Pharmacologie Preparation (Pr. BC Youttiroung)

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1 / 65

1) What is the Mechanism of action EMB against TB?

a. . Inhibits mycobacterial arabinosyltransferases.

b. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

c. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

d. . Inhibits synthesis of mycolic acids.

e. . Inhibits RNA synthesis.

2 / 65

2) A patient taking Anti-leprosy treatment, then he has “Erythema nodosum leprosum”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Minocycline

c. . Dapsone

d. . Clofazimine

e. . Clarithromycin

3 / 65

3) A patient taking Anti-tuberculosis treatment, then he has symptoms as “arthralgia with biological sign of Hyperuricemia”. Which one of the following medicine can cause this adverse reaction?

a. . Ethambutol

b. . Rifampicin

c. . Isoniazid

d. . Pyrizinamide

e. . Streptomycin

4 / 65

4) Which statement is “correct” about adverse reactions of Dapsone? Choose one best answer.

a. Methemoglobinemia is common.

b. It may cause cholestatic jaundiceand occasionally hepatitis

c. Loss of visual acuity and red-green color blindness.

d. Skin discoloration ranging from red-brown to nearly black.

e. Gastrointestinal intolerance occurs occasionally.

5 / 65

5) A young female patient using an oral contraceptive is to be treated for pulmonary tuberculosis. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes:

a. . Ethambutol

b. . Pyrazinamide

c. . Isoniazid

d. . Rifampicin

e. . Streptomycin

6 / 65

6) Skin pigmentation and icthyosis like side effects are seen in patient who received:

a. . Dapsone

b. . Clofazimine

c. . Rifampcin

d. . Thalidomide

e. . Steroid

7 / 65

7) What is the Mechanism of Action of Isoniazid against M tuberculosis? Choose one best answer.

a. Inhibits mycobacterial arabinosyltransferases.

b. Inhibits RNA synthesis.

c. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

d. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

e. Inhibits synthesis of mycolic acids.

8 / 65

8) Dose of rifampicin recommended in multibacillary leprosy in adult is 600 mg

a. Twice weekly

b. Once in a month

c. Once daily

d. Twice monthly

e. Once in a week

9 / 65

9) What is the Mechanism of action of Dapsone against Mycobacterium leprae?

a. . Inhibition of neutrophil and eosinophil myeloperoxidase

b. . Inhibits mycobacterial arabinosyltransferases.

c. . Inhibition of dihydropteroate synthase

d. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

e. . Inhibits RNA synthesis.

10 / 65

10) What is the most common adverse reactions of EMB ?

a. . Acute gouty arthritis.

b. . Ototoxic and Nephrotoxic.

c. . Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

d. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

e. . Harmless orange color to urine, sweats, tears, and contact lenses.

11 / 65

11) What is the Mechanism of action Ethambutol against TB? Choose one best answer.

a. Inhibits mycobacterial arabinosyltransferases.

b. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

c. Inhibits RNA synthesis.

d. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

e. Inhibits synthesis of mycolic acids.

12 / 65

12) What is the most common adverse reactions of PZA ?

a. . Harmless orange color to urine, sweats, tears, and contact lenses.

b. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. . Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

d. . Ototoxic and Nephrotoxic.

e. . Hyperuricemia may provoke acute gouty arthritis.

13 / 65

13) Which statement is the adverse reaction of Clofazimine?

a. . Ichthyosis and dryness

b. . Erythema nodosumleprosum

c. . Methemoglobinemia is common, but usually is not a problem clinically

d. . Gastrointestinal intolerance, fever, pruritus.

e. . Hemolysis, particularly if they have G6PD deficiency

14 / 65

14) Dose of Rifampicin recommended in multibacillary leprosy in adult is 600 mg

a. . Once daily

b. . Once in a month

c. . Once in a week

d. . Twice monthly

e. . Twice weekly

15 / 65

15) What is the most common adverse reactions of Isoniazid? Choose one best answer.

a. Harmless orange color to urine, sweats, tears, and contact lenses.

b. Flu-like syndrome and thrombocytopenia

c. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. The risk of peripheral neuropathy

e. Ototoxic and Nephrotoxic.

