Immunologie Générale Et Appliquée Test

0 votes, 0 avg

You will have 60 minutes to complete all the questions. After the timer reaches 60 minutes, the exam will end and be saved automatically. Good luck! *Fingers crossed*

The timer has been reached. The exam has now been terminated and saved.

1 / 60

Which of the following describes where MHC-I is found and not where MHC-II is found ?

a. Macrophages

b. Dendritic cells

c. All nucleated cells

d. B cells

2 / 60

Anaphylatoxins are chemotaxins that stimulate phagocytosis and degranulation. Which complement components is/are mainly involved ?

a. C2 & C4

b. C3

c. C5

d. C3 & C5

3 / 60

Which of the following can activate the alternative complement pathway ?

a. IgG

b. C3b

c. Ciq

d. IgD

4 / 60

In the embryonic human , the primary lymphoid organs are initially in the yolk sac , then in the feta l ____, and finally in the ____.

a. Spleen and thymus; Bone marrow and kidneys

b. Spleen and kidneys; Bone marrow and thymus

c. Kidneys and thymus; Bone marrow and spleen

d. Spleen and liver; Bone marrow and thymus

5 / 60

An immunologic immunoassay situation in which antibody is in excess a s compared to antigen is called:

a. Prozone

b. Postzone

c. Equivalence zone

d. Zone of equivalence

6 / 60

Which of the following is NOT true when comparing p rimary immune response to subsequent (secondary) immune response?

a. Primary response has IgM as the major antibody class

b. Primary response has a high affinity for antigen

c. Secondary response takes 1-3 days

d. Primary response takes 5-10 days

7 / 60

Patients with MHC class II (or class I) antigen deficiency would exhibit which of the following?

a. Human immuno-deficiency virus (HIV) infection

b. Persistent bacterial and viral infections

c. Systemic inflammatory response syndrome (SIRS, sepsis)

d. Acquired immune deficiency syndrome (AIDS)

8 / 60

Which immunoglobulins help initiate the classic complement pathway ?

a. IgM only

b. IgG only

c. IgA and IgD

d. IgG and IgM

9 / 60

Which of the following is an agent (e.g. aluminum salts, oil-based, virosomes) often used to modify or augment the effects of a vaccine by stimulating the immune system to respond to the vaccine more vigorously, and thus providing increased immunity to a particular disease?

a. Antigen

b. Immunogen

c. Adjuvant

d. Stimulant

10 / 60

Which complement component is found in both the classical a nd a lte r n a tive pa thw a ys?

a. C1

b. C3

c. C2

d. Factor B

11 / 60

Which of the following components of the adaptive immune system secretes immunoglobulin (Ig) ?

a. Activated B cell (plasma cell)

b. CD8+ cytotoxic T cell (CTL)

c. CD4+ activated T cell

d. CD4+ T cell and CD8+ T cell

12 / 60

In somatic recombination, the ____ rearranges first. The ____ region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constan t region and a variable region .

a. Heavy chain; Fc

b. Heavy chain; Fab

c. Light chain; Fc

d. Light chain; Fab

13 / 60

The genes encoding which of the following are extensively polymorphic (have multiple alleles or forms of the same gene)?

a. TCRs

b. MHCs

c. BCRs and TCRs

d. BCRs

14 / 60

The ____ T cell-APC interaction is MHC ____-restricted, and the ____ T cell-target cell interaction is MHC ____-restricted.

a. CD4+; Class II; CD8+; Class I

b. CD4+; Class I; CD8+; Class II

c. CD8+; Class II; CD4+; Class I

d. CD8+; Class I; CD4+; Class II

15 / 60

Humoral immunity is mediated by antibodies from ____ and is involved in the elimination of ____ pathogens. Cell mediated immunity is mediated by ____ and is involved in the elimination of ____ pathogens.

a. T lymphocytes; Extracellular; B lymphocytes; Intracellular

b. B lymphocytes; Intracellular; T lymphocytes; Extracellular

c. T lymphocytes; Intracellular; B lymphocytes; Extracellular

d. B lymphocytes; Extracellular; T lymphocytes; Intracellular

16 / 60

The antibody-binding site is formed primarily by

a. The hypervariable regions of H chains.

b. The constant regions of H and L chains.

c. The hypervariable regions of H and L chains.

d. The variable regions of H chains.

