Immunologie Générale Et Appliquée Test

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1 / 60

The following statements are criteria for a good vaccine but which is incorrect statement?

a. Provide durable, long-term protection against disease

b. Provide broadest protection against infection

c. Are effective in preventing severity of infectious disease

d. Achieve immunity with a several number of doses

2 / 60

Immunogen is:

a. A substance which reacts with the products of a specific immune response

b. A protein produced by B cells to respond to an immunogen and also reacts with an antigen

c. A chemical that inhibits the growth of micro organisms

d. A substance that induces a specific immune response

3 / 60

The complement system involved in phagocytic function are:

a. C3a and C5a

b. C3a, C4a and C5a

c. C3 and C4

d. C3b and C5b

4 / 60

What is the mode of administration for PCV-13 vaccine?

a. Subcutaneous route (SC)

b. Oral route

c. Intramuscular (IM)

d. Intradermal route (ID)

5 / 60

Which of the following immune cells/molecules are most effective at destroying intracellular pathogens?

a. Complement

b. T helper cells

c. B cells

d. T cytolytic cells

6 / 60

The general principle of vaccination was established by:

a. Joseph Miester

b. Carl Landsteiner

c. dward Jenner

d. Louis Pasteur

7 / 60

What vaccine can be used for pregnant women?

a. Varicella vaccine

b. Tetanus vaccine

c. Measle vaccine

d. Rubella vaccine

8 / 60

The immunoglobulins transport across epithelium:

a. Ig A and Ig G

b. All immunoglobulins

c. Ig A, Ig M

d. Ig A, Ig M and Ig G

9 / 60

The immunoglobulins participated in complement system formation are:

a. Ig D and Ig M

b. Ig G and Ig E

c. Ig G and Ig A

d. Ig G and Ig M

10 / 60

In the application Antigen- Antibody reaction, which one is correct?

a. Precipitation test is identifying blood grouping and cross matching

b. Immunofluorescence is to locate and identify antigen in tissues and clinical materials

c. Radioimmunoassay is used to detect antigen or antibodies

d. Agglutination reaction is measuring of concentration of antigen and antibody

11 / 60

All are therapeutic applications of polyclonal antibodies but except one?

a. Laboratory tests

b. Hematologic disorders

c. Skin diseases

d. Neurologic disorders

12 / 60

The immunoglobulins transport across placenta mostly:

a. Ig G4

b. Ig G1

c. Ig G2

d. Ig G3

13 / 60

Successful immunization can be impaired by:

a. Maternal antibody

b. Cloning the vaccine

c. Adjuvants

d. Cytokines

14 / 60

A patient presents with an increased number of lymphocytes in his peripheral blood. Which of the following is an appropriate technique to find out which type of lymphocytes these are?

a. Enzyme-linked immunosorbent assay (ELISA)

b. Radioimmunoassay (RIA)

c. Western blotting

d. Flow cytometric analysis

15 / 60

In order to elicit an immune response, a carbohydrate must be which of the following?

a. Bound to a protein carrier

b. Administered intranasally

c. Bound to a lipid carrier

d. Degraded

16 / 60

Several of the complement components are:

a. Glycolipids

b. Antibodies

c. Enzymes

d. Cytokines

17 / 60

The following statements are related to hepatitis B and pregnancy which statement is incorrect?

a. The infants then receive two additional doses of HBV vaccine at ages 1-2 M & 6-8 M

b. Three possible routes for transmission of HBV: Transplacental, Natal and Horizontal

c. Both active and passive immunizations are used for HBsAg-positive mothers

d. HBV vaccine and HBIG are given at same time to 2 sites in 12-24 h of delivery

18 / 60

Name the cytokine produced by Th1 cells that are responsible for activating macrophages:

a. IFN-gamma

b. IL-5

c. Interferon

d. IL-4

19 / 60

All are immune cells in innate immune system but except:

a. Macrophages

b. NK cells

c. Dendritic cells

d. Lymphocytes

20 / 60

Which of the following statements are true regarding polio vaccines:

a. Salk and Sabin are polio vaccines

b. Sabin is an inactivated polio vaccine

c. Sabin and Salk are inactivated polio vaccines

d. Salk is live attenuated polio vaccine

21 / 60

The class II MHC molecule appeared to bind with receptor of:

a. Suppressor T cell

b. Helper T cell

c. Cytotoxic T cell

d. Plasma cell

22 / 60

Injection of anti-venom to a patient for snake bite is example of?

a. Artificially acquired passive immunity

b. Artificially acquired active immunity

c. Naturally acquired passive immunity

d. Naturally acquired active immunity

23 / 60

In the application Antigen- Antibody reaction, which one is correct?

