/321 64 Immunology Preparation (Pr. Kiet Vannseth) 1 / 321 1) Which of the following is a β structural chain in class I MHC?: a. β2 –microglobin b. α1 c. α2 d. β1 2 / 321 2) The function of Natural Killer cell is: a. Response to antibody b. Response to bacteria infection c. Kill pathogen d. Damaged the target cell membrane 3 / 321 3) The average incubation period of Hepatitis A is?: a. 30 days b. 15 days c. 60 days d. 7 days 4 / 321 4) Killed Whole-Organism is used to prepare vaccines below, EXCEPT?: a. Hepatitis B b. Polio c. Pertussis d. Rabies 5 / 321 5) One principal function of the Class I and Class II major histocompatibility complex is to: a. Transduce the signal to the T-cell interior b. Mediate immunoglobulin class c. Stimulate production of interleukins d. Help T cell for the recognition Antigen 6 / 321 6) The following cells of immune system cam make IgE: a. Eosinophils b. Mast cells c. Monocytes d. Mast cells and Eosinophils 7 / 321 7) In the alternative pathway of the complement system, the factors below are useful to stabilise the generation of C3 convertase : a. Factor F b. C3-BP c. C1-INH d. Factor P 8 / 321 8) The following cells are cells mediated immunity in adaptive immune response?: a. B cells b. Tc cells c. T cells d. All answers 9 / 321 9) Which of the following hepatitis viruses is RNA virus?: a. Hepatitis A virus b. Hepatitis E virus c. Hepatitis G virus d. Hepatitis B virus 10 / 321 10) B and T cells are produced by stem cells located in:?: a. Bone marrow b. Circulatery system c. Liver d. Spleen 11 / 321 11) Immunity acquired after an infection is?: a. Innate immunity b. Passive immunity c. Response immunity d. Active immunity 12 / 321 12) The following answer is the best marker for Tc cells?: a. CD3 b. CD8 c. CD21 d. CD4 13 / 321 13) Light chains are: a. Have only a constant region b. Specific for each class of antibody c. Reactive with antigen d. Not specific for each class of antibody 14 / 321 14) The following answers is receptor for complement on immunoglobulins: a. Fab region b. Fc region c. Hinge region d. Heavy chain 15 / 321 15) The immunoglobulin(s) that have long hinge region are/is: a. IgG3 b. IgG4 c. IgG2 d. IgG1 16 / 321 16) The following diseases can be prevented by vaccination?: a. Hepatitis C and E b. Hepatitis D and C c. Hepatitis B and C d. Hepatitis A and B 17 / 321 17) Which of the following bacteriocidal mechanisms is oxygen dependant?: a. Lactoferrin b. NADPH oxidation c. Defensins d. Hydrolytic enzymes 18 / 321 18) All of the following are true with respect to IgM antibodies, EXCEPT : a. They are glycoproteins b. They fix complement c. They mediate allergic reaction d. They occur on the surface of lymphocytes 19 / 321 19) The C5 convertase of Classic and Lectin pathway is: a. C4b2a4b b. C3bBb3b c. C4b2a3b d. C4b2b3a 20 / 321 20) How many receptors for antigen on the surface of B lymphocyte: a. 2 b. 4 c. 10 d. 1 21 / 321 21) The followings statement are TRUE for Target cell lysis and destruction,EXCEPT : a. Perforin released from antigen-specific cytotoxic T-cells b. Cytotoxic T-cells recognizing specific epitopes on the target cell surface c. Complement binding to IgE antibodies which have bound to epitopes on the cell surface d. Complement binding to IgG and IgM which have bound to epitopes on the target cell 22 / 321 22) Which immunoglobulin is used to test for blood group: a. IgE b. IgA c. IgM d. IgG 23 / 321 23) The major histocompatibility complex proteins function to: a. Degrade T4 and T8 polypeptides b. Bind antigen for presentation to T-cells c. Bind antibody for lymphokine production d. Bind complement for cell lysis 24 / 321 24) Which of the following technic is the best method to detect early infection of hepatitis?: a. RIA b. PCR c. Agglutination d. ELISA 25 / 321 25) Skin is a________ barrier: a. Physiological b. Inflammatory c. Anatomical d. Phagocytic 26 / 321 26) Clinical abnormalities of the Immune system can result from the following statement, EXCEPT: a. Deficiency diseases b. Abnormal lymphocyte proliferation c. HIV Infection d. T cells proliferation 27 / 321 27) What’s a specific term for a bacterial or other foreign protein that initiates antibody production by the body?: a. MHC II molecule b. Peptide