Pharmacologie Preparation (Pr. BC Youttiroung)

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1 / 65

1) Which of the following drugs, inhibits mycobacterial arabinosyl transferases?

a. . Pyrizinamide

b. . Isoniazid

c. . Rifampin

d. . Ethambutol

e. . Streptomycin

2 / 65

2) What is the Mechanism of action of Rifampicin against Mycobacterium leprae?

a. . Inhibits bacterial DNA-dependent RNA synthesis

b. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. . Inhibits mycobacterial arabinosyltransferases

d. . Inhibition of neutrophil and eosinophil myeloperoxidase

e. . Inhibition of dihydropteroate synthase

3 / 65

3) Dose of Rifampicin recommended in multibacillary leprosy in adult is 600 mg

a. . Twice weekly

b. . Once in a month

c. . Once in a week

d. . Once daily

e. . Twice monthly

4 / 65

4) What is the recommended standard treatment duration for leprosy?

a. . 12 or 18 months depending on the operational or clinical classification of the disease

b. . 6 or 8 months depending on the operational or clinical classification of the disease

c. . 6 or 12 months depending on the operational or clinical classification of the disease

d. . 6 months for children and 12 months for adults

e. . 1 or 2 months depending on the operational or clinical classification of the disease

5 / 65

5) The primary reason for the use of drug combinations in the treatment of tuberculosis is to:

a. . Enhance activity against metabolically inactive mycobacteria.

b. . Provide prophylaxis against other bacterial infections.

c. . Reduce the incidence of adverse effects.

d. . Ensure patient compliance with the drug regimen.

e. . Delay or prevent the emergence of resistance.

6 / 65

6) 4. What is the Mechanism of action Rifampicin against TB?

a. . Inhibits synthesis of mycolic acids.

b. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

d. . Inhibits RNA synthesis.

e. . Inhibits mycobacterial arabinosyltransferases.

7 / 65

7) What is the most common adverse reactions of Isoniazid? Choose one best answer.

a. Harmless orange color to urine, sweats, tears, and contact lenses.

b. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. Flu-like syndrome and thrombocytopenia

d. The risk of peripheral neuropathy

e. Ototoxic and Nephrotoxic.

8 / 65

8) Which statement is true about pharmacokinetic of Dapsone?

a. . Half-life may be 2 months.

b. . It is slowly released from the deposits.

c. . Major portion of the drug is excreted in feces.

d. . Cross the placenta, and is found in human breast milk

e. . Excretion into bile and urine

9 / 65

9) A patient taking Anti-leprosy treatment, then he has “Erythema nodosum leprosum”. Which one of the following medicine can cause this adverse reaction?

a. . Minocycline

b. . Dapsone

c. . Clarithromycin

d. . Clofazimine

e. . Rifampicin

10 / 65

10) Which statement is the adverse reaction of Clofazimine?

a. . Ichthyosis and dryness

b. . Hemolysis, particularly if they have G6PD deficiency

c. . Gastrointestinal intolerance, fever, pruritus.

d. . Methemoglobinemia is common, but usually is not a problem clinically

e. . Erythema nodosumleprosum

11 / 65

11) WHO regime for paucibacillary leprosy (PB) in adult is:

a. 50mg Dapsone daily + 450mg Rifampicn monthly

b. 100mg Dapsone daily + 600mg Rifampicin monthly

c. 100mg Dapsone + 600mg Rifampcin + 300mg Clofazimine daily

d. 100mg Dapsone daily + 600mg Rifampicn daily

e. 300mg Clofazimine daily + 300mg Rifampcin daily

12 / 65

12) Skin pigmentation and icthyosis like side effects are seen in patient who received:

a. . Dapsone

b. . Rifampcin

c. . Clofazimine

d. . Steroid

e. . Thalidomide

13 / 65

13) What is the Mechanism of Action of Isoniazid against M tuberculosis? Choose one best answer.

a. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

b. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. Inhibits synthesis of mycolic acids.

d. Inhibits RNA synthesis.

e. Inhibits mycobacterial arabinosyltransferases.

