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Immunologie GΓ©nΓ©rale Et AppliquΓ©e Preparation (Dr. Khor Hok Sunn)

 

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1)

An epitope:

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2)

During the maturation of a B lymphocyte, the first immunoglobulin heavy chain synthesized is:

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3)

Graft and tumor rejection are mediated primarily by:

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4)

To which one of the following groups would it be acceptable to give a live attenuated viral vaccine?

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5)

Several of the complement components are:

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6)

In the application Antigen- Antibody reaction, which one is correct?

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7)

In the vaccine response, interleukin (IL-4, IL-5, IL-13) acts to?

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8)

Which antibody is the first to be released into the blood following an infection?

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9)

The type of T-cells that destroy host cells bearing foreign antigen:

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10)

Which of the following is not the function of antibody?

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11)

Antigen-presenting cells that activate helper T cells must express which one of the following on their surfaces?

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12)

The effectiveness is:

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13)

Hemolytic disease of the newborn caused by Rh blood group incompatibility requires maternal antibody to enter the fetal bloodstream. Therefore, the mediator of this disease is:

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14)

The following statements are related to Rhesus D alloimmunization in pregnancy which statement is incorrect?

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15)

What is the immune cell in adaptive immunity?

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16)

A vaccine that activates both cell- mediated and humoral immunity would most likely be :

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17)

The following statements are criteria for a good vaccine but which is incorrect statement?

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18)

Newborns get their antibodies from mother’s milk. This is an example of?

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19)

The purpose of clinical trial of a vaccine is:

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20)

All the following comes under non-specific defence mechanism except

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21)

The adverse effects of vaccines are linked to:

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22)

An antigen is:

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23)

The immunoglobulins transport across placenta mostly:

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24)

The bonds involved in antigen-antibody interactions are

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25)

Natural humoral immune response against a pathogen leads to the production of:

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26)

Which of the following immune cells/molecules are most effective at destroying intracellular pathogens?

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27)

In the application Antigen- Antibody reaction, which one is correct?

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28)

In the application Antigen- Antibody reaction, which one is correct?

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29)

In the immune response to a hapten–protein conjugate, in order to get anti-hapten antibodies, it is essential that:

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30)

The Adverse events following immunization (AEFI) are divided into:

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31)

The cytotoxic T-cells is involved in:

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32)

Immunogen is:

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33)

Adjuvant used in HBV vaccine is:

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34)

Mode of IPV vaccine administration is:

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35)

Injection of immunoglobulin is:

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36)

The class of immunoglobulin present in highest concentration in blood of a human newborn is:

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37)

Which of the following substances will not stimulate an immune response unless they are bound to a larger molecule?

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38)

Small chemical groups on the antigen molecule that can react with antibody

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39)

The Follicular Dendritic Cells (FDCs) is located in:

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40)

Serum which contains antibodies is called:

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41)

What is the mode of administration for PCV-13 vaccine?

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42)

In order to elicit an immune response, a carbohydrate must be which of the following?

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43)

The naive T cells are:

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44)

In the application Antigen- Antibody reaction, which one is not correct?

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45)

The antibody-binding site is formed primarily by:

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46)

The class I MHC molecule appeared to bind with receptor of:

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47)

What is the mode of administration for BCG vaccine?

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48)

The following statements are related to hepatitis B and pregnancy which statement is incorrect?

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49)

Which of the following antibodies would most likely be found in body secretions such as tears, milk, saliva and mucus?

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50)

Infectious material from what illness was used to develop the first vaccine?

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51)

A potential disadvantage of immunological protection using passive transfer of horse globulins is:

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52)

What vaccine should be avoided for the pregnant woman?

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53)

The role of the macrophage during an antibody response is to:

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54)

The following statements are the use of passive immunization included but except one?

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55)

The complement system consists of about:

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56)

Which of the following statement is true

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57)

The efficacy is:

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58)

All are factors influencing in immunogenicity but except:

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59)

The circulation of a two month old breast-fed baby will contain maternal:

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60)

The characteristic of antigen-antibody interactions occur in primary stage:

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61)

To drive antigen for proliferating and differentiating into armed effector T cells, The activated T cells produce :

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62)

All are functions of immunoglobulins but except:

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63)

Adjuvant used in HPV vaccine is:

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64)

Skin is the largest organ in the body and protects us by preventing pathogen entry. This is an example of?