17 / 60

Which of the following is NOT true when comparing innate to adaptive immunity?

a. Innate has immunologic memory and adaptive does not

b. Innate responds quickly and Adaptive responds slowly

c. Innate does not show response improvements over time and adaptive does

d. Innate response is non-specific and adaptive is very specific

18 / 60

The membrane attack complex (MAC) uses C3 to activate the final part of the complement pathway. It is important in defense against Neisseria. Which of the following components is/are inserted into the plasma membrane of the target cel l, allowing for free passage of water/solute and thus killing the cell?

a. C8

b. C7-C9

c. C7

d. C5 & C6

19 / 60

Which of the following u ses ultraviolet (UV) light for examining specimens?

a. ELISA (Enzyme-linked immunosorbent assay)

b. FACS (fluorescence-activated cell sorting)

c. Western blotting (immunoblotting)

d. Fluorescent antibody (fluorochromes)

20 / 60

Protestive antibodies against infectious agents are often :

a. Toxoids

b. Neutralizing

c. Autoantibodies

d. Natural killer

21 / 60

Which of the following is NOT tru e of CD4 and CD8 cell markers?

a. There are both surface glycoproteins expressed on T-cells.

b. There are not found associated with immunoglobulin.

c. Both of the maker present on all T-cells.

d. These serve to distinguish different type of T-cells.

22 / 60

In the immune response to a hapten–protein conjugate, in order to get anti-hapten antibodies, it is essential that:

a. The protein be recognized by helper T cells

b. The hapten be recognized by suppressor T cells

c. The protein be recognized by B cells

d. The hapten be recognized by helper T cells

23 / 60

Injection of immunoglobulin is:

a. Artificial type of active immunity

b. Artificial type of passive immunity

c. Natural type of passive immunity

d. Natural type of active immunity

24 / 60

Which of the following substances will not stimulate an immune response unless they are bound to a larger molecule?

a. Hapten

b. Virus

c. Antigen

d. Antibody

25 / 60

Which antibody is the first to be released into the blood following an infection?

a. Ig A

b. Ig D

c. Ig M

d. Ig G

26 / 60

An antigen is:

a. A protein produced by B cells to respond to an immunogen and also reacts with an antigen

b. A substance that induces a specific immune response

c. A chemical that inhibits the growth of micro organisms

d. A substance which reacts with the products of a specific immune response

27 / 60

The following statements are the use of passive immunization included but except one?

a. Exposure to pathogens that can cause death faster

b. Toxin or venom exposure with immediate threat to life

c. Exposure to pathogens that can cause death longer

d. Immune deficiency, especially congenital or acquired B-cell defects

28 / 60

The complement system involved in phagocytic function are:

a. C3a, C4a and C5a

b. C3 and C4

c. C3a and C5a

d. C3b and C5b

29 / 60

Tetanus toxoid is usually given to humans:

a. With complete Freund's adjuvant

b. Absorbed to aluminum hydroxide

c. Without the addition of any other agent

d. Only as a therapeutic agent, not prophylactically

30 / 60

The bonds involved in antigen-antibody interactions are

a. Weak and Strong bonds

b. Strong covalent bonds

c. Weak hydrogen bonds and Vanderwalls forces

d. Strong di-sulphide bonds

31 / 60

Infectious material from what illness was used to develop the first vaccine?

a. Cowpox

b. Polio

c. Plague

d. Diphtheria

32 / 60

An epitope:

a. Is usually composed of a linear sequence of amino acids

b. Requires both antigen-binding arms of the antibody molecule for its recognition

c. Is the area on an antibody which contacts antigen

d. Is the area on an antigen which contacts antibody

33 / 60

All are functions of immunoglobulins but except:

a. Secretion of cytokines

b. Binding to various cell types

c. Antigens bindings

d. Fixation of complement

34 / 60

The following statements are criteria for a good vaccine but which is incorrect statement?

a. Provide durable, long-term protection against disease

b. Achieve immunity with a several number of doses

c. Provide broadest protection against infection

d. Are effective in preventing severity of infectious disease

35 / 60

Which of the following immune cells/molecules are most effective at destroying intracellular pathogens?

a. B cells

b. T helper cells

c. Complement

d. T cytolytic cells

36 / 60

The class of immunoglobulin present in highest concentration in blood of a human newborn is

a. Ig G

b. Ig A

c. Ig D

d. Ig M

37 / 60

The class of immunoglobulin present in highest concentration in blood of a human newborn is:

a. Ig M

b. Ig A

c. Ig D

d. Ig G

38 / 60

Which of the following is the site of T cell maturation?

