Immunology Test

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Immunology Test

1 / 60

The C5 convertase of Classic and Lectin pathway is:

a. C3bBb3b

b. C4b2a3b

c. C4b2a4b

d. C4b2b3a

2 / 60

T cells secreted cytokine to activate T cells neighbering, This phenomen is called?:

a. Autocrine

b. None about

c. Endocrine

d. Paracrine

3 / 60

The function of antibody produced by B cells are?:

a. All answers

b. Neutralisation

c. Complement fixation

d. Opsonisation

4 / 60

Which of the following statements about leukocyte function is false?:

a. Neutrophils engulf damaged cells and pathogens by phagocytosis.

b. Macrophages are phagocytic cells that are involved in the adaptive response.

c. Leukocytes are involved in the immune response.

d. Eosinophils deliver toxic granules to kill parasites. They are also involved in allergic reactions.

5 / 60

Which of the following statement is related to IgG physiology in humans?:

a. It is confined to the bloodstream, giving the host protection against blood-borne pathogens.

b. Opsonisation through FcR on macrophages occurs with IgG2 and IgG4.

c. It can be arranged to resemble a pentamer of five distinct immunoglobulin molecules.

d. IgG crosses the placental barrier, and thereby provides passive immunity to the fetus.

6 / 60

The following answer is the function of IgG, EXCEPT :

a. Activate complement

b. Opsonize bacteries

c. Primary response to antigen

d. Cross placenta

7 / 60

The classical pathway of the complement is initiated by:

a. C3

b. C1qrs

c. MBL

d. Factor B

8 / 60

The following statements are true for Immunoglobins, EXCEPT:

a. All have receptors for complement

b. Are antibodies

c. Possess both variable and constant regions

d. Five major classes IgM, IgG, IgA, IgD, IgE

9 / 60

The function of MHC class II is:

a. Presentation Ag to Th cell

b. Unable to carry antigen fragment

c. Recognized by CD4

d. Recognized by the CD8

10 / 60

Which of the following immune cells are effective to destroying intracellular pathogens:

a. T helper cells

b. T cytolytic cells

c. B cells

d. Antibodies

11 / 60

The following disease is the cancer of lymphocyte?:

a. Non-Hodgkin lymphoma

b. Mycobacterium

c. Lymphocytopenia

d. Listeria

12 / 60

The following statements are true for Antibodies, EXCEPT:

a. Non immunogen

b. Made of heavy and light chains

c. Composed of variable and constant regions

d. They have hypervariable region

13 / 60

All of the following are true about antibodies, EXCEPT:

a. They are a single amino acid sequence

b. They are glycoproteins.

c. They fix complement.

d. They occur on the surface of B-lymphocyte

14 / 60

The following vaccines is Microbial Fragment Vaccines?:

a. Clostridium tetani

b. Varicella

c. Polio

d. Hepatitis A

15 / 60

The following answers is receptor for complement on immunoglobulins:

a. Fab region

b. Hinge region

c. Heavy chain

d. Fc region

16 / 60

Which cells secreted most cytokine in innate immune:

a. Macrophage

b. Plasma cell

c. B lymphocyte

d. T lymphocyte

17 / 60

An antigenic determinant is:

a. A fragment of Antigen

b. Molecule of antigen

c. Recognized by macrophage

d. Recognized by a epitope

18 / 60

The hapten carrier conjugate can activate B cells to secrete antibody :

a. Antigenic determinant

b. Immunoglobulin

c. Antigen

d. Immunoglobulin-Epitope

19 / 60

The region of immunoglobulin term: Binds to various cellular receptors and to complement:

a. Fab region

b. Heavy chain

c. Fc region

d. Light chain

20 / 60

Clinical abnormalities of the Immune system can result from the activities below:

a. T cell secrete cytokine

b. Neutrophils kill bacteria

c. Abnormal lymphocyte proliferation

d. Plasma cells secrete antibody

21 / 60

Graft between identical twins is called:

a. Allograft

b. Xeno-graft

c. Auto graft

d. Iso graft

22 / 60

Which cell is Granulocyte:

a. Monocyte

b. Basophil

c. Macrophage

d. Lymphocyte

23 / 60

Which properties do the T-cell receptor and the antibody share in common:

a. Both are able to fix complement

b. Both recognize antigen fragments

c. Both are polypeptide chains

d. Both have constant regions

24 / 60

Individuals make up over C4a would be expected to have:

a. Bacteria

b. Anaphylaxia

c. Liver disease

d. Diabetis

25 / 60

The first immunoglobulin response to the viral hepatitis A infection is?:

a. IgE IgM

b. IgA

c. IgG

26 / 60

The drug to cure post exposure of HBV is?:

a. IgA

b. IgM

c. IgE

d. IgG

27 / 60

The following statements are true for Antibodies, EXCEPT :

a. Fc receptor for complement

b. Receptors for antigens are monovalent

c. Made of heavy and light chains

d. Extra domain for IgM

28 / 60

In chronic infection of hepatitis B, the antibody persists in the whole life is?:

a. HBcAg

b. HBcAb

c. HBsAg

d. HBsAb

29 / 60

Which of the followings are TRUE regarding an Immune response :

a. The function of the T3 complex is signal to the cell's interior after recognition the antigen

