A 40 years old lady, house wife, lives in Phnom Penh, comes to Psychiatric OPD with her complaint of difficulty in breathing, cold extremities, difficulty falling asleep and look a bit pale. Her symptoms happened for more than 2 years. Her BP: 125/80mnhg, Pulse: 98/mn, T: 36.5 oC. If the patient answer with the therapist question with palpitation, sweating, trembling and psychological distress most of every day. Which is the main following diagnosis could be made?