16 / 65

16) 4. What is the Mechanism of action Rifampicin against TB?

a. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

b. . Inhibits synthesis of mycolic acids.

c. . Inhibits mycobacterial arabinosyltransferases.

d. . Inhibits RNA synthesis.

e. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

17 / 65

17) The primary reason for the use of drug combinations in the treatment of tuberculosis is to

a. Ensure patient compliance with the drug regimen.

b. Provide prophylaxis against other bacterial infections.

c. Enhance activity against metabolically inactive mycobacteria.

d. Reduce the incidence of adverse effects.

e. Delay or prevent the emergence of resistance.

18 / 65

18) A patient taking Anti-leprosy treatment, then he has symptoms as “Blurred vision, paraesthesia”. Which one of the following medicine can cause this adverse reaction?

a. . Dapsone

b. . Minocycline

c. . Clofazimine

d. . Rifampicin

e. . Clarithromycin

19 / 65

19) A patient taking Anti-tuberculosis treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction? Choose one best answer.

a. Ethambutol

b. Streptomycin

c. Pyrizinamide

d. Rifampicin

e. Isoniazid

20 / 65

20) A patient taking Anti-tuberculosis treatment, then he has a symptom as “peripheral neuropathy. Which one of the following medicines can cause this adverse reaction? Choose one best answer.

a. Isoniazid

b. Streptomycin

c. Rifampicin

d. Ethambutol

e. Pyrizinamide

21 / 65

21) What is the most common toxicity of Streptomycin? Choose one best answer.

a. Ototoxic and Nephrotoxic.

b. Hyperuricemia may provoke acute gouty arthritis.

c. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

d. Rashes, thrombocytopenia, and nephritis.

e. Immunologic Reactions, Hepatitis and Peripheral neuropathy.

22 / 65

22) What is the common adverse reactions of Dapsone?

a. . Methemoglobinemia

b. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness

c. . Ototoxic and Nephrotoxic

d. . Harmless orange color to urine, sweats, tears, and contact lenses

e. . Hyperuricemia may provoke acute gouty arthritis

23 / 65

23) WHO regime for paucibacillary leprosy (PB) in adult is:

a. 100mg Dapsone daily + 600mg Rifampicn daily

b. 50mg Dapsone daily + 450mg Rifampicn monthly

c. 100mg Dapsone daily + 600mg Rifampicin monthly

d. 300mg Clofazimine daily + 300mg Rifampcin daily

e. 100mg Dapsone + 600mg Rifampcin + 300mg Clofazimine daily

24 / 65

24) What is the most common adverse reactions of Ethambutol? Choose one best answer.

a. Harmless orange color to urine, sweats, tears, and contact lenses.

b. Ototoxic and Nephrotoxic.

c. Acute gouty arthritis.

d. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

e. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

25 / 65

25) A patient taking Anti-tuberculosis treatment, then he has an symptoms as “peripheral neuropathy. Which one of the following medicines can cause this adverse reaction?

a. . Ethambutol

b. . Isoniazid

c. . Streptomycin

d. . Pyrizinamide

e. . Rifampicin

26 / 65

26) Isoniazid may cause peripheral neuropathy and anaemia as its side effects because

a. . It interferes with pyridoxine metabolism and induces its deficiency.

b. . It is toxic to nerves and to red blood cells.

c. . It is a type of hypersensitivity reaction.

d. . It prevents absorption of iron and ascorbic acid.

27 / 65

27) Which of the following drugs may cause “risk of postnatal haemorrhage”?

a. . Minocycline

b. . Clofazimine

c. . Rifampicin

d. . Dapsone

e. . Clarithromycin

28 / 65

28) Which statement is the adverse reaction of Clofazimine? Choose one best answer.

a. Skin discoloration ranging from pink to brownish-black.

b. Hemolysis, particularly if they have G6PD deficiency.

c. Erythema nodosumleprosum often develops.

d. Methemoglobinemia is common, but usually is not a problem clinically.

e. Gastrointestinal intolerance, fever, pruritus.