c. Complement d. Antigen 28 / 321 28) Identity the phagocytic cells from the following combinations: a. Macrophage and neutrophil b. Eosinophil and neutrophil c. Macrophage and eosinophil d. Lymphocyte and eosinophil 29 / 321 29) The following vaccines is used after exposure?: a. Varicella b. TB c. Hypogammaglobulinemia d. Tetanus 30 / 321 30) Which cell is directly secreted immunoglobulin: a. Plasma cell b. B lymphocyte c. Macrophage d. T lymphocyte 31 / 321 31) What is the term used to describe white blood cells migrating toward bacteria? : a. Phagocytosis b. Zeiosis c. Chemotaxis d. Phototaxis 32 / 321 32) The region of immunoglobulin(s) can be flexible: a. Fc region b. Fab region c. Heavy chain d. Hinge region 33 / 321 33) Which immunoglobulin is the principal one that is unkown function: a. IgA b. IgD c. IgG d. IgM 34 / 321 34) The following answer is specific for antigen: a. Fc region b. Fab region c. Heavy chain d. Hinge region 35 / 321 35) In the alternative pathway of the complement system, the factors below are useful to prevent the generation of C3 convertase : a. Factor F b. C3-BP c. Factor P d. C1-INH 36 / 321 36) Which nonspecific defense cells specialize in attacking cancer cells and virus-infected cells?: a. NK cells b. TH cells c. B cells d. Macrophages 37 / 321 37) B cells recognised antigen presented by APC?: a. Self – antigen b. T-independent antigen c. Nonself – antigen d. T-dependent antigen 38 / 321 38) Which of the following is antiviral: a. Protein b. Interferon c. Lysozyme d. Hormone 39 / 321 39) Which of the following DOES NOT play a role in antigen presentation: a. MHC class II molecules b. Complement c. MHC class III molecules d. MHC class I molecules 40 / 321 40) Which of the following is NOT a structural chain in class I MHC?: a. α1 b. β1 c. β2 –microglobin d. α2 41 / 321 41) Papain cleaves what region of immunoglobulin?: a. Hinge region b. Light chain c. Heavy chain and Light chain d. Heavy chain 42 / 321 42) T- independent antigen presented to the following lymphocyte?: a. Tc cells b. TH1 cell c. B cells d. TH cells 43 / 321 43) T cells secreted cytokine to activate cells in blood vessel, This phenomen is called: a. All answers b. Paracrine c. Endocrine d. Autocine 44 / 321 44) Individuals make up over C4a would be expected to have: a. Anaphylaxia b. Bacteria c. Diabetis d. Liver disease 45 / 321 45) The following statements are true for Antibodies, EXCEPT: a. Made of heavy and light chains b. Non immunogen c. Composed of variable and constant regions d. They have hypervariable region 46 / 321 46) The variable regions in the heavy chains participate in: a. Cytokine receptor b. Antigen receptor c. Complement receptor d. Cellular receptor 47 / 321 47) The following tests show that patient got chronic infection of HCV?: a. Anti-HCV positive b. ALT elevated c. ALT elevated and Anti-HCV positive d. IgM positive 48 / 321 48) All of the following are true about antibodies, EXCEPT: a. They are glycoproteins. b. They are polypeptide c. They occur on the surface of B-lymphocyte d. They fix complement. 49 / 321 49) These organ is primary lymphoid organ of human?: a. Tonsil b. Lymph node c. Thymus d. Spleen 50 / 321 50) Which of these cell types can play a primary role in attacking and killing cancer cells?: a. Mast cell b. Cytotoxic c. T cell d. Platelet 51 / 321 51) Regulatory T cells (Treg cells), formerly known as ?: a. CD4+ T reg b. Adaptive T reg c. Suppressor T cells d. Natural T reg 52 / 321 52) The answer below is/are artificial active immunization?: a. Killed organisms b. Killed organisms and Attenuated organisms c. Exposure to the infections d. Attenuated organisms 53 / 321 53) Which cells secreted most cytokine in innate immune: a. Plasma cell b. T lymphocyte c. B lymphocyte d. Macrophage 54 / 321 54) Class of immunoglobulins occurs : a. Immunizations, going from IgM to IgG b. Causes the histamine release c. Mediates immunoglobulin class switching d. Binds complement 55 / 321 55) The following statement is for MHC Class I: a. Used to kill by cytotoxic T-cells b. Recognized by the CD8 protein c. Not able to carry an antigen fragment d. Participated in helper function 56 / 321 56) Superantigens presented to T cells by : a. Monocyte b. Mast cell