 g/mol) 5%
(W/V) in 100ml of water, we weight mK2CrO4 ?

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19) The ability of an analytical method to demonstrate how closely the result of an experiment
agrees with the expected result is the definition of?

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20) The ability of an analytical method is the lowest amount of analyte in a sample which can be
detected, is the definition of?

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21) The ability of an analytical method is how well replicate measurements agree with one another,
usually expressed as a standard deviation, express under the same operating conditions over a
short interval of time, etc. is the definition of?

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22) The parameters need to be validated for new analytical method development in order to testing
for limit of impurities are?

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23) Test Disintegration αž‚αžΊαž’αŸ’αžœαžΎαžŠαžΎαž˜αŸ’αž”αžΈ?

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24) αžαžΎαž€αžΆαžšαž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Disintegration αžαŸ’αžšαžΌαžœαž’αž“αž»αžœαžαŸ’αžαž“αŸαž”αžΆαž“αž“αŸ…αžŸαžΈαžαž»αžŽαŸ’αž αž—αžΆαž–αž”αŸ‰αž»αž“αŸ’αž˜αžΆαž“?

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25) Which form of drug formulation need to evaluate for dissolution percentage?

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26) αž€αŸ’αž“αž»αž„αž€αžšαžŽαžΈαž™αžΎαž„αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Friability αž–αŸαž›αž§αž”αž€αžšαžŽαŸαžŠαŸ†αžŽαžΎαžšαž€αžΆαžšαž…αž”αŸ‹ αž˜αžΆαž“αžαŸ’αž“αžΆαŸ†αŸ‘αž‚αŸ’αžšαžΆαž”αŸ‹αž”αŸ‚αž€αž‡αžΆαŸ’ αžαžΎαž™αžΎαž„αž•αŸ’αžαž›αŸ‹αž›αž‘αŸ’αž‹αž•αž›αžŠαžΌαž…αž˜αŸ’αžαŸαž…?

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27) Test uniformity of weight, the deviation of individual masses from the average mass less than 80
mg should not exceed the limits given below?

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28) Which one of these is a physicochemical test of Drug substance (Raw materials)?

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29) αžαžΎαž“αŸ…αž–αŸαž›αžŽαžΆαž‘αžΎαž”αž’αŸ’αž“αž€αž’αžΆαž…αžŸαž“αŸ’αž“αž·αžŠαŸ’αž‹αžΆαž“αžαžΆαž±αžŸαžαžŠαŸ‚αž›αž”αžΆαž“αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž αž‡αžΆαž”αŸ‹ Uniformity of weight?

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30) The methodology of calibration of glassware are? Choose incorrect answer.

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31) The requirements of the test disintegration are met if not less than 16 of the 18 dosage units
tested have disintegrated for uncoated tablet?

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32) The calibration based on the direct mass measurement of water delivered by a pipet or
contained in a volumetric flask and conversion to volume with the density, at the specified
temperature is the methodology of?

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33) Which one of these physicochemical tests, is not test of Drug substance (Raw materials)?

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34) αž€αŸ’αž“αž»αž„αž€αžšαžŽαžΈαž’αŸ’αž“αž€αž”αžΆαž“αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αžβ€‹ Uniformity of weight αž…αŸ†αž“αž½αž“αŸ’αŸ αž‚αŸ’αžšαžΆαž”αŸ‹ αž˜αžΆαž“αŸ‘αž‚αŸ’αžšαžΆαž”αŸ‹αž’αŸ’αž›αžΆαž€αŸ‹αž…αŸαž‰αž–αžΈ Limit αž‘αžΈαŸ’αŸ” αžαžΎαž’αŸ’αž“αž€αžŸαž“αŸ’αž“αž·αžŠαŸ’αž‹αžΆαž“αžŠαž½αž…αž˜αŸ’αžαŸαž…?

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35) Why are standard operating procedures important?

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36) In the assay of paracetamol tablet, what are the solutions need to run in spectrophotometer?

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37) When need calibration of glassware? Choose incorrect answer.

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38) Which one of these physicochemical tests, is not test of Drug substance (Raw materials)?

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39) Analytical method can be divided into two main types?