29 / 65

29) Pyridoxine is given to a patient of tuberculosis prevents

a. Ethambutol induced visual defects

b. Rifampicin induced hepatotoxicity

c. Pyrazinamide induced neurotoxicity

d. INH induced peripheral neuritis

e. Streptomycin induced nephrotoxicity

30 / 65

30) A patient taking Anti-leprosy treatment, then he come back with his lawyer because his skin is dusty, his tongue and lips are blue…and he threatens to sue….He has headache and also tired because of you. His SaO 2 is low. Which one of the following drugs can cause this adverse reaction?

a. Steroid

b. Thalidomide

c. Clofazimine

d. Rifampcin

e. Dapsone

31 / 65

31) What is the common adverse reactions of Rifampicin?

a. . Hemolysis, particularly if they have G6PD deficiency

b. . Erythema nodosumleprosum

c. . Skin discoloration ranging from red-brown to nearly black

d. . Hyperuricemia may provoke acute gouty arthritis

e. . Flu-like syndrome and thrombocytopenia

32 / 65

32) A patient taking Anti-tuberculosis treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction?

a. . Streptomycin

b. . Isoniazid

c. . Rifampicin

d. . Pyrizinamide

e. . Ethambutol

33 / 65

33) Which statement is the adverse reaction of Clofazimine?

a. . Erythema nodosumleprosum

b. . Hemolysis, particularly if they have G6PD deficiency

c. . Methemoglobinemia is common, but usually is not a problem clinically

d. . Gastrointestinal intolerance, fever, pruritus.

e. . Skin discoloration ranging from pink to brownish-black

34 / 65

34) Which statement is true about pharmacokinetic of Rifampicin?

a. . Major portion of the drug is excreted in feces.

b. . It is slowly released from the deposits.

c. . Skin heavily infected with M leprae may contain more drug

d. . Excreted in the feces, small amount in the urine

e. . Half-life may be 2 months.

35 / 65

35) Isoniazid may cause peripheral neuropathy and anaemia as its side effects because

a. It interferes with pyridoxine metabolism and induces its deficiency.

b. It prevents absorption of iron and ascorbic acid.

c. It is toxic to nerves and to red blood cells.

d. It is a type of hypersensitivity reaction.

36 / 65

36) What is the most common adverse reactions of Rifampicin?

a. . Gastrointestinal intolerance occurs occasionally

b. . Hemolysis, particularly if they have G6PD deficiency

c. . Harmless orange color to urine, sweats, tears, and contact lenses

d. . Loss of visual acuity and red-green color blindness

e. . Methemoglobinemia is common

37 / 65

37) A patient taking Anti-leprosy treatment, then he has “hemolytic anemia”. Which one of the following medicine can cause this adverse reaction?

a. . Clarithromycin

b. . Clofazimine

c. . Rifampicin

d. . Dapsone

e. . Minocycline

38 / 65

38) A young female patient using an oral contraceptive is to be treated for leprosy. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes:

a. . Rifampicin

b. . Dapsone

c. . Clofazimine

d. . Ofloxacin

e. . Minocycline

39 / 65

39) What is the recommended standard treatment duration for leprosy?

a. . 1 or 2 months depending on the operational or clinical classification of the disease

b. . 12 or 18 months depending on the operational or clinical classification of the disease

c. . 6 or 12 months depending on the operational or clinical classification of the disease

d. . 6 months for children and 12 months for adults

e. . 6 or 8 months depending on the operational or clinical classification of the disease

40 / 65

40) Which statement is true about pharmacokinetic of Clofazimine?

a. . Skin heavily infected with M leprae may contain several times more drug than normal skin

b. . Cross the placenta, and is found in human breast milk

c. . Cross the blood-brain barrier

d. . Metabolism: not known

e. . Half-life may be 2 months

41 / 65

41) A patient taking Anti-leprosy treatment, then he has symptoms as “Ichthyosis and dryness”. Which one of the following medicine can cause this adverse reaction?

a. . Clarithromycin

b. . Dapsone

c. . Rifampicin

d. . Clofazimine

e. . Minocycline

42 / 65

42) Which of the following drugs, inhibits mycobacterial arabinosyl transferases?

a. . Pyrizinamide

b. . Streptomycin

c. . Ethambutol

d. . Rifampin

e. . Isoniazid

43 / 65

43) Which statement is true about pharmacokinetic of Dapsone?

a. . Skin heavily infected with M leprae may contain more drug

b. . It is slowly released from the deposits.

c. . Half-life may be 2 months.

d. . Absorption from the gut is variable.

e. . Major portion of the drug is excreted in feces.