a. Precipitation test is used to detect antigen or antibodies

b. Radioimmunoassay is identifying blood grouping and cross matching

c. Immunofluorescence is to locate and identify antigen in tissues and clinical materials

d. Agglutination reaction is measuring of concentration of antigen and antibody

24 / 60

The impact is:

a. An estimate of the direct protection in a field study post licensure

b. The direct protection to a vaccinated individual as estimated from clinical trial

c. An indirect effect of vaccination due to reduced disease transmission

d. The population level effect of a vaccination programme

25 / 60

Skin is the largest organ in the body and protects us by preventing pathogen entry. This is an example of?

a. Naturally acquired passive immunity

b. Artificially acquired adaptive immunity

c. Artificially acquired passive immunity

d. Naturally acquired innate immunity

26 / 60

Which antibody is the first to be released into the blood following an infection?

a. Ig G

b. Ig M

c. Ig D

d. Ig A

27 / 60

réaction immunitaire primaire មានភាពខុសគ្នា នឹង ប្រតិកម្ម secondaire ដោយ :

a. មាន ការផលិត យ៉ាងខ្លាំង នូវបរិមាណ អង្គបដិបក្ខ ប្រភេទ IgG

b. កដំណាក់កាល latence មានរយៈពេលខ្លី

c. មាន ការផលិត យ៉ាងខ្លាំង នូវបរិមាណ អង្គបដិបក្ខ ប្រភេទ IgM

d. អង្គបដិបក្ខ មាន សកម្មភាព ក្នុងរយៈពេលវែង

28 / 60

Défensine ជា:

a. lysozymes

b. cytokines

c. chemokines

d. peptide bactéricide

29 / 60

សារធាតុមួយណាដែលបញ្ចេញដោយ lymphocyte T activé

a. protéines de compléments

b. protéine C réactif

c. Interferon gamma

d. histamine

30 / 60

TLR-4 (Toll Like Receptor-4) ជា pattern recognition receptor) ដែលស្គាល់ៈ

a. ARN double brin

b. Peptidoglycan

c. motif CpG

d. lipopolysaccharide

31 / 60

វ៉ាក់សាំង virus vivant atténué est indiqué សំរាប់

a. ស្ដ្រីមានផ្ទៃពោះ

b. អ្នកជំងឺ leucémie

c. អ្នកជំងឺដែលស្ថិតក្រោមការព្យាបាល ដោយ corticoïde ឬ radiothérapie

d. ក្មេង អាយុក្រោម ៨ ឆ្នាំ

32 / 60

CD8 ជា marqueur របស់

a. Cellule NK

b. lymphocyte B

c. lymphocyte T auxilliaire

d. lymphocyte T cytotoxique

33 / 60

The genes encoding which of the following can undergo hypermutation to create receptors that are an even better fit for foreign antigens ?

a. BCRs and TCRs

b. MHC

c. TCRs

d. BCRs

34 / 60

Which of the following best describes cross-reactivity ?

a. When one antibody can bind with multiple antigens

b. When multiple antibodies can bind with one antigen

c. When multiple antibodies can bind with multiple antigens

d. When one antibody can bind with one antigen

35 / 60

The principle difference between type II and type III hypersensitivity reactions is the:

a. Whether the antigen is cellular or soluble

b. Involvement of helper T cells and macrophages

c. Complement-mediated lysis of host cells

d. Isotype of antibody involved

36 / 60

Which of the following best describes the affinity of antibody secreted for effector B cells ?

a. Decreases during response

b. Low

c. High

d. Increases during response

37 / 60

What is the primary response seen in acute-phase responses to infection ?

a. Increased body temperature.

b. Decreased blood pH

c. Decreased metabolic pH

d. Increased heart rate

38 / 60

The zone at which antibody and antigen are at optimal concentration so that they form a large insoluble lattice together is called the:

a. Equivalence zone

b. Postzone

c. Prozone

d. Prezone

39 / 60

All of the following are true about CD8 T cells EXCEPT that they

a. Are cytotoxicity against virus-infected host cells.

b. Respond to antigenic peptides presented by MHC class I molecules.

c. Respond to antigenic peptides presented by MHC class II molecules.

d. Are part of adaptive immunity.