c. B cell d. APC 57 / 321 57) The following statement are for Class I MHC proteins, EXCEPT: a. Participate in T helper function b. Able to carry an antigen fragment c. Recognized by the CD8 protein d. Killed target cells by Tc cells 58 / 321 58) The two types of lymphocytes are ?: a. Platelet and Erythrocyte b. T and B cells c. Platelet and B cells d. Erythrocyte and T cells 59 / 321 59) The following statements are true for Class II MHC molecules, EXCEPT : a. Able to carry an antigen fragment b. Presented antigen to Tc cells c. Recognized by the CD4 d. Used to participate in Th function 60 / 321 60) In the complement system, the classic pathway initiates by the complement : a. C1qrs b. MBL c. C5 d. C4 61 / 321 61) These blood cells have memory after pathogens infection, EXCEPT? TH cells?: a. Tc cells b. B cells c. Macrophages 62 / 321 62) In acute infection of Hepatitis B, the typical serologic course are: a. HBsAb b. HBsAg c. HBcAb d. HBcAg 63 / 321 63) The first immunoglobulin secreted by B cells to make up memory cells is?: a. IgD b. IgG c. IgA d. IgM 64 / 321 64) The disease below can cause allergic reaction: a. Thalassemia b. Cancer c. Asthma d. Hepatitis 65 / 321 65) The following statements are true for Antibodies a. Are made from alpha and beta chains b. Contain cytoplasmic region c. Have variable region d. Are carbohydrates 66 / 321 66) The function of MHC class II is: a. Unable to carry antigen fragment b. Participated in the presentation of Ag c. Recognized by the CD8 d. Recognized by CD4 67 / 321 67) In chronic infection of hepatitis B, the antibody persists in the whole life is?: a. HBsAg b. HBcAg c. HBcAb d. HBsAb 68 / 321 68) The following statements are true for Class I MHC molecules, EXCEPT : a. Tc cells kill an infected cells b. Participated in Th function c. On the APC cells membrane d. Recognized by the CD8 69 / 321 69) Molecule binding to their receptors at high affinity : a. Cytokines b. Antigen c. Antibody d. All answer 70 / 321 70) Which type of cell destroys body cells that cause by infection?: a. Cytotoxic T cells b. Plasma B cells c. Memory T cells d. Memory B cells 71 / 321 71) The natural passive immunity are characterized by?: a. Immunoglobulins b. Placental transfert c. Kill vaccin Immune cell 72 / 321 72) The following viral hepatitis is enteric hepatitis?: a. Heepatitis C b. Hepatitis D c. Hepatitis A d. Hepatitis B 73 / 321 73) One principal function of complement is not true: a. Phagocytize antigens b. Activate perforins c. Mediate the release of histamine d. Lyse target cells 74 / 321 74) The J-chain of immunoglobulin is : a. Present in IgG b. Made by T cells c. Present in IgM d. Made only by epithelial cells 75 / 321 75) The following vaccines are Live Attenuated Vaccines, EXCEPT?: a. Varicella b. Polio c. Hepatitis A d. Tetanus 76 / 321 76) The Complement that gives Anaphylotoxin much potent is: a. C5a b. C4a c. C3a d. C2b 77 / 321 77) Which of the following statements about HBV is NOT correct?: a. Can replicate b. Hepato carcinoma c. Parenteral route d. RNA virus 78 / 321 78) All of the following are true, EXCEPT : a. An antigenic determinant is a paratope b. An epitope is a fragment of a macromolecule c. The variable regions contain the antigen recognition site d. The class of an immunoglobulin is determined by its heavy chain 79 / 321 79) The chronic HCV infection develop hepatocellular carcinoma in the rate of?: a. 20% b. 50% c. 10% d. 5% 80 / 321 80) The type of an immunoglobulin is determined by: a. The carbohydrate b. The light chain c. The heavy chain d. The variable region 81 / 321 81) Which properties do the T-cell receptor and the antibody share in common: a. Both have constant regions b. Both are able to fix complement c. Both are polypeptide chains d. Both recognize antigen fragments 82 / 321 82) Which of the followings are NOT TRUE regarding an immune response: a. The T8 serves an auxiliary role with MHC class I proteins in cytotoxic reactions b. Lymphokines are produced by T-cells in response to antigen presentation by antibody c. The T4 serves an auxiliary role with MHC class II proteins in helper cell reactions d. The principal function of the T3 complex is signal transduction to the cell's interior 83 / 321 83) The