44 / 65

44) What is the most common adverse reactions of INH?

a. . Flu-like syndrome and thrombocytopenia

b. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. . The risk of peripheral neuropathy

d. . Harmless orange color to urine, sweats, tears, and contact lenses.

e. . Ototoxic and Nephrotoxic.

45 / 65

45) A young female patient using an oral contraceptive is to be treated for pulmonary tuberculosis. She is advised to use an additional method of contraception since the efficacy of the oral agents is commonly decreased if her drug regimen includes

a. Ethambutol

b. Streptomycin

c. Rifampicin

d. Isoniazid

e. Pyrazinamide

46 / 65

46) What is the Mechanism of Action of INH against M tuberculosis?

a. . Inhibits synthesis of mycolic acids.

b. . Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

c. . Inhibits mycobacterial arabinosyltransferases.

d. . Inhibits RNA synthesis.

e. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

47 / 65

47) A patient taking Anti-leprosy treatment, then he come back because his skin is dusty, his tongue and lips are blue. He has headache and also tired because of you. His SaO2 is low. Which is the following drugs my cause this side effects?

a. . Clofazimine

b. . Minocycline

c. . Clarithromycin

d. . Dapsone

e. . Rifampicin

48 / 65

48) Which statement is true about Pharmacokinetics of Pyrazinamide? Choose one best answer.

a. Half-life: 3-4 h, metabolized by the liver, about 20% is excreted unchanged in the feces.

b. Half-life: 8-11h, metabolized by the liver, excreted in the urine.

c. Half-life: 3-5 h, metabolized by the liver, about 20% is excreted unchanged in the feces.

d. Half-life: 8-11h, not metabolized in the body and eliminate with active form.

49 / 65

49) A patient taking Anti-leprosy treatment, then he has symptoms as “orange colors to urine, sweat, tears, and contact lenses”. Which one of the following medicine can cause this adverse reaction?

a. . Rifampicin

b. . Ofloxacin

c. . Minocycline

d. . Clofazimine

e. . Dapsone

50 / 65

50) A patient taking Anti-leprosy treatment, then he has symptoms as “Flu-like syndrome and thrombocytopenia”. Which one of the following medicine can cause this adverse reaction?

a. . Clofazimine

b. . Clarithromycin

c. . Rifampicin

d. . Minocycline

e. . Dapsone

51 / 65

51) What is the Mechanism of action of Rifampicin against Mycobacterium leprae?

a. . Inhibits bacterial DNA-dependent RNA synthesis

b. . Inhibition of neutrophil and eosinophil myeloperoxidase

c. . Inhibition of dihydropteroate synthase

d. . Inhibits mycobacterial arabinosyltransferases

e. . Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

52 / 65

52) What is the most common toxicity of streptomycin?

a. . Ototoxic and Nephrotoxic.

b. . Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

c. . Rashes, thrombocytopenia, and nephritis.

d. . Immunologic Reactions, Hepatitis and Peripheral neuropathy.

e. . Hyperuricemia may provoke acute gouty arthritis.

53 / 65

53) Which statement is true about pharmacokinetic of Dapsone? Choose one best answer.

a. It is slowly released from the deposits.

b. Half-life may be 2 months.

c. Major portion of the drug is excreted in feces.

d. Skin heavily infected with M leprae may contain more drug

e. Absorption from the gut is variable.