b. The T4 serves an auxiliary role with MHC class I in helper cell reactions

c. The T4 secrete antibody

d. The T8 serves an auxiliary role with MHC class II in cytotoxic reactions

30 / 60

Class II MHC are :

a. Used to kill by cytotoxic T-cells

b. Used to participate in cytotoxic function

c. Not able to carry an antigen fragment

d. Recognized by the CD4 protein

31 / 60

Identity the phagocytic cells from the following combinations:

a. Macrophage and eosinophil

b. Lymphocyte and eosinophil

c. Macrophage and neutrophil

d. Eosinophil and neutrophil

32 / 60

Superantigens presented to T cells by :

a. APC

b. Monocyte

c. Mast cell

d. B cell

33 / 60

The CD marker of B cells are?:

a. CD3 and CD8

b. CD16 and CD56

c. CD3 and CD54

d. CD19 and CD21

34 / 60

One principal function of complement is not true:

a. Mediate the release of histamine

b. Phagocytize antigens

c. Activate perforins

d. Lyse target cells

35 / 60

The receptor BCR for an antigen on the membrane of B cell is?:

a. Monovalent

b. Trivalent

c. Bivalent

d. None about

36 / 60

IgE produce by :

a. Mast cells

b. T-cells

c. B-cells

d. Plasma cells

37 / 60

The following immunoglobulin has extra domain and long tail :

a. IgG

b. IgM

c. IgA

d. IgE

38 / 60

Tumor Necrose Factor (TNF) produce by:

a. Neutrophil

b. Macrophage

c. Tc

d. Macrophage and Tc

39 / 60

The following answer is the best marker for Tc cells?:

a. CD3

b. CD21

c. CD8

d. CD4

40 / 60

B cells that produce large amounts of antibody are called?:

a. Plasma cells

b. Neutrophils

c. Memory B cells

d. T cells

41 / 60

What distinguishes helper T-cells from cytotoxic T-cells:

a. Th recognize antigen with MHC II

b. Tc recognize antigen with MHC I

c. Th recognize antigen with MHC I

d. Tc recognize antigen with MHC I and Th recognize antigen with MHC II

42 / 60

Which among the following is anti-bacterial ?:

a. Lysozyme

b. Protein

c. Hormone

d. Interferon

43 / 60

The following statements are true for IgE, EXCEPT:

a. The least immunoglobulin in the plasma

b. They produce allergic reaction

c. They bind to mast cells

d. Can cross the placental barrier

44 / 60

The average incubation period of Hepatitis A is?:

a. 15 days

b. 60 days

c. 7 days

d. 30 days

45 / 60

Which organ does hepatitis affect?:

a. Brain

b. Liver

c. Kidneys

d. Heart

46 / 60

The function of Class III MHC proteins are :

a. Lyse antigen

b. Transport complement protein

c. Recognized antigen by CD8

d. Recognized antigen by CD4

47 / 60

All of the following are true with respect to IgG antibodies, EXCEPT:

a. They occur on the surface of B lymphocytes

b. They fix complement

c. They mediate allergic reaction

d. They are glycoproteins

48 / 60

Biological effect of Complement C2b is:

a. Edema

b. Opsonisation

c. Anaphylaxis

d. Phagocytosis

49 / 60

The immunoglobulin class which is the second abundant in the normal adult is:

a. IgD

b. IgE

c. IgA

d. IgG

50 / 60

The TH cells produced cytokines to response the viral infection?:

a. IL-2

b. Chimokine

c. Interferon

d. Tumor necrose factor

51 / 60

The following statements are not true for Immunoglobins

a. They have Fab

b. All have receptors for complement

c. Possess both variable and constant regions

d. Five major classes of immunoglobulin

52 / 60

The following statement are for Target cell lysis and destruction, EXCEPT:

a. Cytotoxic T-cells recognizing specific epitopes on the target cell surface

b. Complement binding to IgG and IgM which have bound to epitopes on the target cell

c. Perforin released from antigen-specific cytotoxic T-cells

d. Complement binding to IgE which have bound to epitopes on the cell surface

53 / 60

The Live Attenuated Vaccines are used for the diseases below?:

a. Hepatitis A

b. Varicella zoster

c. All answers

d. Measles

54 / 60

Which of the following is NOT a structural chain in class II MHC?:

a. β 1

b. α3

c. α1

d. α2

55 / 60

The Complement that produce anaphylactic much more potent is:

a. C4a

b. C2b

c. C3a

d. C5a

56 / 60

Pepsin cleaves what region of immunoglobulin?:

a. Heavy chain and Light chain

b. Hinge region

c. Heavy chain

d. Light chain

57 / 60

The following answers are true for IgM antibodies, EXCEPT:

a. Anti infectious

b. Fix complement

c. Cause of allergy

d. Pentametric form

58 / 60

The following statement is the basic monomeric immunoglobulin unit, EXCEPT:

a. Same protein type for all antibody classes

b. The receptor is TCR

c. Composed of glycoproptein chains

d. Able to associate with J- chain to form multimers

59 / 60

The class of an immunoglobulin is determined by:

a. Class I and II MHC

b. The heavy chain

c. The light chain

d. The antigen

60 / 60

The first sign of infection is the characteristic appearance of ?:

a. HBcAb

b. HBsAb

c. HBeAg

d. HBsAg

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