following cells of immune system cam make inflammation: a. Mast cells b. Basophils c. Monocytes d. Mast cells and Basophils 84 / 321 84) The following activities are belong to the B-cells : a. Antibodies response to antigens b. Receptor antigen monovalent c. Differentiate into plasma cells d. Act as antigen-processing cells 85 / 321 85) The following statement are for Target cell lysis and destruction, EXCEPT: a. Complement binding to IgG and IgM which have bound to epitopes on the target cell b. Perforin released from antigen-specific cytotoxic T-cells c. Complement binding to IgE which have bound to epitopes on the cell surface d. Cytotoxic T-cells recognizing specific epitopes on the target cell surface 86 / 321 86) The component of immune system that can cause fever is : a. T lymphocytes b. Complement c. Macrophage d. Immunoglobulin 87 / 321 87) Organ transplantation of human from one place to another is called: a. ISO-graft b. Autograft c. Allo-graft d. Xeno-graft 88 / 321 88) The disease below can cause by autoimmune: a. Hepatitis b. Thalassemia c. Cancer d. SLE 89 / 321 89) The following vaccines is not used in United State?: a. Polio b. Tuberculsis c. Hepatitis A d. Varicella 90 / 321 90) All of the following are true about antibodies, EXCEPT: a. They fix complement. b. They are glycoproteins. c. They occur on the surface of B-lymphocyte d. They are a single amino acid sequence 91 / 321 91) The following viral hepatitis are chronic hepatitis, EXCEPT?: a. Hepatitis B b. Heepatitis C c. Hepatitis D d. Hepatitis A 92 / 321 92) The following vaccines is Microbial Fragment Vaccines?: a. Clostridium tetani b. Polio c. Varicella d. Hepatitis A 93 / 321 93) The rabic vaccin is used to?: a. Prevent rabie infection b. Prevent tetanus infection c. Cure tetanus infection d. Cure rabie infection 94 / 321 94) Which immunoglobulin is the principal one found in secretions such as mucus : a. IgG b. IgM c. IgA d. IgD 95 / 321 95) The following disease is the cancer of lymphocyte?: a. Lymphocytopenia b. Non-Hodgkin lymphoma c. Mycobacterium d. Listeria 96 / 321 96) Which of the following is NOT a major feature (characteristic) of the adaptive immunesystem?: a. Diversity b. Improvement c. Specificity d. Memory 97 / 321 97) All of the following are function of IgG, EXCEPT : a. Opsonize bacteries b. Activate complement c. Cross placenta d. Primary response to antigen 98 / 321 98) Immediate hypersensitivity reactions are below, EXCEPT: a. The consequence of antigen-antibody reactions b. Phagocytosis c. If the antigen is an allergen d. Result from histamine release 99 / 321 99) The function of major histocompatibility complex for antigen in the cytosol is: a. Presentation antigen to Tc-cells b. Presentation antigen to Th-cells c. Bind complement for cell lysis d. Transport protein 100 / 321 100) Which of the following organ is primarily infected by Hepatitis viruses?: a. Intestines b. Liver c. Spleen d. Lung 101 / 321 101) Class II MHC are : a. Recognized by the CD4 protein b. Used to participate in cytotoxic function c. Not able to carry an antigen fragment d. Used to kill by cytotoxic T-cells 102 / 321 102) The following statements are true for IgE, EXCEPT: a. They bind to mast cells b. They produce allergic reaction c. Can cross the placental barrier d. The least immunoglobulin in the plasma 103 / 321 103) The variable regions in the light chains participate in: a. Fc receptor binding. b. Epitope binding. c. Interaction of the Fab with cytokines. d. Affinity of the complement receptors. 104 / 321 104) How many serotypes of HCV in the world?: a. 6 b. 4 c. 2 d. Many 105 / 321 105) Antigen-antibody reactions can result in the following: a. Virus neutralization b. All answers c. Complement fixation d. Killed antigen 106 / 321 106) The following answer is NOT true for interleukins?: a. Regulation between cells b. Produced by antigen c. Produced by T cells d. They are not in stock 107 / 321 107) The TH cells produced cytokines to response the viral infection?: a. IL-2 b. Tumor necrose factor c. Chimokine d. Interferon 108 / 321 108) The Immunoglobulins are secreted by: a. B-cells b. Plasma cells c. T-cells d. Macrophages 109 / 321 109) The screening test for HBV infection is?: a. HBcAg b. HBsAg