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40) DΓ©finition de la spΓ©cification ?

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41) The parameters need to be validated for new analytical method development in order to
identification of chemical compounds is?

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42) Which one of these is a microbiological property of Drug product (finished product)?

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43) Which of the following is not correct about High pressure liquid chromatography (HPLC)?

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44) Which form of drug formulation has disintegration time?

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45) αžαžΎαž€αžΆαžšαž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Dissolution αžαŸ’αžšαžΌαžœαž’αž“αž»αžœαžαŸ’αžαž“αŸαž”αžΆαž“αž“αŸ…αžŸαžΈαžαž»αžŽαŸ’αž αž—αžΆαž–αž”αŸ‰αž»αž“αŸ’αž˜αžΆαž“?

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46) Which one of these is a physicochemical test of Drug substance (Raw materials)?

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47) Which form of drug formulation has pH in specification?

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48) Which one of these physicochemical tests, is not test of Drug substance (Raw materials)?

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49) What is the Concentration in mol/L of 0.1g NaOH , 250ml?

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50) Which one of these physicochemical tests, is not test of Drug product (finished product)?

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51) Test microbiologique (qualitΓ© microbienne) des produits pharmaceutiques est un test qui ?

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52) αžαžΎαž€αžΆαžšαž€αŸ†αžŽαžαŸ‹ Limit acceptable αž“αŸ…αž€αŸ’αž“αž»αž„ Uniformity of weight αž‚αŸαž€αŸ†αžŽαžαŸ‹αž‘αžΎαž„αžŠαžΌαž…αž˜αŸ’αžαŸαž…αžαŸ’αž›αŸ‡ αž…αŸ†αž–αŸ„αŸ‡αž‘αŸ†αžšαž„αŸ‹αž±αžŸαžαž“αžΈαž˜αž½αž™αŸ—?

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53) The ability of an analytical method to distinguish analyte from everything else that might be in
the sample is the definition of?

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54) The ability of an analytical method to obtain test results which are directly proportional to the
concentration (amount) of analyte in the sample is the definition of?

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55) 36- Test uniformity of weight, the deviation of individual masses from the average mass more
than 250 mg should not exceed the limits given below?

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56) αžŠαžΎαž˜αŸ’αž”αžΈαžœαž·αž—αžΆαž‚αžšαž€αž”αžšαž·αž˜αžΆαžŽαžŸαžΆαžšαž’αžΆαžαž»αžŸαž€αž˜αŸ’αž˜αž±αžŸαž (Dossage/Assay) αžαžΎαž˜αžΆαž“αžœαž·αž’αžΈαžŸαžΆαžŸαŸ’αžšαŸ’αž (Method) αž’αŸ’αžœαžΈαžαŸ’αž›αŸ‡?

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57) What is QC in pharmaceutical industrials?

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58) αž€αŸ’αž“αž»αž„αž€αžšαžŽαžΈαž’αŸ’αž“αž€αž”αžΆαž“αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αžβ€‹ Disintegration αž…αŸ†αž“αž½αž“ 6 αž‚αŸ’αžšαžΆαž”αŸ‹ αž˜αžΆαž“αŸ£αž‚αŸ’αžšαžΆαž”αŸ‹αž’αŸ’αž›αžΆαž€αŸ‹αž…αŸαž‰αž–αžΈ Limit acceptableαŸ” αžαžΎαž’αŸ’αž“αž€αžŸαž“αŸ’αž“αž·αžŠαŸ’αž‹αžΆαž“αžŠαžΌαž…αž˜αŸ’αžαŸαž…?

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59) What is the Concentration in C% (W/V) of 4g NaOH, 100ml?

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60) αžαžΎαž“αŸ…αž–αŸαž›αžŽαžΆαž‘αžΎαž”αž™αžΎαž„αž’αŸ„αž™αž›αž‘αŸ’αž’αž•αž›αž‡αžΆαž”αŸ‹αžαŸαžŸαŸ’αž Friability?