40 / 60

Which transplant method would prevent the rejection of tissue after and organ transplant?

a. Using organs only from pigs or monkeys

b. Using an organ donated by a close relative because the proteins will always be identical to those of the patient

c. Using organs cloned from the cells of the patient

d. Using organs produced by genetic engineering to get rid of all proteins in the donated organs

41 / 60

Activation of a T cell requires ____. Following activation, the T cell proliferates and differentiates into ____, then moves into peripheral tissues and other organs.

a. Recognition of antigen displayed on MHC molecules and a costimulatory signal; Effector cells

b. Recognition of antigen displayed on MHC molecules; Effector cells

c. Recognition of antigen displayed on MHC molecules; Naïve cells

d. Recognition of antigen displayed on MHC molecules and a costimulatory signal; Naïve cells

42 / 60

Which of the following components of the innate immune system involves recognition molecules such as mannan-binding lectin (MBL ) for bacteria with mannose on the surface ?

a. Natural Killer (NK) cells

b. Interferons

c. Complement system

d. Acute phase proteins

43 / 60

Which of the following is NOT t rue regarding interferon ?

a. Interferon prevents infection spreading from cell to cell.

b. Interferon is viral specific, attacking viral proteins

c. Antigen-presenting cells are inactivated.

d. NK cells are activated by interferon and lyse infected cells

44 / 60

How are B-cell and T-cell antigen receptors distributed ?

a. By size

b. By molecular weight

c. By location in the body

d. By activation (clonal)

45 / 60

Which of the following is used to enumerate and/or separate live cells that express an antigen , sorted by applying an electric charge to the stained cells ?

a. Fluorescent antibody (fluorochromes)

b. ELISA (Enzyme-linked immunosorbent assay)

c. FACS (fluorescence-activated cell sorting)

d. Western blotting (immunoblotting)

46 / 60

A serological reaction is set up in which the antigen and antibody are both soluble and form an insoluble complex that is detected macroscopically. What type of assay was described?

a. Precipitation

b. Flocculation

c. Agglutination

d. Neutralization

47 / 60

What types foes of cell is class MHC-I found on ?

a. Macrophage

b. All Nucleated cells

c. B cells

d. Dendritic cells

48 / 60

Which of the following is NOT involved in the antigen-antibody interaction?

a. Hydrogen bonds

b. Peptide bonds

c. Van der Waals forces

d. Hydrophobic interactions

49 / 60

The two types of light chains are:

a. Lambda (λ) and kappa (κ)

b. Sigma (ς) and gamma (γ)

c. Epsilon (ε) and delta (δ)

d. Alpha (  ) and beta (β)

50 / 60

Which complement component is found in both the classical a nd a lte r n a tive pa thw a ys?

a. C1

b. C2

c. C3

d. Factor B

51 / 60

The membrane attack complex (MAC) uses C3 to activate the final part of the complement pathway. It is important in defense against Neisseria. Which of the following components is/are inserted into the plasma membrane of the target cel l, allowing for free passage of water/solute and thus killing the cell?

a. C8

b. C7

c. C7-C9

d. C5 & C6

52 / 60

What is the major function of C-Reactive protein (CRP)?

a. Helps to form clots

b. Binds hemoglobin

c. Acts as an opsonin

d. Causes vasodilation

53 / 60

Which of the following is a messenge r that mediates the connection between the innate and adaptive immune system ?

a. Complement components

b. Cytokines

c. T and B lymphocytes

d. Interferons

54 / 60

Acquired immunity can be characterized by which of the following?

a. Depends on neutrophils and macrophages

b. Immediate response

c. Nonspecific

d. Involves memory

55 / 60

Hemolytic disease of the newborn caused by Rh blood group incompatibility requires maternal antibody to enter the fetal bloodstream. Therefore, the mediator of this disease is

a. IgA antibody.

b. IgG antibody.

c. IgE antibody.

d. IgM antibody.

56 / 60

A serological test that uses red blood cells coated with exogenous antigens such as bacterial polysaccharides as a method to detect patient antibodies against that exogenous antigen is called:

a. Neutralization

b. Hemagglutination

c. Complement fixation

d. Latex agglutination

57 / 60

Which of the following is used extensively to detect antigens in cells or tissue sections , as well as to screen for auto-antibodies to cell or tissue antigens?

a. ELISA (Enzyme-linked immunosorbent assay)

b. Western blotting (immunoblotting)

c. Fluorescent antibody (fluorochromes)

d. FACS (fluorescence-activated cell sorting)

58 / 60

The antibody-binding site is formed primarily by

a. The constant regions of H and L chains.

b. The variable regions of H chains.

c. The hypervariable regions of H and L chains.

d. The hypervariable regions of H chains.

59 / 60

Immunological memory is a feature exhibited by:

a. Cell-mediated immunity

b. Adaptive immunity

c. Humoral immunity

d. Innate immunity

60 / 60

An immune response against grass pollen often involves:

a. Reaction against MHC

b. Persistent infection by the pollen

c. A hypersensitivity reaction

d. Pathogen-associated molecular patterns

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Immunologie Générale Et Appliquée Test

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និស្សិតអាចប្រាប់មកកាន់ពួកយើងបានដើម្បីកែកំហុស ឬអំពីបញ្ហាដោយអចេតនាណាមួយដែលកើតមានកំឡុងពេលធ្វើតេស្ត