14 / 65

14) What is the common adverse reactions of Rifampicin?

a. . Hemolysis, particularly if they have G6PD deficiency

b. . Skin discoloration ranging from red-brown to nearly black

c. . Hyperuricemia may provoke acute gouty arthritis

d. . Erythema nodosumleprosum

e. . Flu-like syndrome and thrombocytopenia

15 / 65

15) Isoniazid may cause peripheral neuropathy and anaemia as its side effects because

a. It is toxic to nerves and to red blood cells.

b. It is a type of hypersensitivity reaction.

c. It interferes with pyridoxine metabolism and induces its deficiency.

d. It prevents absorption of iron and ascorbic acid.

16 / 65

16) What is the most common toxicity of streptomycin?

a. . Ototoxic and Nephrotoxic.

b. . Immunologic Reactions, Hepatitis and Peripheral neuropathy.

c. . Rashes, thrombocytopenia, and nephritis.

d. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

e. . Hyperuricemia may provoke acute gouty arthritis.

17 / 65

17) A young female patient using an oral contraceptive is to be treated for pulmonary tuberculosis. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes:

a. . Isoniazid

b. . Ethambutol

c. . Pyrazinamide

d. . Rifampicin

e. . Streptomycin

18 / 65

18) What is the most common adverse reactions of PZA ?

a. . Harmless orange color to urine, sweats, tears, and contact lenses.

b. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. . Hyperuricemia may provoke acute gouty arthritis.

d. . Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

e. . Ototoxic and Nephrotoxic.

19 / 65

19) Which statement is true about pharmacokinetic of Rifampicin?

a. . It is slowly released from the deposits.

b. . Major portion of the drug is excreted in feces.

c. . Skin heavily infected with M leprae may contain more drug

d. . Half-life may be 2 months.

e. . Excreted in the feces, small amount in the urine

20 / 65

20) A patient taking Anti-leprosy treatment, then he has “hemolytic anemia”. Which one of the following medicine can cause this adverse reaction?

a. . Dapsone

b. . Clofazimine

c. . Rifampicin

d. . Clarithromycin

e. . Minocycline

21 / 65

21) What is the recommended standard treatment duration for leprosy?

a. 6 or 8 months depending on the operational or clinical classification of the disease

b. 1 or 2 months depending on the operational or clinical classification of the disease

c. 6 months for children and 12 months for adults

d. 12 or 18 months depending on the operational or clinical classification of the disease

e. 6 or 12 months depending on the operational or clinical classification of the disease

22 / 65

22) What is the Mechanism of action Ethambutol against TB? Choose one best answer.

a. Inhibits RNA synthesis.

b. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

c. Inhibits mycobacterial arabinosyltransferases.

d. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

e. Inhibits synthesis of mycolic acids.

23 / 65

23) What is the Mechanism of action Rifampicin against TB? Choose one best answer.

a. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

b. Inhibits mycobacterial arabinosyltransferases.

c. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

d. Inhibits RNA synthesis.

e. Inhibits synthesis of mycolic acids.

24 / 65

24) Which statement is the adverse reaction of Clofazimine?

a. . Erythema nodosumleprosum

b. . Methemoglobinemia is common, but usually is not a problem clinically

c. . Skin discoloration ranging from pink to brownish-black

d. . Gastrointestinal intolerance, fever, pruritus.

e. . Hemolysis, particularly if they have G6PD deficiency

25 / 65

25) Which statement is the adverse reaction of Clofazimine? Choose one best answer.

a. Skin discoloration ranging from pink to brownish-black.

b. Hemolysis, particularly if they have G6PD deficiency.

c. Gastrointestinal intolerance, fever, pruritus.

d. Erythema nodosumleprosum often develops.

e. Methemoglobinemia is common, but usually is not a problem clinically.