c. HBcAb d. HBsAb 110 / 321 110) The first immunoglobulin response to the viral hepatitis A infection is?: a. IgE IgM b. IgG c. IgA 111 / 321 111) HBV infection is characterized by the present of ?: a. All answers b. HBsAg c. HBeAg d. HBcAg 112 / 321 112) The Biological Effects of C3b is : a. Susceptibility to bacterial infections b. Lack of opsonisation c. Phagocyte activation d. Anaphylaxia 113 / 321 113) Which of the following are true statements: a. IgD provides immunization b. IgE lyses allergen c. IgM and IgG can fix complement d. IgA can fix complement 114 / 321 114) Clinical abnormalities of the Immune system can result from the activities below: a. T cell secrete cytokine b. Plasma cells secrete antibody c. Neutrophils kill bacteria d. Abnormal lymphocyte proliferation 115 / 321 115) All of the following are a part of innate immune respond, EXCEPT : a. Natural Killer cells b. Pathways of complement activation c. Macrophage secrete cytokines d. T cells secrete antibody 116 / 321 116) All of the following statements are true for the diagnosis of HBV infection, EXCEPT?: a. Bilirubin b. Liver enzyme c. Serological HBV d. Glucose test 117 / 321 117) Which cell is Granulocyte: a. Monocyte b. Basophil c. Macrophage d. Lymphocyte 118 / 321 118) Which of the following causes AIDS ?: a. TMV b. Retrovirus c. Fungus d. Bacteria 119 / 321 119) T-cell receptors or antibodies react with antigens: a. Because both are made by lymphocytes b. Cause histamine release c. Because both 'have light chain and heavy chain polypeptides d. Because they have specific receptors for antigen 120 / 321 120) Each of the following statement is a characteristic of antibodies, EXCEPT: a. They have specific receptor for antigen b. They have four glycoprotein chains c. They are phagocytes d. They contain variable region 121 / 321 121) Which antigen is direct presented to B cell?: a. Self- antigen b. T- Independent antigen c. T- dependent antigen d. Non self- antigen 122 / 321 122) Individuals unable to make the C4b would be expected to have frequent infections of the : a. Diabetis b. Thalassemia c. Bacteria d. Liver disease 123 / 321 123) The basic monomeric Immunoglobulin unit is: a. Four polypeptide chains and One of five major classes b. One of five major classes c. Synthesized by a T-cell d. Four polypeptide chains 124 / 321 124) IgE produce by : a. B-cells b. Plasma cells c. T-cells d. Mast cells 125 / 321 125) The following statements are true for Immunoglobins, EXCEPT: a. Are antibodies b. Possess both variable and constant regions c. Five major classes IgM, IgG, IgA, IgD, IgE d. All have receptors for complement 126 / 321 126) The major function of major histocompatibility complex for antigen intracellular is: a. Presentation antigen to Tc-cells b. Degrade Th and Tc c. Bind complement for cell lysis d. Presentation antigen to Th-cells 127 / 321 127) The following bonds is responsible for linking of antibody to its chains: a. Van der Waals forces b. Hydrogen bonds c. Hydrophobic forces d. Disulfide bonds 128 / 321 128) The function of Class III MHC proteins are : a. Transport complement protein b. Lyse antigen c. Recognized antigen by CD4 d. Recognized antigen by CD8 129 / 321 129) Which part of antibody lack of constant domain: a. CL b. VL c. CL and CH d. CH 130 / 321 130) All of the following are true of antigen, EXCEPT: a. They contain antigenic determinants. b. They contain epitopes. c. They will react with antibodies. d. They contain paratopes 131 / 321 131) The C5 convertase of Alternative pathway is: a. C4b2b3a b. C4b2a3b c. C3bBb3b d. C4b2a4b 132 / 321 132) Each of the following is a characteristic of antibodies, EXCEPT : a. They contain carbohydrates b. They are proteins with variable and constant regions c. They are only secreted by T-cells d. They combine specifically with antigen 133 / 321 133) All of the following are true, EXCEPT: a. IgG antibody is pentavalent b. The variable contain the antigen recognition site c. An epitope is a portion of an antigen d. IgM antibody is pentamer 134 / 321 134) Histamine is secreted by: a. Red blood cells b. Mast cells c. Epithelial cell d. White blood cells 135 / 321 135) Clinical abnormalities of the Immune system can result from the activities below, EXCEPT: a. Abnormal lymphocyte proliferation b. Bacterial infection c. HIV Infection d. T cell secrete cytokine 136 / 321 136) The following immunoglobulin can opsonize antigen during acute phase infection?: a. IgM b. IgE IgA c. IgG 137 / 321 137) Which of the following statements about leukocyte function is false?: a. Eosinophils deliver toxic granules to kill parasites. They are also involved in allergic reactions. b. Neutrophils engulf damaged cells and pathogens by phagocytosis. c. Macrophages are phagocytic cells that are involved in the adaptive response. d. Leukocytes are involved in the immune response. 