Immunology Test

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Immunology Test

1 / 60

The following answer is the best marker for Tc cells?:

a. CD3

b. CD21

c. CD4

d. CD8

2 / 60

The Immunoglobulins are secreted by:

a. Macrophages

b. T-cells

c. Plasma cells

d. B-cells

3 / 60

Which of the following statement is related to IgG physiology in humans?:

a. Opsonisation through FcR on macrophages occurs with IgG2 and IgG4.

b. It is confined to the bloodstream, giving the host protection against blood-borne pathogens.

c. It can be arranged to resemble a pentamer of five distinct immunoglobulin molecules.

d. IgG crosses the placental barrier, and thereby provides passive immunity to the fetus.

4 / 60

All of the following are true with respect to IgG antibodies, EXCEPT:

a. They are glycoproteins

b. They fix complement

c. They mediate allergic reaction

d. They occur on the surface of B lymphocytes

5 / 60

Clinical abnormalities of the Immune system can result from the activities below, EXCEPT:

a. Bacterial infection

b. Abnormal lymphocyte proliferation

c. T cell secrete cytokine

d. HIV Infection

6 / 60

The following cells are proliferated from myloid progenitor :

a. TH1

b. Dendritic cells

c. Lymphocytes

d. B cells

7 / 60

Which properties do the T-cell receptor and the antibody share in common:

a. Both recognize antigen fragments

b. Both are able to fix complement

c. Both have constant regions

d. Both are polypeptide chains

8 / 60

All of the following are the type RNA virus, EXCEPT?:

a. Hepatitis A

b. Hepatitis C

c. Hepatitis B

d. Hepatitis E

9 / 60

The variable regions in the light chains participate in:

a. Affinity of the complement receptors.

b. Fc receptor binding.

c. Epitope binding.

d. Interaction of the Fab with cytokines.

10 / 60

The following statement are for Target cell lysis and destruction, EXCEPT:

a. Cytotoxic T-cells recognizing specific epitopes on the target cell surface

b. Perforin released from antigen-specific cytotoxic T-cells

c. Complement binding to IgE which have bound to epitopes on the cell surface

d. Complement binding to IgG and IgM which have bound to epitopes on the target cell

11 / 60

The disease below can cause allergic reaction:

a. Asthma

b. Hepatitis

c. Thalassemia

d. Cancer

12 / 60

Identity the phagocytic cells that have Toll like Receptor on their membrane:

a. Eosinophil

b. Basophil

c. Macrophage

d. Neutrophil

13 / 60

Class II MHC are :

a. Recognized by the CD4 protein

b. Not able to carry an antigen fragment

c. Used to participate in cytotoxic function

d. Used to kill by cytotoxic T-cells

14 / 60

The first immunoglobulin response to the viral hepatitis A infection is?:

a. IgG

b. IgA

c. IgE IgM

15 / 60

All of the following are true of antigen, EXCEPT:

a. They contain antigenic determinants.

b. They will react with antibodies.

c. They contain paratopes

d. They contain epitopes.

16 / 60

Individuals make up over C4a would be expected to have:

a. Liver disease

b. Anaphylaxia

c. Diabetis

d. Bacteria

17 / 60

In the complement system, the lytic pathway initiated by the complement :

a. C5

b. C1qrs

c. C4

d. MBL

18 / 60

In chronic infection of hepatitis B, the antigen persists in the whole life are?:

a. All answers

b. HBsAg

c. HBeAg

d. HBcAg

19 / 60

The much potent anaphylotoxin of the complement is:

a. C5a

b. C2b

c. C4a

d. C3a

20 / 60

Which immunoglobulin is the principal one found in secretions such as mucus :

a. IgD

b. IgG

c. IgA

d. IgM

21 / 60

Which of the following require the Thymus?:

a. B cellsmaturation

b. B cel apoptosis

c. T cells rogenitor

d. T cells maturation

22 / 60

The major histocompatibility complex proteins function to:

a. Bind antibody for lymphokine production

b. Bind antigen for presentation to T-cells

c. Degrade T4 and T8 polypeptides

d. Bind complement for cell lysis

23 / 60

The followings statement are TRUE, EXCEPT :

a. MHC Class II bind antigen and are recognized by the T-cell receptor and the CD4

b. MHC Class II carrying antigen presented to cytotoxic T cells

c. MHC Class 1 bind antigen fragments and are recognized by the Tc-cell receptor

d. MHC Class I generally occur on all cells of the immune system

24 / 60

The following organs do not affect by hepatitis virus, EXCEPT:

a. Liver

b. Kidneys

c. Heart

d. Brain

25 / 60

The classical pathway of the complement is initiated by:

a. MBL

b. Factor B

c. C1qrs

d. C3

26 / 60

All of these tests show that patient has been infected with HBV, EXCEPT?:

a. HBcAb positive

b. HBsAb positive

c. HBcAg positive

d. HBsAg negative

27 / 60

The hapten carrier conjugate can activate B cells to secrete antibody :

a. Immunoglobulin-Epitope

b. Antigenic determinant

c. Immunoglobulin

d. Antigen

28 / 60

Which cells are proliferated from myeloid progenitor:

a. Lymphocytes

b. B cells

c. Dendritic cells

d. TH1

29 / 60

Name the process a cell such as a neutrophil or a macrophage uses to ingest (eat) its prey.:

a. Chemotaxis

b. Halitosis

c. Phagocytosis

d. Botulism

30 / 60

The following vaccines is not used in United State?:

a. Varicella

b. Hepatitis A

c. Polio

d. Tuberculsis

31 / 60

The following statements are true for Class III MHC molecules, EXCEPT :

a. On the APC cells membrane

b. Tc cells kill an infected cells

c. Recognized by the CD8

d. Transport protein

32 / 60

The screening test for HBV infection is?:

a. HBcAg

b. HBsAg

c. HBcAb

d. HBsAb

33 / 60

The incubation period of HBV in the body is?:

a. 60-100 days

b. 45-180 days

c. 30-90 days

d. 30-60 days

34 / 60

Light chains are :

a. Reactive with antigen

b. Complement fixation

c. Specific for each class of antibody

d. Have only a constant region

35 / 60

Variable regions of immunoglobulin are:

a. Specific recognition of antigen

b. C-terminal of heavy chains

c. N-terminal of heavy chains

d. Able to fix complement

36 / 60

Which of the following binds to an Fc receptor on mast cells and basophils?:

a. IgM

b. IgG

c. IgA

d. IgE

37 / 60

In acute infection of Hepatitis B, the typical serologic course are:

a. HBcAb

b. HBsAb

c. HBcAg

d. HBsAg

38 / 60

The C5 convertase of Alternative pathway is:

a. C4b2a3b

b. C3bBb3b

c. C4b2b3a

d. C4b2a4b

39 / 60

An antigenic determinant is:

a. Molecule of antigen

b. Recognized by macrophage

c. A fragment of Antigen

d. Recognized by a epitope

40 / 60

Variable domains are:

a. Specific recognition of antigen

b. Transported IgG across the placenta

c. Needed to bind complement

d. Located at the N-terminal of heavy chains

41 / 60

The variable regions in the heavy chains participate in:

a. Cellular receptor

b. Complement receptor

c. Antigen receptor

d. Cytokine receptor

42 / 60

Which of the following bacteriocidal mechanisms is oxygen dependant?:

a. Defensins

b. NADPH oxidation

c. Lactoferrin

d. Hydrolytic enzymes

43 / 60

The first immunoglobulin secreted by B cells to make up memory cells is?:

a. IgA

b. IgD

c. IgM

d. IgG

44 / 60

The following answer is specific for antigen:

a. Heavy chain

b. Fab region

c. Fc region

d. Hinge region

45 / 60

In the alternative pathway of the complement system, the factors below are useful to stabilise the generation of C3 convertase :

a. Factor P

b. Factor F

c. C1-INH

d. C3-BP

46 / 60

Which type of cell destroys body cells that cause by infection?:

a. Memory T cells

b. Memory B cells

c. Cytotoxic T cells

d. Plasma B cells

47 / 60

Which of the following is a β structural chain in class I MHC?:

a. α1

b. β1

c. β2 –microglobin

d. α2

48 / 60

B and T cells are produced by stem cells located in:?:

a. Spleen

b. Circulatery system

c. Liver

d. Bone marrow

49 / 60

The vaccine prepared from living and inactivated microbe is considered as?:

a. A toxoid

b. Atenuated vaccin

c. Antibody

d. Denatured

50 / 60

Class II MHC proteins are :

a. Recognized by CD4 and Used to participate in helper function

b. Recognized by CD8

c. Recognized by CD4

d. Used to participate in helper function

51 / 60

The following answers are function of B cell, EXCEPT?:

a. Complement cascade

b. Memory B cells

c. APC

d. Antibody secretion

52 / 60

The following tests show that patient got chronic infection of HCV?:

a. ALT elevated

b. IgM positive

c. ALT elevated and Anti-HCV positive

d. Anti-HCV positive

53 / 60

How many receptors for antigen on the surface of T lymphocyte:

a. 10

b. 2

c. 1

d. 4

54 / 60

Which cell is T helper:

a. CD14

b. CD4

c. CD8

d. CD15

55 / 60

Which of the following represent immune system dysfunctions:

a. Facilitated by antibodies

b. Mast cells release histamine

c. T cells proliferation

d. Severe immunodeficiency

56 / 60

All of the following are true with respect to IgM antibodies, EXCEPT :

a. They are glycoproteins

b. They fix complement

c. They occur on the surface of lymphocytes

d. They mediate allergic reaction

57 / 60

Intracellular pathogen is presented to the Tc by:

a. Lymphocytes

b. MHC I

c. TH

d. MHC II

58 / 60

The T-cell receptor is:

a. Secreted by the T-cell

b. Recognized antibody

c. Recognized antigen fragments

d. Bivalent

59 / 60

Microbial Fragment Vaccines is used to prevent the diseases below, EXCEPT:

a. Neisseria meningitides

b. Polio

c. Hepatitis B virus

d. Haemophilus influenzae B

60 / 60

Which of the following immunoglobulin is first synthesized in an immune system to response
an pathogen?:

a. IgG

b. IgM

c. IgE

d. IgA

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