26 / 65

26) Dose of rifampicin recommended in multibacillary leprosy in adult is 600 mg

a. Once daily

b. Once in a week

c. Twice weekly

d. Once in a month

e. Twice monthly

27 / 65

27) What is the most common adverse reactions of Rifampicin?

a. . Methemoglobinemia is common

b. . Harmless orange color to urine, sweats, tears, and contact lenses

c. . Gastrointestinal intolerance occurs occasionally

d. . Hemolysis, particularly if they have G6PD deficiency

e. . Loss of visual acuity and red-green color blindness

28 / 65

28) What is the Mechanism of action of Dapsone against Mycobacterium leprae?

a. . Inhibition of dihydropteroate synthase

b. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. . Inhibits RNA synthesis.

d. . Inhibits mycobacterial arabinosyltransferases.

e. . Inhibition of neutrophil and eosinophil myeloperoxidase

29 / 65

29) A patient taking Anti-tuberculosis treatment, then he has a symptom as “peripheral neuropathy. Which one of the following medicines can cause this adverse reaction? Choose one best answer.

a. Rifampicin

b. Pyrizinamide

c. Ethambutol

d. Isoniazid

e. Streptomycin

30 / 65

30) Which of the following drugs, inhibits mycobacterial arabinosyl transferases? Choose one best answer.

a. Streptomycin

b. Isoniazid

c. Rifampin

d. Pyrizinamide

e. Ethambutol

31 / 65

31) Which statement is true about pharmacokinetic of Dapsone? Choose one best answer.

a. It is slowly released from the deposits.

b. Major portion of the drug is excreted in feces.

c. Absorption from the gut is variable.

d. Skin heavily infected with M leprae may contain more drug

e. Half-life may be 2 months.

32 / 65

32) A patient taking Anti-leprosy treatment, then he has symptoms as “Ichthyosis and dryness”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Dapsone

c. . Clofazimine

d. . Clarithromycin

e. . Minocycline

33 / 65

33) What is the Mechanism of Action of INH against M tuberculosis?

a. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

b. . Inhibits synthesis of mycolic acids.

c. . Inhibits mycobacterial arabinosyltransferases.

d. . Inhibits RNA synthesis.

e. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

34 / 65

34) A patient taking Anti-tuberculosis treatment, then he has an symptoms as “peripheral neuropathy. Which one of the following medicines can cause this adverse reaction?

a. . Streptomycin

b. . Ethambutol

c. . Isoniazid

d. . Pyrizinamide

e. . Rifampicin

35 / 65

35) The primary reason for the use of drug combinations in the treatment of tuberculosis is to

a. Provide prophylaxis against other bacterial infections.

b. Delay or prevent the emergence of resistance.

c. Reduce the incidence of adverse effects.

d. Enhance activity against metabolically inactive mycobacteria.

e. Ensure patient compliance with the drug regimen.

36 / 65

36) A patient taking Anti-tuberculosis treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction? Choose one best answer.

a. Isoniazid

b. Ethambutol

c. Rifampicin

d. Pyrizinamide

e. Streptomycin

37 / 65

37) Which statement is true about pharmacokinetic of Clofazimine?

a. . Cross the blood-brain barrier

b. . Half-life is variable, with values as long as 70 days.

c. . Excreted in the feces, small amount in the urine

d. . Excreted in urine

e. . Skin heavily infected with M leprae may contain more drug

38 / 65

38) What is the most common adverse reactions of Rifampicin? Choose one best answer.

a. Lupus-like syndrome, pellagra, arthralgia

b. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

c. Harmless orange color to urine, sweats, tears, and contact lenses.

d. Ototoxic and Nephrotoxic.

e. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

39 / 65

39) Which statement is true about pharmacokinetic of Dapsone?

a. . Skin heavily infected with M leprae may contain more drug

b. . Major portion of the drug is excreted in feces.

c. . Half-life may be 2 months.

d. . Absorption from the gut is variable.

e. . It is slowly released from the deposits.