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65)

Which of the following is not an ideal property of a vaccine?

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66)

The main advantage of passive immunization over active immunization is that:

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67)

Successful immunization can be impaired by:

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68)

What vaccine can be used for pregnant women?

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69)

All are therapeutic applications of polyclonal antibodies but except one?

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70)

Which of the following is the site of T cell maturation?

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71)

All are the measure for post rabies exposure prophylaxis, but except one?

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72)

The herd immunity is:

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73)

The classical pathway of complement activation is:

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74)

Which of the following immune cells/ molecules are most effective at destroying intracellular pathogens?

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75)

The technology used for the production of monoclonal antibodies is:

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76)

The classical pathway of complement activation is:

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77)

Primary lymphoid organs include

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78)

Which of the following statement is true regarding vaccination:

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79)

The immune cells that is linked between innate and adaptive immunity are:

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80)

The first line of defense against invading pathogens:

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81)

The complement system involved in chemotaxis are:

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82)

The impact is:

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83)

What is a live attenuated vaccine?

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84)

HBV vaccine and HBIG are given at same time at two different injection sites within:

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85)

An immunoglobulin is a:

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86)

All are 3 main effects of complement but except:

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87)

All are mechanism of action of complement but except:

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88)

In an immune response the type of cell which gets activated earliest is:

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89)

The ideal storage conditions of adjuvanted vaccines in a refrigerator are between:

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90)

Which of the following is a polysaccharide vaccine:

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91)

Which of the following statements are true regarding polio vaccines:

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92)

All are Antigen-Presenting Cells (APCs) but except:

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93)

The class II MHC molecule appeared to bind with receptor of:

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94)

All are examples of names of monoclonal antibodies but except one?

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95)

A primary immune response in an adult human requires approximately how much time to produce detectable antibody levels in the blood?

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96)

What vaccine should not be frozen:

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97)

Often patients are immune to diseases like chicken pox once infecte. This immunity is an example of?

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98)

The immune cells that is linked between innate and adaptive immunity are:

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99)

The class of immunoglobulin present in highest concentration in blood of a human newborn is

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100)

The first recombinant antigen vaccine approved for human use is:

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101)

What is the minimum percentage of children which needs to be vaccinated successfully in order to achieve herd immunity to diphtheria:

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102)

The complement system involved in phagocytic function are:

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103)

Tetanus toxoid is usually given to humans:

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104)

Which of the following immune mechanism is responsible for protecting us from diseases of other species?

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105)

Which category of hypersensitivity best describes hemolytic disease of the newborn caused by Rh incompatibility?

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106)

The inability of very young children to respond to the measles vaccine due to the persistence of maternal antibody is similar in principle to and exploited in which of the following?

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107)

All are important characteristics of innate immunity but except:

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108)

The complement system are synthesized by:

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109)

The following statements are important mechanisms in which immunoglobulin molecules are essential included but except one?

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110)

Antigen presenting cells for vaccine are:

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111)

Vaccination is an example of?

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112)

Which of the following antibodies have a positive effect on babies through breast feeding?

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113)

All are immune cells in innate immune system but except:

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114)

A patient presents with an increased number of lymphocytes in his peripheral blood. Which of the following is an appropriate technique to find out which type of lymphocytes these are?

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115)

The general principle of vaccination was established by:

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116)

In the vaccine response, INF gamma, TNF alpha and IL12 act on?

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117)

Which of the following antibody types forms a pentamer?

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118)

Injection of anti-venom to a patient for snake bite is example of?

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119)

Name the cytokine produced by Th1 cells that are responsible for activating macrophages:

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120)

The characteristic of antigen-antibody interactions occur in second stage:

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121)

All the given vaccines are attenuated or inactivated whole pathogen except:

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122)

The complement system involved in the inflammation are:

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123)

For vaccination against mycobacterial diseases such as tuberculosis, the most important facet of the immune response to be stimulated is:

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124)

What is the mode of administration for anti-measles vaccine?

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125)

The characteristic of antigen-antibody interactions occur in tertiary stage:

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126)

The process of weakening a pathogen is called:

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127)

The antigen-antibody interactions occur in:

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128)

The immunoglobulins participated in complement system formation are:

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129)

An epitope is:

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The immunoglobulins transport across epithelium:

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