54 / 65

54) Pyridoxine is given to a patient of tuberculosis prevents

a. . Ethambutol induced visual defects

b. . Rifampicin induced hepatotoxicity

c. . Streptomycin induced nephrotoxicity

d. . INH induced peripheral neuritis

e. . Pyrazinamide induced neurotoxicity

55 / 65

55) A patient taking Anti-tuberculosis treatment, then he has symptoms as “arthralgia with biological sign of Hyperuricemia”. Which one of the following medicine can cause this adverse reaction? Choose one best answer.

a. Streptomycin

b. Isoniazid

c. Ethambutol

d. Pyrizinamide

e. Rifampicin

56 / 65

56) The primary reason for the use of drug combinations in the treatment of tuberculosis is to:

a. . Reduce the incidence of adverse effects.

b. . Delay or prevent the emergence of resistance.

c. . Enhance activity against metabolically inactive mycobacteria.

d. . Ensure patient compliance with the drug regimen.

e. . Provide prophylaxis against other bacterial infections.

57 / 65

57) What is the Mechanism of action Rifampicin against TB? Choose one best answer.

a. Converted to the active pyrazinoic acid under acidic conditions of macrophage lysosomes.

b. Inhibits mycobacterial arabinosyltransferases.

c. Prevents bacterial protein synthesis by binding to the S12 ribosomal subunit.

d. Inhibits synthesis of mycolic acids.

e. Inhibits RNA synthesis.

58 / 65

58) What is the recommended standard treatment duration for leprosy?

a. 6 months for children and 12 months for adults

b. 12 or 18 months depending on the operational or clinical classification of the disease

c. 6 or 8 months depending on the operational or clinical classification of the disease

d. 6 or 12 months depending on the operational or clinical classification of the disease

e. 1 or 2 months depending on the operational or clinical classification of the disease

59 / 65

59) Which statement is true about pharmacokinetic of Dapsone?

a. . Excretion into bile and urine

b. . It is slowly released from the deposits.

c. . Cross the placenta, and is found in human breast milk

d. . Half-life may be 2 months.

e. . Major portion of the drug is excreted in feces.

60 / 65

60) Which of the following drugs, inhibits mycobacterial arabinosyl transferases? Choose one best answer.

a. Isoniazid

b. Streptomycin

c. Pyrizinamide

d. Rifampin

e. Ethambutol

61 / 65

61) Which statement is the mechanism of actionof Clofazimine?

a. . Inhibition of mycobacterial arabinosyltransferases

b. . Inhibition of neutrophil and eosinophil myeloperoxidase

c. . Inhibition of RNA synthesis.

d. . Inhibition of dihydropteroate synthase

e. . Inhibition of mycobacterial growth and binds preferentially to mycobacterial DNA

62 / 65

62) Which statement is true about pharmacokinetic of Clofazimine?

a. . Excreted in the feces, small amount in the urine

b. . Half-life is variable, with values as long as 70 days.

c. . Cross the blood-brain barrier

d. . Excreted in urine

e. . Skin heavily infected with M leprae may contain more drug

63 / 65

63) What is the most common adverse reactions of Pyrazinamide? Choose one best answer.

a. Ototoxic and Nephrotoxic.

b. Harmless orange color to urine, sweats, tears, and contact lenses.

c. Hyperuricemia may provoke acute gouty arthritis.

d. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

e. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

64 / 65

64) What is the most common adverse reactions of Rifampicin? Choose one best answer.

a. Lupus-like syndrome, pellagra, arthralgia

b. Ototoxic and Nephrotoxic.

c. Harmless orange color to urine, sweats, tears, and contact lenses.

d. Peripheral neuropathy and CNS toxicity: memory loss, psychosis, and seizures.

e. Retrobulbar neuritis, resulting in loss of visual acuity and red-green color blindness.

65 / 65

65) WHO regime for paucibacillary leprosy (PB) in adult is:

a. . 100mg Dapsone daily + 600mg Rifampicn daily

b. . 100mg Dapsone + 600mg Rifampcin + 300mg Clofazimine daily

c. . 100mg Dapsone daily + 600mg Rifampicin monthly

d. . 50mg Dapsone daily + 450mg Rifampicn monthly

e. . 300mg Clofazimine daily + 300mg Rifampcin daily

Your score is

The average score is 95%

Any comments?

Any problems/errors or mistakes found while testing, please let us know for modification!

និស្សិតអាចប្រាប់មកកាន់ពួកយើងបានដើម្បីកែកំហុស ឬអំពីបញ្ហាដោយអចេតនាណាមួយដែលកើតមានកំឡុងពេលធ្វើតេស្ត