40 / 65

40) A patient taking Anti-leprosy treatment, then he has symptoms as “Flu-like syndrome and thrombocytopenia”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Clofazimine

c. . Dapsone

d. . Minocycline

e. . Clarithromycin

41 / 65

41) Isoniazid may cause peripheral neuropathy and anaemia as its side effects because

a. . It prevents absorption of iron and ascorbic acid.

b. . It is toxic to nerves and to red blood cells.

c. . It interferes with pyridoxine metabolism and induces its deficiency.

d. . It is a type of hypersensitivity reaction.

42 / 65

42) What is the Mechanism of action EMB against TB?

a. . Inhibits RNA synthesis.

b. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

c. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

d. . Inhibits synthesis of mycolic acids.

e. . Inhibits mycobacterial arabinosyltransferases.

43 / 65

43) What is the most common adverse reactions of Pyrazinamide? Choose one best answer.

a. Hyperuricemia may provoke acute gouty arthritis.

b. Ototoxic and Nephrotoxic.

c. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. Harmless orange color to urine, sweats, tears, and contact lenses.

e. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

44 / 65

44) Which statement is the mechanism of actionof Clofazimine?

a. . Inhibition of RNA synthesis.

b. . Inhibition of dihydropteroate synthase

c. . Inhibition of mycobacterial growth and binds preferentially to mycobacterial DNA

d. . Inhibition of neutrophil and eosinophil myeloperoxidase

e. . Inhibition of mycobacterial arabinosyltransferases

45 / 65

45) A patient taking Anti-tuberculosis treatment, then he has symptoms as “arthralgia with biological sign of Hyperuricemia”. Which one of the following medicine can cause this adverse reaction? Choose one best answer.

a. Streptomycin

b. Ethambutol

c. Rifampicin

d. Pyrizinamide

e. Isoniazid

46 / 65

46) A patient taking Anti-tuberculosis treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction?

a. . Ethambutol

b. . Isoniazid

c. . Pyrizinamide

d. . Streptomycin

e. . Rifampicin

47 / 65

47) What is the most common adverse reactions of EMB ?

a. . Harmless orange color to urine, sweats, tears, and contact lenses.

b. . Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

c. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. . Ototoxic and Nephrotoxic.

e. . Acute gouty arthritis.

48 / 65

48) Which of the following drugs may cause “risk of postnatal haemorrhage”?

a. . Clarithromycin

b. . Minocycline

c. . Rifampicin

d. . Dapsone

e. . Clofazimine

49 / 65

49) A patient taking Anti-leprosy treatment, then he come back because his skin is dusty, his tongue and lips are blue. He has headache and also tired because of you. His SaO2 is low. Which is the following drugs my cause this side effects?

a. . Minocycline

b. . Clarithromycin

c. . Dapsone

d. . Clofazimine

e. . Rifampicin

50 / 65

50) A young female patient using an oral contraceptive is to be treated for pulmonary tuberculosis. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes

a. Pyrazinamide

b. Rifampicin

c. Streptomycin

d. Ethambutol

e. Isoniazid

51 / 65

51) A patient taking Anti-tuberculosis treatment, then he has symptoms as “arthralgia with biological sign of Hyperuricemia”. Which one of the following medicine can cause this adverse reaction?

a. . Isoniazid

b. . Pyrizinamide

c. . Ethambutol

d. . Rifampicin

e. . Streptomycin

52 / 65

52) What is the most common toxicity of Streptomycin? Choose one best answer.

a. Ototoxic and Nephrotoxic.

b. Rashes, thrombocytopenia, and nephritis.

c. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. Immunologic Reactions, Hepatitis and Peripheral neuropathy.

e. Hyperuricemia may provoke acute gouty arthritis.