138 / 321 138) The first screening test to detect HBV infection is?: a. HBsAb b. HBcAb c. HBsAg d. HBcAg 139 / 321 139) Lymphocytes that develop immunocompetence in the thymus are?: a. NK cells b. B cells c. LGL's d. T cells 140 / 321 140) In chronic infection of hepatitis B, the antigen persists in the whole life are?: a. HBcAg b. HBeAg c. HBsAg d. All answers 141 / 321 141) Which of the following statements about leukocyte function is false?: a. Eosinophils release histamine . b. Neutrophils phagocytose pathogens . c. Eosinophils kill parasites d. Leukocytes are cells of the immune response. 142 / 321 142) The Cytotoxic T cells kill the cells/molecules below: a. Infected cells b. Bacteria c. Intracellular antigen d. Extracellular antigen 143 / 321 143) The tetanus vaccine is prepare from ?: a. Virulence antigen b. Toxin antigen c. Killed antigen d. Inactivated antigen 144 / 321 144) Which of the following immunoglobulin can across placenta with the highest concentration?: a. IgG3 b. IgG4 c. IgG2 d. IgG1 145 / 321 145) In the complement system, the lytic pathway initiated by the complement : a. C1qrs b. C5 c. MBL d. C4 146 / 321 146) The T-cell receptor is: a. Bivalent b. Secreted by the T-cell c. Recognized antigen fragments d. Recognized antibody 147 / 321 147) The following answer is Super antigen: a. Mycose b. HIV c. Virus d. Staphylococus toxin 148 / 321 148) Which lymphocyte response to HBV infectin?: a. Th b. Tc c. B cells d. Macrophage 149 / 321 149) The following immunoglobulin(s) become monomer when they attaché antigen : a. IgM b. IgG c. IgA d. IgE 150 / 321 150) The following cells are proliferated from myloid progenitor : a. Dendritic cells b. B cells c. Lymphocytes d. TH1 151 / 321 151) Name the process a cell such as a neutrophil or a macrophage uses to ingest (eat) its prey.: a. Chemotaxis b. Botulism c. Phagocytosis d. Halitosis 152 / 321 152) The following statements are true, EXCEPT: a. IgM and IgG can fix complement b. IgA is a secretory immunoglobulin c. IgD provides passive immunity d. IgE mediates hypersensitivity 153 / 321 153) The following organs do not affect by hepatitis virus, EXCEPT: a. Heart b. Kidneys c. Liver d. Brain 154 / 321 154) The cancer of T cells are called?: a. All answers b. Hodgkin lymphoma c. Non-Hodgkin lymphoma d. Extranodal T cell lymphoma 155 / 321 155) Tumor Necrose Factor (TNF) produce by: a. Macrophage and Tc b. Neutrophil c. Tc d. Macrophage 156 / 321 156) These cytokines secreted by T helper cell?: a. TNF-α b. Chimokine c. IL-2 d. Interferon 157 / 321 157) The drug to cure post exposure of HBV is?: a. IgA b. IgE c. IgG d. IgM 158 / 321 158) Which of the following is NOT true of interleukins: a. They are able to bind antigen with a high level of specificity b. They are cytokines which can be produced by various cells of the immune system. c. They are hormones which allow one cell to communicate with another cell. d. They are in need of receptors on the target cell in order to mediate their effects. 