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61) αžαžΎαž±αžŸαžαž”αŸ’αžšαž—αŸαž‘αžŽαžΆαžαŸ’αž›αŸ‡αžαž˜αŸ’αžšαžΌαžœαž±αŸ’αž™αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Uniformity of weight? (αžšαž€αž…αž˜αŸ’αž›αžΎαž™αžαž»αžŸ)

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62) 35- Test uniformity of weight, the deviation of individual masses from the average mass 80 mg to
250 mg should not exceed the limits given below?

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63) The finished products containing active ingredients should comply with ……………….
composition of the marketing authorization.?

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64) Which one is the correct sequence for drug absorption through the oral route?

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65) αžŠαžΎαž˜αŸ’αž”αžΈαžšαž€αž—αžΆαž‚αžšαž™αž“αŸƒαž—αžΆαž–αžŸαž»αž‘αŸ’αž’ (Purity) αžšαž”αžŸαŸ‹αžœαžαŸ’αžαž»αž’αžΆαžαž»αžŠαžΎαž˜ αž™αžΎαž„αžαŸ’αžšαžΌαžœαž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž?

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66) αž“αŸ…αž–αŸαž›αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Disintegration αžαžΎαž’αŸ’αž“αž€αžŸαž„αŸ’αž€αŸαžαž˜αžΎαž›αžšαž”αŸ€αž”αž˜αž·αž… αž‘αžΎαž”αž€αžαŸ‹αž™αž€αž“αžΆαž‘αžΈαž‡αžΆαž›αž‘αŸ’αž’αž•αž›?

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67) The interval between the upper and lower concentration (amounts) of analyte in the sample for
which it has been demonstrated that the analytical procedure has a suitable level of precision,
accuracy and linearity, is the definition of?

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68) La Module 3 du dossier CTD (ou ACTD) est dΓ©crit des informations concernent ?

69 / 82

69) The ability of an analytical method is how well replicate measurements agree with one another,
usually expressed as a standard deviation, express within-laboratories variations: different days,
different analysts, different equipment, etc. is the definition of?

70 / 82

70) αžαžΎαž™αžΎαž„αžαŸ’αžšαžΌαžœαž™αž€αžαŸ’αž“αžΆαŸ†αž”αŸ‰αž»αž“αŸ’αž˜αžΆαž“αž‚αŸ’αžšαžΆαž”αŸ‹αž‘αŸ…αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž Friability? αžŸαžΌαž˜αž”αž‰αŸ’αž‡αžΆαž€αŸ‹

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71) Which one of these is a physicochemical test of Drug product (finished product)?

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72) What is Conformance to specification means?

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73) Which one of these is a physicochemical test of Drug product (finished product)?

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74) In process control (ContrΓ΄le en cours de la fabrication) αž’αŸ’αžœαžΎαžŠαžΎαž˜αŸ’αž”αžΈ?

75 / 82

75) Which one of these physicochemical tests, is not test of Drug substance (Raw materials)?

76 / 82

76) Which one of these is a physicochemical property of Drug substance (raw materials)?

77 / 82

77) The calibration based on a calibrated vessel is used as a reference in the calibration of an
unknown vessel, is sometime used when many glassware items are to be calibrated is the
methodology of?

78 / 82

78) The requirements of the test disintegration are met if not less than 16 of the 18 dosage units
tested have disintegrated for coated tablet?

79 / 82

79) Which one of these physicochemical tests, is not test of Drug product (finished product)?

80 / 82

80) The parameters need to be validated for new analytical method development in order to assay of
chemical compounds are included, except?

81 / 82

81) αžαžΎαž“αŸ…αž–αŸαž›αžŽαžΆαž‘αžΎαž”αž’αŸ’αž“αž€αž’αžΆαž…αžŸαž“αŸ’αž“αž·αžŠαŸ’αž‹αžΆαž“αžαžΆαž±αžŸαžαžŠαŸ‚αž›αž”αžΆαž“αž’αŸ’αžœαžΎαžαŸαžŸαŸ’αž αž’αŸ’αž›αžΆαž€αŸ‹ Uniformity of weight?

82 / 82

82) The ability of an analytical method is the lowest concentration of analyte that can be measured
in the sample matrix at an acceptable level of precision and accuracy, is the definition of?

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