53 / 65

53) Pyridoxine is given to a patient of tuberculosis prevents

a. Ethambutol induced visual defects

b. Rifampicin induced hepatotoxicity

c. Streptomycin induced nephrotoxicity

d. INH induced peripheral neuritis

e. Pyrazinamide induced neurotoxicity

54 / 65

54) A patient taking Anti-leprosy treatment, then he come back with his lawyer because his skin is dusty, his tongue and lips are blue…and he threatens to sue….He has headache and also tired because of you. His SaO 2 is low. Which one of the following drugs can cause this adverse reaction?

a. Thalidomide

b. Steroid

c. Dapsone

d. Rifampcin

e. Clofazimine

55 / 65

55) A young female patient using an oral contraceptive is to be treated for leprosy. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes:

a. . Rifampicin

b. . Ofloxacin

c. . Minocycline

d. . Dapsone

e. . Clofazimine

56 / 65

56) Which statement is “correct” about adverse reactions of Dapsone? Choose one best answer.

a. Gastrointestinal intolerance occurs occasionally.

b. Skin discoloration ranging from red-brown to nearly black.

c. It may cause cholestatic jaundiceand occasionally hepatitis

d. Methemoglobinemia is common.

e. Loss of visual acuity and red-green color blindness.

57 / 65

57) A patient taking Anti-leprosy treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction?

a. . Minocycline

b. . Dapsone

c. . Clofazimine

d. . Rifampicin

e. . Ofloxacin

58 / 65

58) Pyridoxine is given to a patient of tuberculosis prevents

a. . INH induced peripheral neuritis

b. . Ethambutol induced visual defects

c. . Rifampicin induced hepatotoxicity

d. . Pyrazinamide induced neurotoxicity

e. . Streptomycin induced nephrotoxicity

59 / 65

59) Which statement is true about pharmacokinetic of Clofazimine?

a. . Cross the blood-brain barrier

b. . Cross the placenta, and is found in human breast milk

c. . Half-life may be 2 months

d. . Skin heavily infected with M leprae may contain several times more drug than normal skin

e. . Metabolism: not known

60 / 65

60) What is the most common adverse reactions of INH?

a. . Flu-like syndrome and thrombocytopenia

b. . Ototoxic and Nephrotoxic.

c. . Harmless orange color to urine, sweats, tears, and contact lenses.

d. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

e. . The risk of peripheral neuropathy

61 / 65

61) What is the most common adverse reactions of Ethambutol? Choose one best answer.

a. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

b. Harmless orange color to urine, sweats, tears, and contact lenses.

c. Acute gouty arthritis.

d. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

e. Ototoxic and Nephrotoxic.

62 / 65

62) WHO regime for paucibacillary leprosy (PB) in adult is:

a. . 300mg Clofazimine daily + 300mg Rifampcin daily

b. . 100mg Dapsone + 600mg Rifampcin + 300mg Clofazimine daily

c. . 50mg Dapsone daily + 450mg Rifampicn monthly

d. . 100mg Dapsone daily + 600mg Rifampicin monthly

e. . 100mg Dapsone daily + 600mg Rifampicn daily

63 / 65

63) Which statement is true about Pharmacokinetics of Pyrazinamide? Choose one best answer.

a. Half-life: 8-11h, metabolized by the liver, excreted in the urine.

b. Half-life: 3-5 h, metabolized by the liver, about 20% is excreted unchanged in the feces.

c. Half-life: 8-11h, not metabolized in the body and eliminate with active form.

d. Half-life: 3-4 h, metabolized by the liver, about 20% is excreted unchanged in the feces.

64 / 65

64) What is the common adverse reactions of Dapsone?

a. . Ototoxic and Nephrotoxic

b. . Methemoglobinemia

c. . Harmless orange color to urine, sweats, tears, and contact lenses

d. . Hyperuricemia may provoke acute gouty arthritis

e. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness

65 / 65

65) A patient taking Anti-leprosy treatment, then he has symptoms as “Blurred vision, paraesthesia”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Clarithromycin

c. . Minocycline

d. . Dapsone

e. . Clofazimine

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