159 / 321 159) The tests below show that patient has an chronic infection of HBV?: a. HBsAg positive b. HBcAb positive c. All answers d. HBsAb negative 160 / 321 160) The following answers are function of B cell, EXCEPT?: a. Antibody secretion b. APC c. Memory B cells d. Complement cascade 161 / 321 161) The following immunoglobulin is used to produe vaccine?: a. IgG4 b. IgG c. IgM d. IgA 162 / 321 162) When hepatitis vaccin start to use since year?: a. 199000% b. 1960 c. 2002 d. 1985 163 / 321 163) The incubation period of HBV in the body is?: a. 30-60 days b. 45-180 days c. 60-100 days d. 30-90 days 164 / 321 164) The light chains of antibodies are distinguished by: a. The J-chains that bind to them b. Their variable region domains c. Their constant specific region d. Kappa or lambda types 165 / 321 165) The classical pathway of the complement is initiated by: a. Factor B b. MBL c. C1qrs d. C3 166 / 321 166) The following statements are not true for Immunoglobins a. Five major classes of immunoglobulin b. Possess both variable and constant regions c. All have receptors for complement d. They have Fab 167 / 321 167) Which type of antibody is MOST effective in activating complement?: a. IgG3 b. IgM c. IgG1 d. IgG2 168 / 321 168) What distinguishes helper T-cells from cytotoxic T-cells : a. Cytotoxic cells recognize antigen complexed with MHC class I molecules and. Helper cells recognize antigen complexed with MHC class II molecules b. Helper cells recognize antigen complexed with MHC class II molecules c. Cytotoxic cells recognize antigen complexed with MHC class I molecules d. Helper cells recognize antigen complexed with MHC class I molecules 169 / 321 169) Which cells are proliferated from myeloid progenitor: a. B cells b. Dendritic cells c. Lymphocytes d. TH1 170 / 321 170) The fragment of Antigen is called: a. Antigenic determinant b. Immunoglbulin c. Hapten d. Immunogen 171 / 321 171) The following activity is indicated T cell cytotoxic: a. Epitope presented to CD4 b. MHC-II restricted c. MHC-I restricted d. B cell activation 172 / 321 172) The much potent anaphylotoxin of the complement is: a. C5a b. C4a c. C3a d. C2b 173 / 321 173) The following statement are for adaptive immune response, EXCEPT : a. Can be facilitated through macrophage cells b. Can be facilitated by antibodies c. Is mediated by the humoral and cellular of the immune d. Can be facilitated through T-cells 174 / 321 174) Which of the following components of the innate immune system involves the release ofhistamine?: a. Eosinophil b. Macrophage c. Tissue mast cell d. Neutrophil 175 / 321 175) Biological effect of Complement C5a is: a. Opsonisation b. Neutrophil activation c. Phagocytosis d. Inflammation 176 / 321 176) Biological effect of Complement C3a is: a. Edema b. Phagocytosis c. Opsonisation d. Anaphylaxis 177 / 321 177) The followings statement are TRUE, EXCEPT: a. MHC I presented on all cells of the immune b. MHC II carrying antigen presented to Tc c. MHC II bind antigen and recognized by the Th d. MHC I bind antigen and recognized by the Tc 178 / 321 178) T cells secreted cytokine to activate T cells neighbering, This phenomen is called?: a. Endocrine b. None about c. Paracrine d. Autocrine 179 / 321 179) The following characcteristic is common for T and b cells?: a. have constant regions b. able to fix complement c. Polypeptide chains d. Recognize antigen 180 / 321 180) Biological properties of C5a are: a. All answers b. Attract and activate PMN c. Anaphylactic much potent d. Chimotactic activity 181 / 321 181) The following immunoglobulin has extra domain and long tail : a. IgM b. IgE c. IgA d. IgG 182 / 321 182) Where is the variable region of Immunoglobulin?: a. VL b. CH2 c. CL d. CH3 183 / 321 183) The pathway of the complement that can lyse bacteria is: a. Classical pathway b. Lytic pathway c. Alternative pathway d. Lectin pathway 184 / 321 184) The most infection chronic and acute HBV is in?: a. Adult b. Male c. Children d. Female 185 / 321 185) The class of an immunoglobulin is determined by: a. The antigen b. The light chain c. Class I and II MHC d. The heavy chain 186 / 321 186) Complements are chemically: a. Glycoproteins b. Proteins c. Glycogens d. Lipoproteins 187 / 321 187) The following statement are MOST closely related to each, EXCEPT: a. Antibody b. Epitope c. Antigen d. Allergen 188 / 321 188) The following statements are true for the antigenic determinant : a. Is the combining site of an antibody b. Is paratope c. Small part of the antigen d. Is paratope and Small part of the antigen 189 / 321 189) The vaccine prepared from living and inactivated microbe is considered as?: a. Antibody b. Atenuated vaccin c. A toxoid d. Denatured 190 / 321 190) The J-chain is : a. Facilitates secretion of pentameric lgM b. For immunoglobulin multimer formation c. For immunoglobulin multimer formation