a. Spleen

b. Thymus

c. Appendix

d. Bone marrow

39 / 60

Small chemical groups on the antigen molecule that can react with antibody

a. Paratope

b. Allotope

c. Epitope

d. Isotope

40 / 60

The class II MHC molecule appeared to bind with receptor of:

a. Plasma cell

b. Suppressor T cell

c. Helper T cell

d. Cytotoxic T cell

41 / 60

Mode of IPV vaccine administration is:

a. Sub-cutaneous or intramuscular (IM)

b. Oral

c. Intravenous (IV)

d. Intra dermal

42 / 60

Name the cytokine produced by Th1 cells that are responsible for activating macrophages:

a. IL-5

b. Interferon

c. IL-4

d. IFN-gamma

43 / 60

The complement system consists of about:

a. Twenty plasma proteins

b. Twenty immunoglobulins

c. Twenty lymphocytes

d. Twenty antigens

44 / 60

The circulation of a two month old breast-fed baby will contain maternal:

a. IgA

b. IgM

c. IgD

d. IgG

45 / 60

All are immune cells in innate immune system but except:

a. Macrophages

b. NK cells

c. Dendritic cells

d. Lymphocytes

46 / 60

The immune cells that is linked between innate and adaptive immunity are:

a. T helper cells

b. NK T-cells

c. T cytotoxic cells

d. Macrophages

47 / 60

The classical pathway of complement activation is:

a. Toxins pathway

b. Lectin pathway

c. Ig A pathway

d. Ig M pathway

48 / 60

The Adverse events following immunization (AEFI) are divided into:

a. 6 categories

b. 5 categories

c. 3 categories

d. 4 categories

49 / 60

In the application Antigen- Antibody reaction, which one is correct?

a. Radioimmunoassay is used to detect antigen or antibodies

b. Agglutination reaction is measuring of concentration of antigen and antibody

c. Precipitation test is identifying blood grouping and cross matching

d. Immunofluorescence is to locate and identify antigen in tissues and clinical materials

50 / 60

Antigen presenting cells for vaccine are:

a. Dendritic cells

b. NK cells

c. Neutrophile

d. Macrophage

51 / 60

The inability of very young children to respond to the measles vaccine due to the persistence of maternal antibody is similar in principle to and exploited in which of the following?

a. Low dose tolerance regimens

b. Tolerance to self antigens

c. Neonatal inability to respond to T-independent antigens

d. Passive immunization as a means of preventing active sensitization (e.g., Rhogam injections)

52 / 60

The immunoglobulins transport across epithelium:

a. Ig A, Ig M

b. Ig A, Ig M and Ig G

c. Ig A and Ig G

d. All immunoglobulins

53 / 60

What vaccine can be used for pregnant women?

a. Rubella vaccine

b. Measle vaccine

c. Tetanus vaccine

d. Varicella vaccine

54 / 60

The general principle of vaccination was established by:

a. Louis Pasteur

b. Joseph Miester

c. dward Jenner

d. Carl Landsteiner

55 / 60

សារធាតុមួយណាដែលបញ្ចេញដោយ lymphocyte T activé

a. histamine

b. protéine C réactif

c. Interferon gamma

d. protéines de compléments

56 / 60

មុខងារ effecteur របស់អង្គបដិបក្ខ ក្នុងការបំផ្លាញកោសិកា cible ប្រព្រិត្តឡើងតាមរយៈ

a. ផ្នែក F(ab)2 របស់អង្គបដិបក្ខ

b. récepteur នៃ compléments

c. ផ្នែក Fc របស់ អង្គបដិបក្ខ

d. កោសិកា phagocyte

57 / 60

Toxines ត្រូវបាន neutralisé ដោយ

a. endonucléase

b. anticorps

c. toxoïds

d. compléments

58 / 60

Cytokine ចំបង ដែលផលិតដោយ lymphocyte Th1 គឺ:

a. Interferon alpha

b. Interleukine-4

c. Interleukine-10

d. Interferon gamma

59 / 60

réaction immunitaire primaire មានភាពខុសគ្នា នឹង ប្រតិកម្ម secondaire ដោយ :

a. អង្គបដិបក្ខ មាន សកម្មភាព ក្នុងរយៈពេលវែង

b. មាន ការផលិត យ៉ាងខ្លាំង នូវបរិមាណ អង្គបដិបក្ខ ប្រភេទ IgG

c. កដំណាក់កាល latence មានរយៈពេលខ្លី

d. មាន ការផលិត យ៉ាងខ្លាំង នូវបរិមាណ អង្គបដិបក្ខ ប្រភេទ IgM

60 / 60

Cytokine ចំបង ដែលផលិតដោយ lymphocyte Th2 គឺ:

a. Interleukine-4

b. Interferon gamma

c. Interleukine-10

d. Interleukine-12

Your score is

The average score is 87%

Any comments?

Immunologie Générale Et Appliquée Test

Any problems/errors or mistakes found while testing, please let us know for modification!

និស្សិតអាចប្រាប់មកកាន់ពួកយើងបានដើម្បីកែកំហុស ឬអំពីបញ្ហាដោយអចេតនាណាមួយដែលកើតមានកំឡុងពេលធ្វើតេស្ត