and Facilitates secretion of pentameric lgM d. Made only by epithelial cells 191 / 321 191) How many receptors for antigen on the surface of T lymphocyte: a. 4 b. 2 c. 1 d. 10 192 / 321 192) The primairy response of antibody to the HBV is?: a. IgM b. IgG c. IgA d. IgE 193 / 321 193) Which of the following antibody fragments consists of a dimer of the heavy-chain constantregion but lacks the CH1 domains?: a. F(ab)’2 b. F(ab) c. Fab d. Fc 194 / 321 194) The tests below show that patient is already vaccinated against HBV?: a. HBcAb negative b. HBsAb positive c. All answers d. HBsAg negative 195 / 321 195) The functional activity of the T-cell: a. Is related with CD4 or CD8 associated polypeptides b. All answers c. Can be mediated through cytokines d. Occurs after recognition of an epitope 196 / 321 196) How many percentage of chronic HBV infection can lead to Cirrhosis?: a. 15% b. 10% c. 25% d. 50% 197 / 321 197) To stabilise the C3 convertase of the alternative pathway, the factors below are useful : a. Factor F b. Factor P c. C1-INH d. C3-BP 198 / 321 198) The receptor BCR for an antigen on the membrane of B cell is?: a. Monovalent b. Bivalent c. Trivalent d. None about 199 / 321 199) The function of LGL cell is: a. Response to bacteria infection b. Respose to tumor cells c. Response to antibody d. Kill pathogen 200 / 321 200) Which kind of cells worked in innate immune system and response to the tumor cells?: a. Macropages b. T cells c. NK cells d. B cells 201 / 321 201) The function of major histocompatibility complex is: a. Bind epitope for presentation to T-cells b. Bind complement for cell lysis c. Bind antibody for cytokine secretion d. Degrade T4 and T8 polypeptides 202 / 321 202) An antigenic determinant is: a. Recognized by macrophage b. A fragment of Antigen c. Molecule of antigen d. Recognized by a epitope 203 / 321 203) The percentage of TH cell among lymphocytes is?: a. 23% b. 7% c. 46% d. 19% 204 / 321 204) The following statements are true for Antibodies, EXCEPT : a. Extra domain for IgM b. Receptors for antigens are monovalent c. Fc receptor for complement d. Made of heavy and light chains 205 / 321 205) These cells can be infected by Mycobacterium tuberculosis: a. Eosinophil b. Macrophage c. Neutrophil d. Lymphocyte 206 / 321 206) Which of the following hepatitis viruses is RNA virus?: a. Hepatitis D virus b. Hepatitis B virus c. Hepatitis C virus d. Hepatitis A virus 207 / 321 207) All of the following are true, EXCEPT: a. IgG antibody is bivalent b. An epitope is a portion of an antigen c. IgM antibody is pentavalent d. The variable contain the antigen recognition site 208 / 321 208) Which of the following are mechanisms for neutrophil phagocytosis: a. Azerophilic granules and defensins b. Azerophilic granules c. defensins d. Hydrolytic enzymes 209 / 321 209) Microbial Fragment Vaccines is used to prevent the diseases below, EXCEPT: a. Polio b. Neisseria meningitides c. Hepatitis B virus d. Haemophilus influenzae B 210 / 321 210) Light chains are : a. Specific for each class of antibody b. Complement fixation c. Have only a constant region d. Reactive with antigen 211 / 321 211) Which of the following represent immune system dysfunctions: a. T cells proliferation b. Mast cells release histamine c. Facilitated by antibodies d. Severe immunodeficiency 212 / 321 212) Which of the immune cells/molecules are effective to neutralise and opsonse extracellularpathogens?: a. Complement b. B cells c. T cells d. Antibodies 213 / 321 213) All of the following are the type RNA virus, EXCEPT?: a. Hepatitis E b. Hepatitis A c. Hepatitis B d. Hepatitis C 214 / 321 214) Class II MHC proteins are: a. Used to kill cytotoxic T-cells b. Recognized by the CD8 protein c. Participate in T helper function d. Not able to carry an epitope 215 / 321 215) The function of cytokines are : a. Regulation the immune cells b. Bind to MHC class I c. Production of complement d. Specifically recognize antigens 216 / 321 216) The T3 complex of the T-cell receptor: a. Causes the histamine b. Binds complement c. Mediates Immunoglobulin class switching d. To transduce a signal to the cell's interior 217 / 321 217) Platelets can produce by those organs: a. Liver b. Spleen c. Bone marrow d. Thymus